作者：Braun, Emelie; Danan-Gotthold, Miri; Borm, Lars E.; Lee, Ka Wai; Vinsland, Elin; Lonnerberg, Peter; Hu, Lijuan; Li, Xiaofei; He, Xiaoling; Andrusivova, Zaneta; Lundeberg, Joakim; Barker, Roger A.; Arenas, Ernest; Sundstrom, Erik; Linnarsson, Sten
作者单位：Karolinska Institutet; Karolinska Institutet; University of Cambridge; Royal Institute of Technology; Weizmann Institute of Science
作者：Johansen, Nelson; Somasundaram, Saroja; Travaglini, Kyle J.; Yanny, Anna Marie; Shumyatcher, Maya; Casper, Tamara; Cobbs, Charles; Dee, Nick; Ellenbogen, Richard; Ferreira, Manuel; Goldy, Jeff; Guzman, Junitta; Gwinn, Ryder; Hirschstein, Daniel; Jorstad, Nikolas L.; Keene, C. Dirk; Ko, Andrew; Levi, Boaz P.; Ojemann, Jeffrey G.; Pham, Thanh; Shapovalova, Nadiya; Silbergeld, Daniel; Sulc, Josef; Torkelson, Amy; Tung, Herman; Smith, Kimberly; Lein, Ed S.; Bakken, Trygve E.; Hodge, Rebecca D.; Miller, Jeremy A.
作者单位：Allen Institute for Brain Science; Swedish Medical Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：INTRODUCTION Interindividual variation is a known feature of the human brain. In neocortical regions, broad classes of neurons and non-neuronal cells vary in abundance and gene expression in healthy adult humans, yet variation remains unexplored within finer divisions of cell types. Characterizing the effects of biological factors such as age, sex, ancestry, disease, or genetic variants on high-resolution cell types requires molecular profiling of single nuclei from large donor cohorts.RATIONA...
作者：Lee, Brian R.; Dalley, Rachel; Miller, Jeremy A.; Chartrand, Thomas; Close, Jennie; Mann, Rusty; Mukora, Alice; Ng, Lindsay; Alfiler, Lauren; Baker, Katherine; Bertagnolli, Darren; Brouner, Krissy; Casper, Tamara; Csajbok, Eva; Donadio, Nicholas; Driessens, Stan L. W.; Egdorf, Tom; Enstrom, Rachel; Galakhova, Anna A.; Gary, Amanda; Gelfand, Emily; Goldy, Jeff; Hadley, Kristen; Heistek, Tim S.; Hill, Dijon; Hou, Wen-Hsien; Johansen, Nelson; Jorstad, Nik; Kim, Lisa; Kocsis, Agnes Katalin; Kruse, Lauren; Kunst, Michael; Leon, Gabriela; Long, Brian; Mallory, Matthew; Maxwell, Michelle; Mcgraw, Medea; Mcmillen, Delissa; Melief, Erica J.; Molnar, Gabor; Mortrud, Marty T.; Newman, Dakota; Nyhus, Julie; Opitz-Araya, Ximena; Ozsvar, Attila; Pham, Trangthanh; Pom, Alice; Potekhina, Lydia; Rajanbabu, Ram; Ruiz, Augustin; Sunkin, Susan M.; Szoets, Ildiko; Taskin, Naz; Thyagarajan, Bargavi; Tieu, Michael; Trinh, Jessica; Vargas, Sara; Vumbaco, David; Waleboer, Femke; Walling-Bell, Sarah; Weed, Natalie; Williams, Grace; Wilson, Julia; Yao, Shenqin; Zhou, Thomas; Barzo, Pal; Bakken, Trygve; Cobbs, Charles; Dee, Nick; Ellenbogen, Richard G.; Esposito, Luke; Ferreira, Manuel; Gouwens, Nathan W.; Grannan, Benjamin; Gwinn, Ryder P.; Hauptman, Jason S.; Hodge, Rebecca; Jarsky, Tim; Keene, C. Dirk; Ko, Andrew L.; Korshoej, Anders Rosendal; Levi, Boaz P.; Meier, Kaare; Ojemann, Jeffrey G.; Patel, Anoop; Ruzevick, Jacob; Silbergeld, Daniel L.; Smith, Kimberly; Sorensen, Jens Christian; Waters, Jack; Zeng, Hongkui; Berg, Jim; Capogna, Marco; Goriounova, Natalia A.; Kalmbach, Brian; de Kock, Christiaan P. J.; Mansvelder, Huib D.; Sorensen, Staci A.; Tamas, Gabor; Lein, Ed S.; Ting, Jonathan T.
作者单位：Allen Institute for Brain Science; Szeged University; Vrije Universiteit Amsterdam; Aarhus University; University of Washington; University of Washington Seattle; Szeged University; Swedish Medical Center; University of Washington; University of Washington Seattle; Aarhus University; Aarhus University; Aarhus University; University of Washington; University of Washington Seattle
摘要：INTRODUCTION: Recent studies using single-cell transcriptomic analysis have shed new light on genetically defined cell types in the human brain. However, a deeper understanding of multimodal cellular properties, such as electrical activity and morphology, remains elusive and is central to understanding the role of distinct cell types in cognitive function and disease.RATIONALE: Understanding the fundamental properties of different cell types is important for gaining insights into their role in...
