2023

最新文章

• Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly AI翻译
  作者：Rizalar, Filiz Sila; Lucht, Max T.; Petzoldt, Astrid; Kong, Shuhan; Sun, Jiachen; Vines, James H.; Telugu, Narasimha Swamy; Diecke, Sebastian; Kaas, Thomas; Bullmann, Torsten; Schmied, Christopher; Loewe, Delia; King, Jason S.; Cho, Wonhwa; Hallermann, Stefan; Puchkov, Dmytro; Sigrist, Stephan J.; Haucke, Volker
  作者单位：Free University of Berlin; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Sheffield; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Leipzig University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
  摘要：Neurons relay information via specialized presynaptic compartments for neurotransmission. Unlike conventional organelles, the specialized apparatus characterizing the neuronal presynapse must form de novo. How the components for presynaptic neurotransmission are transported and assembled is poorly understood. Our results show that the rare late endosomal signaling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P-2] directs the axonal cotransport of synaptic vesicle and active zone protein...
• Chiral molecules to transmit electron spin AI翻译
  作者：Subotnik, Joseph E.
  作者单位：University of Pennsylvania
• One million (paper) satellites AI翻译
  作者：Falle, Andrew; Wright, Ewan; Boley, Aaron; Byers, Michael
  作者单位：University of British Columbia; University of British Columbia; University of British Columbia
• Engineered bacteria guide T cells to tumors AI翻译
  作者：Bressler, Eric M.; Wong, Wilson W.
  作者单位：Boston University
• Single-cell analysis of prenatal and postnatal human cortical development AI翻译
  作者：Velmeshev, Dmitry; Perez, Yonatan; Yan, Zihan; Valencia, Jonathan E.; Castaneda-Castellanos, David R.; Wang, Li; Schirmer, Lucas; Mayer, Simone; Wick, Brittney; Wang, Shaohui; Nowakowski, Tomasz Jan; Paredes, Mercedes; Huang, Eric J.; Kriegstein, Arnold R.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Duke University; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Ruprecht Karls University Heidelberg; University of California System; University of California Santa Cruz; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：We analyzed >700,000 single-nucleus RNA sequencing profiles from 106 donors during prenatal and postnatal developmental stages and identified lineage-specific programs that underlie the development of specific subtypes of excitatory cortical neurons, interneurons, glial cell types, and brain vasculature. By leveraging single-nucleus chromatin accessibility data, we delineated enhancer gene regulatory networks and transcription factors that control commitment of specific cortical lineages. By i...
• In 'proof of concept,' CRISPR-edited chickens shrug off flu AI翻译
  作者：Cohen, Jon
  摘要：Edits to one gene can't completely stop infections, however
• Comparative transcriptomics reveals human-specific cortical features AI翻译
  作者：Jorstad, Nikolas L.; Song, Janet H. T.; Exposito-Alonso, David; Suresh, Hamsini; Castro-Pacheco, Nathan; Krienen, Fenna M.; Yanny, Anna Marie; Close, Jennie; Gelfand, Emily; Long, Brian; Seeman, Stephanie C.; Travaglini, Kyle J.; Basu, Soumyadeep; Beaudin, Marc; Bertagnolli, Darren; Crow, Megan; Ding, Song-Lin; Eggermont, Jeroen; Glandon, Alexandra; Goldy, Jeff; Kiick, Katelyn; Kroes, Thomas; Mcmillen, Delissa; Pham, Trangthanh; Rimorin, Christine; Siletti, Kimberly; Somasundaram, Saroja; Tieu, Michael; Torkelson, Amy; Feng, Guoping; Hopkins, William D.; Hollt, Thomas; Keene, C. Dirk; Linnarsson, Sten; Mccarroll, Steven A.; Lelieveldt, Boudewijn P.; Sherwood, Chet C.; Smith, Kimberly; Walsh, Christopher A.; Dobin, Alexander; Gillis, Jesse; Lein, Ed S.; Hodge, Rebecca D.; Bakken, Trygve E.
  作者单位：Allen Institute for Brain Science; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Cold Spring Harbor Laboratory; Harvard University; Harvard Medical School; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Delft University of Technology; Cold Spring Harbor Laboratory; Karolinska Institutet; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Texas System; UTMD Anderson Cancer Center; University of Washington; University of Washington Seattle; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Delft University of Technology; George Washington University; University of Toronto
  摘要：INTRODUCTION: The cerebral cortex is involved in complex cognitive functions such as language. Although the diversity and organization of cortical cell types has been extensively studied in several mammalian species, human cortical specializations that may underlie our distinctive cognitive abilities remain poorly understood.RATIONALE: Single-nucleus RNA sequencing (snRNA-seq) offers a relatively unbiased characterization of cellular diversity of brain regions. Comparative transcriptomic analy...
• Photocatalysis gets energized by abundant metals AI翻译
  作者：Yaltseva, Polina; Wenger, Oliver S.
  作者单位：University of Basel
• Direct observation of chirality-induced spin selectivity in electron donor-acceptor molecules AI翻译
  作者：Eckvahl, Hannah J.; Tcyrulnikov, Nikolai A.; Chiesa, Alessandro; Bradley, Jillian M.; Young, Ryan M.; Carretta, Stefano; Krzyaniak, Matthew D.; Wasielewski, Michael R.
  作者单位：Northwestern University; Northwestern University; University of Parma
  摘要：The role of chirality in determining the spin dynamics of photoinduced electron transfer in donor-acceptor molecules remains an open question. Although chirality-induced spin selectivity (CISS) has been demonstrated in molecules bound to substrates, experimental information about whether this process influences spin dynamics in the molecules themselves is lacking. Here we used time-resolved electron paramagnetic resonance spectroscopy to show that CISS strongly influences the spin dynamics of ...
• Transcriptomic cytoarchitecture reveals principles of human neocortex organization AI翻译
  作者：Jorstad, Nikolas L.; Close, Jennie; Johansen, Nelson; Yanny, Anna Marie; Barkan, Eliza R.; Travaglini, Kyle J.; Bertagnolli, Darren; Campos, Jazmin; Casper, Tamara; Crichton, Kirsten; Dee, Nick; Ding, Song-Lin; Gelfand, Emily; Goldy, Jeff; Hirschstein, Daniel; Kiick, Katelyn; Kroll, Matthew; Kunst, Michael; Lathia, Kanan; Long, Brian; Martin, Naomi; Mcmillen, Delissa; Pham, Trangthanh; Rimorin, Christine; Ruiz, Augustin; Shapovalova, Nadiya; Shehata, Soraya; Siletti, Kimberly; Somasundaram, Saroja; Sulc, Josef; Tieu, Michael; Torkelson, Amy; Tung, Herman; Callaway, Edward M.; Hof, Patrick R.; Keene, C. Dirk; Levi, Boaz P.; Linnarsson, Sten; Mitra, Partha P.; Smith, Kimberly; Hodge, Rebecca D.; Bakken, Trygve E.; Lein, Ed S.
  作者单位：Allen Institute for Brain Science; Karolinska Institutet; Salk Institute; Icahn School of Medicine at Mount Sinai; University of Washington; University of Washington Seattle; Cold Spring Harbor Laboratory
  摘要：INTRODUCTION The human neocortex is generally organized into six layers of neurons but the size and cellular composition of these layers varies across the cortex, and this variation is thought to underlie differences in connectivity that impart specific functional specialization to distinct cortical areas. However, the degree to which cortical areas have a canonical versus noncanonical organization has proved difficult to reliably quantify. Single-nucleus and spatial transcriptomic methods ena...