作者：Lauck, Katherine S.; Ke, Alison; Olimpi, Elissa M.; Paredes, Daniel; Hood, Kees; Phillips, Thomas; Anderegg, William R. L.; Karp, Daniel S.
作者单位：University of California System; University of California Davis; Virginia Polytechnic Institute & State University; Universidad de Extremadura; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
摘要：Habitat conversion and climate change are fundamental drivers of biodiversity loss worldwide but are often analyzed in isolation. We used a continental-scale, decades-long database of more than 150,000 bird nesting attempts to explore how extreme heat affects avian reproduction in forests, grasslands, and agricultural and developed areas across the US. We found that in forests, extreme heat increased nest success, but birds nesting in agricultural settings were much less likely to successfully...
作者：Liu, Can; Todorova, Ralitsa; Tang, Wenbo; Oliva, Azahara; Fernandez-Ruiz, Antonio
作者单位：Cornell University
摘要：Episodic memory involves learning and recalling associations between items and their spatiotemporal context. Those memories can be further used to generate internal models of the world that enable predictions to be made. The mechanisms that support these associative and predictive aspects of memory are not yet understood. In this study, we used an optogenetic manipulation to perturb the sequential structure, but not global network dynamics, of place cells as rats traversed specific spatial tra...
作者：Aguirre, Lyndsey; Hendelman, Anat; Hutton, Samuel F.; McCandlish, David M.; Lippman, Zachary B.
作者单位：Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; State University System of Florida; University of Florida; Cold Spring Harbor Laboratory; Howard Hughes Medical Institute
摘要：Epistasis between genes is traditionally studied with mutations that eliminate protein activity, but most natural genetic variation is in cis-regulatory DNA and influences gene expression and function quantitatively. In this study, we used natural and engineered cis-regulatory alleles in a plant stem-cell circuit to systematically evaluate epistatic relationships controlling tomato fruit size. Combining a promoter allelic series with two other loci, we collected over 30,000 phenotypic data poi...
作者：Kviatcovsky, Denise; Valdes-Mas, Rafael; Federici, Sara; Elinav, Eran
作者单位：Weizmann Institute of Science; Helmholtz Association; German Cancer Research Center (DKFZ)
作者：Ahn, Green; Riley, Nicholas M.; Kamber, Roarke A.; Wisnovsky, Simon; von Hase, Salvador Moncayo; Bassik, Michael C.; Banik, Steven M.; Bertozzi, Carolyn R.
作者单位：Stanford University; Stanford University; Stanford University; University of British Columbia; Stanford University; Howard Hughes Medical Institute
摘要：Targeted protein degradation can provide advantages over inhibition approaches in the development of therapeutic strategies. Lysosome-targeting chimeras (LYTACs) harness receptors, such as the cation-independent mannose 6-phosphate receptor (CI-M6PR), to direct extracellular proteins to lysosomes. In this work, we used a genome-wide CRISPR knockout approach to identify modulators of LYTAC-mediated membrane protein degradation in human cells. We found that disrupting retromer genes improved tar...
作者：Stone, Richard; Ortega, Rodrigo Perez
摘要：Mexican biologist Rodrigo Medellin Legorreta is fighting political headwinds to preserve his country's natural heritage-and his own legacy
作者：Chartrand, Thomas; Dalley, Rachel; Close, Jennie; Goriounova, Natalia A.; Lee, Brian R.; Mann, Rusty; Miller, Jeremy A.; Molnar, Gabor; Mukora, Alice; Alfiler, Lauren; Baker, Katherine; Bakken, Trygve E.; Berg, Jim; Bertagnolli, Darren; Braun, Thomas; Brouner, Krissy; Casper, Tamara; Csajbok, Eva Adrienn; Dee, Nick; Egdorf, Tom; Enstrom, Rachel; Galakhova, Anna A.; Gary, Amanda; Gelfand, Emily; Goldy, Jeff; Hadley, Kristen; Heistek, Tim S.; Hill, Dijon; Jorstad, Nik; Kim, Lisa; Kocsis, Agnes Katalin; Kruse, Lauren; Kunst, Michael; Leon, Gabriela; Long, Brian; Mallory, Matthew; Mcgraw, Medea; Mcmillen, Delissa; Melief, Erica J.; Mihut, Norbert; Ng, Lindsay; Nyhus, Julie; Olah, Gaspar; Ozsvar, Attila; Omstead, Victoria; Peterfi, Zoltan; Pom, Alice; Potekhina, Lydia; Rajanbabu, Ramkumar; Rozsa, Marton; Ruiz, Augustin; Sandle, Joanna; Sunkin, Susan M.; Szots, Ildiko; Tieu, Michael; Toth, Martin; Trinh, Jessica; Vargas, Sara; Vumbaco, David; Williams, Grace; Wilson, Julia; Yao, Zizhen; Barzo, Pal; Cobbs, Charles; Ellenbogen, Richard G.; Esposito, Luke; Ferreira, Manuel; Gouwens, Nathan W.; Grannan, Benjamin; Gwinn, Ryder P.; Hauptman, Jason S.; Jarsky, Tim; Keene, C. Dirk; Ko, Andrew L.; Koch, Christof; Ojemann, Jeffrey G.; Patel, Anoop; Ruzevick, Jacob; Silbergeld, Daniel L.; Smith, Kimberly; Sorensen, Staci A.; Tasic, Bosiljka; Ting, Jonathan T.; Waters, Jack; de Kock, Christiaan P. J.; Mansvelder, Huib D.; Tamas, Gabor; Zeng, Hongkui; Kalmbach, Brian; Lein, Ed S.
作者单位：Allen Institute for Brain Science; Vrije Universiteit Amsterdam; Hungarian Academy of Sciences; Szeged University; University of Washington; University of Washington Seattle; Szeged University; Swedish Medical Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along wi...
