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作者：Song, Jiarui; Gooding, Anne R.; Hemphill, Wayne O.; Love, Brittney D.; Robertson, Anne; Yao, Liqi; Zon, Leonard I.; North, Trista E.; Kasinath, Vignesh; Cech, Thomas R.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Howard Hughes Medical Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard Medical School
摘要：Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for G-quadruplex RNA. In this work, we present a 3.3-angstrom-resolution cryo-electron microscopy structure of PRC2 bound to a G-quadruplex RNA. Notably, RNA mediates the dimerization of PRC2 by binding both protomers and inducing a protein interface composed of two copies of t...
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作者：[Anonymous]
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作者：Boller, Kimberly
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作者：Brainard, Jeffrey
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作者：Prieto-Curiel, Rafael; Campedelli, Gian Maria; Hope, Alejandro
作者单位：University of Trento
摘要：Mexican cartels lose many members as a result of conflict with other cartels and incarcerations. Yet, despite their losses, cartels manage to increase violence for years. We address this puzzle by leveraging data on homicides, missing persons, and incarcerations in Mexico for the past decade along with information on cartel interactions. We model recruitment, state incapacitation, conflict, and saturation as sources of cartel size variation. Results show that by 2022, cartels counted 160,000 t...
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作者：Shao, Tzu-Yu; Kinder, Jeremy M.; Harper, Gavin; Pham, Giang; Peng, Yanyan; Liu, James; Gregory, Emily J.; Sherman, Bryan E.; Wu, Yuehong; Iten, Alexandra E.; Hu, Yueh-Chiang; Russi, Abigail E.; Erickson, John J.; Miller-Handley, Hilary; Way, Sing Sing
作者单位：University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati
摘要：Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. We show that preexisting FMcs become displaced by new FMcs during pregnancy and that FMc tonic stimulation is essential for expansion of protective fetal-specific forkhead box P3 (FOXP3)-positive regulatory T cells (T-reg cells). Maternal microchimeric cells and accumulation of T-reg cells with noninherited maternal ...
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作者：Chen, Guining; Chen, Cailing; Guo, Yanan; Chu, Zhenyu; Pan, Yang; Liu, Guozhen; Liu, Gongping; Han, Yu; Jin, Wanqin; Xu, Nanping
作者单位：Nanjing Tech University; King Abdullah University of Science & Technology; Suzhou Laboratory
摘要：Mixed-matrix membranes (MMMs) that combine processable polymer with more permeable and selective filler have potential for molecular separation, but it remains difficult to control their interfacial compatibility and achieve ultrathin selective layers during processing, particularly at high filler loading. We present a solid-solvent processing strategy to fabricate an ultrathin MMM (thickness less than 100 nanometers) with filler loading up to 80 volume %. We used polymer as a solid solvent to...
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作者：Shapiro, Adam R.
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作者：Wong, Gifford J.
作者单位：Science & Technology Policy Institute
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作者：Mangalhara, Kailash Chandra; Varanasi, Siva Karthik; Johnson, Melissa A.; Burns, Mannix J.; Rojas, Gladys R.; Esparza Molto, Pau B.; Sainz, Alva G.; Tadepalle, Nimesha; Abbott, Keene L.; Mendiratta, Gaurav; Chen, Dan; Farsakoglu, Yagmur; Kunchok, Tenzin; Hoffmann, Filipe Araujo; Parisi, Bianca; Rincon, Mercedes; Vander Heiden, Matthew G.; Bosenberg, Marcus; Hargreaves, Diana C.; Kaech, Susan M.; Shadel, Gerald S.
作者单位：Salk Institute; Yale University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Whitehead Institute; Children's Hospital Colorado; University of Colorado System; University of Colorado Anschutz Medical Campus; Yale University; Yale University; Yale University
摘要：Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow, remains unclear. In this work, we report that the loss of CII, but not that of CI, reduces melanoma tumor growth by increasing antigen presentation and T cell-mediated killing. This is driven by succinate-mediated transcriptional and epigenetic activation of major histocompatibility complex-antigen proce...
