Metabolic control of antitumor immunity

• 成果类型: Editorial Material
• 署名作者: Pouikli, Andromachi; Frezza, Christian
• 署名单位: University of Cologne; University of Cologne
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12508
• DOI: 10.1126/science.adk1785
• 发表日期: 2023-09-22
• 页码: 1287-1288
• 关键词: mitochondria

摘要

The metabolism of cancer cells adapts to meet an increased need for the energy, biosynthesis, and antioxidants required for proliferation, tumor growth, and metastasis (1). Yet, whether this metabolic reprogramming affects the recognition and elimination of cancer cells by immune cells has not been well investigated. On page 1316 of this issue, Mangalhara et al. (2) report a connection between a cancer cell's mitochondrial metabolism and its ability to evoke an immune response in a mouse model of melanoma. Specific perturbations of the mitochondrial electron transport chain increased succinate production in cancer cells. Succinate accumulation caused epigenetic rearrangements, which induced the expression of genes involved in antigen presentation. This promoted the detection of tumor cells by surveilling T cells-tumor immunogenicity. The identification of a mechanism by which mitochondrial metabolites shape tumor immunogenicity has potential for developing anticancer therapies.