2023

最新文章

• Makers of tiny, tunable points of light win chemistry Nobel AI翻译
  作者：Clery, Daniel; Kean, Sam
  摘要：Researchers share award for developing quantum dots, which fluoresce in vivid colors determined by their size
• A quest into the human brain AI翻译
  作者：Maroso, Mattia
• A comparative atlas of single-cell chromatin accessibility in the human brain AI翻译
  作者：Li, Yang Eric; Preissl, Sebastian; Miller, Michael; Johnson, Nicholas D.; Wang, Zihan; Jiao, Henry; Zhu, Chenxu; Wang, Zhaoning; Xie, Yang; Poirion, Olivier; Kern, Colin; Pinto-Duarte, Antonio; Tian, Wei; Siletti, Kimberly; Emerson, Nora; Osteen, Julia; Lucero, Jacinta; Lin, Lin; Yang, Qian; Zhu, Quan; Zemke, Nathan; Espinoza, Sarah; Yanny, Anna Marie; Nyhus, Julie; Dee, Nick; Casper, Tamara; Shapovalova, Nadiya; Hirschstein, Daniel; Hodge, Rebecca D.; Linnarsson, Sten; Bakken, Trygve; Levi, Boaz; Keene, C. Dirk; Shang, Jingbo; Lein, Ed; Wang, Allen; Behrens, M. Margarita; Ecker, Joseph R.; Ren, Bing
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Salk Institute; University of California System; University of California San Diego; Karolinska Institutet; Allen Institute for Brain Science; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Salk Institute; Washington University (WUSTL); University of Freiburg
  摘要：Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the regulatory programs governing cell identity and function remain unclear. Using a single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq), we explored open chromatin landscapes across 1.1 million cells in 42 brain regions from three adults. Integrating this data unveiled 107 distinct cell types and their specific utilizati...
• The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2 (vol 377, pg 960, 2022) AI翻译
  作者：Pekar, J. E.
• Probiotic-guided CAR-T cells for solid tumor targeting AI翻译
  作者：Vincent, Rosa L.; Gurbatri, Candice R.; Li, Fangda; Vardoshvili, Ana; Coker, Courtney; Im, Jongwon; Ballister, Edward R.; Rouanne, Mathieu; Savage, Thomas; de los Santos-Alexis, Kenia; Redenti, Andrew; Brockmann, Leonie; Komaranchath, Meghna; Arpaia, Nicholas; Danino, Tal
  作者单位：Columbia University; Columbia University; Columbia University; Columbia University
  摘要：A major challenge facing tumor-antigen targeting therapies such as chimeric antigen receptor (CAR)-T cells is the identification of suitable targets that are specifically and uniformly expressed on heterogeneous solid tumors. By contrast, certain species of bacteria selectively colonize immune-privileged tumor cores and can be engineered as antigen-independent platforms for therapeutic delivery. To bridge these approaches, we developed a platform of probiotic-guided CAR-T cells (ProCARs), in w...
• Exploiting the Marcus inverted region for first-row transition metal-based photoredox catalysis AI翻译
  作者：Chan, Amy Y.; Ghosh, Atanu; Yarranton, Jonathan T.; Twilton, Jack; Jin, Jian; Arias-Rotondo, Daniela M.; Sakai, Holt A.; McCusker, James K.; MacMillan, David W. C.
  作者单位：Princeton University; Michigan State University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Chinese Academy of Sciences, CAS
  摘要：Second- and third-row transition metal complexes are widely employed in photocatalysis, whereas earth-abundant first-row transition metals have found only limited use because of the prohibitively fast decay of their excited states. We report an unforeseen reactivity mode for productive photocatalysis that uses cobalt polypyridyl complexes as photocatalysts by exploiting Marcus inverted region behavior that couples increases in excited-state energies with increased excited-state lifetimes. Thes...
• The Assayer AI翻译
  作者：Gomez-Marin, Alex
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN)
  摘要：A foundational text that articulated the modern scientific method turns 400
• Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon AI翻译
  作者：Micali, Nicola; Ma, Shaojie; Li, Mingfeng; Kim, Suel-Kee; Mato-Blanco, Xoel; Sindhu, Suvimal Kumar; Arellano, Jon I.; Gao, Tianliuyun; Shibata, Mikihito; Gobeske, Kevin T.; Duque, Alvaro; Santpere, Gabriel; Sestan, Nenad; Rakic, Pasko
  作者单位：Yale University; Huazhong University of Science & Technology; Pompeu Fabra University; Barcelona Biomedical Research Park; Hospital del Mar Research Institute; Hospital del Mar; Yale University; Yale University; Yale University
  摘要：During early telencephalic development, intricate processes of regional patterning and neural stem cell (NSC) fate specification take place. However, our understanding of these processes in primates, including both conserved and species-specific features, remains limited. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We deciphered the molecular programs of the early organizing centers and their cross-talk with NSCs, revealing ...
• Plan to move Kew herbarium roils plant world AI翻译
  作者：Stokstad, Erik
  摘要：Botanists say transferring specimens to distant site is unnecessary and will hamper research
• Single-cell DNA methylation and 3D genome architecture in the human brain AI翻译
  作者：Tian, Wei; Zhou, Jingtian; Bartlett, Anna; Zeng, Qiurui; Liu, Hanqing; Castanon, Rosa G.; Kenworthy, Mia; Altshul, Jordan; Valadon, Cynthia; Aldridge, Andrew; Nery, Joseph R.; Chen, Huaming; Xu, Jiaying; Johnson, Nicholas D.; Lucero, Jacinta; Osteen, Julia K.; Emerson, Nora; Rink, Jon; Lee, Jasper; Li, Yang E.; Siletti, Kimberly; Liem, Michelle; Claffey, Naomi; O'Connor, Carolyn; Yanny, Anna Marie; Nyhus, Julie; Dee, Nick; Casper, Tamara; Shapovalova, Nadiya; Hirschstein, Daniel; Ding, Song-Lin; Hodge, Rebecca; Levi, Boaz P.; Keene, C. Dirk; Linnarsson, Sten; Lein, Ed; Ren, Bing; Behrens, M. Margarita; Ecker, Joseph R.
  作者单位：Salk Institute; University of California System; University of California San Diego; University of California System; University of California San Diego; Salk Institute; Ludwig Institute for Cancer Research; Karolinska Institutet; Salk Institute; Allen Institute for Brain Science; University of Washington; University of Washington Seattle; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Salk Institute; Howard Hughes Medical Institute
  摘要：IINTRODUCTION The intricate gene-regulatory mechanisms governing the diverse cell types within the brain are paramount to comprehending its functions in both health and disease. The recent surge in high-throughput epigenomic profiling has heralded groundbreaking revelations into these gene-regulatory frameworks. Particularly, DNA methylation, in conjunction with the three-dimensional (3D) chromatin formations, underpins the fundamentals of gene regulation. This study comprehensively analyzed D...