2023

最新文章

• A family portrait of human brain cells AI翻译
  作者：Weninger, Alyssa; Arlotta, Paola
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
• Risk-taking health agency places first bets AI翻译
  作者：Kaiser, Jocelyn
  摘要：ARPA-H aims to be unlike NIH, director says
• Boom-bust cycles in gray whales associated with dynamic and changing Arctic conditions AI翻译
  作者：Stewart, Joshua D.; Joyce, Trevor W.; Durban, John W.; Calambokidis, John; Fauquier, Deborah; Fearnbach, Holly; Grebmeier, Jacqueline M.; Lynn, Morgan; Manizza, Manfredi; Perryman, Wayne L.; Tinker, M. Tim; Weller, David W.
  作者单位：Oregon State University; National Oceanic Atmospheric Admin (NOAA) - USA; University System of Maryland; University of Maryland Center for Environmental Science; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California Santa Cruz
  摘要：Climate change is affecting a wide range of global systems, with polar ecosystems experiencing the most rapid change. Although climate impacts affect lower-trophic-level and short-lived species most directly, it is less clear how long-lived and mobile species will respond to rapid polar warming because they may have the short-term ability to accommodate ecological disruptions while adapting to new conditions. We found that the population dynamics of an iconic and highly mobile polar-associated...
• Improved medicine AI翻译
  作者：Cao, Bo
  作者单位：Xi'an Jiaotong University
• Sculptors of short light pulses win physics Nobel AI翻译
  作者：Cho, Adrian; Clery, Daniel
• Greater equity AI翻译
  作者：Khan, Muhammad Shehryar
  作者单位：Massachusetts Institute of Technology (MIT)
• FAMILY TIES AI翻译
  作者：Curry, Andrew
• Trust shapes views on science AI翻译
  作者：[Anonymous]
• Good reviews for eLife model AI翻译
  作者：[Anonymous]
• PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection AI翻译
  作者：Fisch, Daniel; Pfleiderer, Moritz M.; Anastasakou, Eleni; Mackie, Gillian M.; Wendt, Fabian; Liu, Xiangyang; Clough, Barbara; Lara-Reyna, Samuel; Encheva, Vesela; Snijders, Ambrosius P.; Bando, Hironori; Yamamoto, Masahiro; Beggs, Andrew D.; Mercer, Jason; Shenoy, Avinash R.; Wollscheid, Bernd; Maslowski, Kendle M.; Galej, Wojtek P.; Frickel, Eva-Maria
  作者单位：Francis Crick Institute; University of Birmingham; European Molecular Biology Laboratory (EMBL); University of Birmingham; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Institute of Bioinformatics; Francis Crick Institute; University of Osaka; University of Osaka; University of Birmingham; Imperial College London; Francis Crick Institute; University of Birmingham; Beatson Institute; University of Glasgow
  摘要：Disruption of cellular activities by pathogen virulence factors can trigger innate immune responses. Interferon-gamma (IFN-gamma)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense by attacking intracellular pathogens and by inducing programmed cell death. Working in human macrophages, we discovered that GBP1 expression in the absence of IFN-gamma killed the cells and induced Golgi fragmentation. IFN-gamma exposure improved macrophage...