How mothers tolerate their children
成果类型：
Editorial Material
署名作者：
Porrett, Paige M.
署名单位：
University of Alabama System; University of Alabama Birmingham
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-12507
DOI：
10.1126/science.adk1218
发表日期：
2023-09-22
页码：
1286-1286
关键词：
摘要：
When pregnant, maternal immunologic tolerance is required to ensure that the fetus is not rejected by the mother's immune system. This tolerance is achieved by expansion of a subset of CD4(+) T cells with regulatory properties (T-reg cells) that protect against fetal loss (1-3). Maternal T-reg cells develop immunologic memory, which confers fetal-specific protection against complications in subsequent pregnancy (4). Prior studies have suggested that memory T-reg cells are sustained by fetal microchimerism, the presence of fetal antigens that persist in the mother after birth. But the details of how T-reg cells interact with fetal antigens after pregnancy have remained a mystery (5). On page 1324 of this issue, Shao et al. (6) used a mouse model to demonstrate that these small pools of fetal antigen change between pregnancies and affect the fate of fetal-specific T-reg cells in the maternal repertoire. Therefore, the study reveals how mothers remember their genetically distinct children through changes in both the pool of antigen and the pool of memory T-reg cells.