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作者:Wilcox, Christie
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作者:Ash, Caroline; Smith, Jesse; Jiang, Di; Uzogara, Ekeoma; Yeston, Jake S.; Grocholski, Brent; Stern, Peter; Ross, Sarah H.; Osborne, Ian S.
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作者:Baraka, Carey
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作者:Lelyveld, Victor S.; Fang, Ziyuan; Szostak, Jack W.
作者单位:Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of Chicago; University of Chicago; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Howard Hughes Medical Institute; Harvard University
摘要:A DNA polymerase with a single mutation and a divalent calcium cofactor catalyzes the synthesis of unnatural N3 -> P5 phosphoramidate (NP) bonds to form NP-DNA. However, this template-directed phosphoryl transfer activity remains orders of magnitude slower than native phosphodiester synthesis. Here, we used time-resolved x-ray crystallography to show that NP-DNA synthesis proceeds with a single detectable calcium ion in the active site. Using insights from isotopic and elemental effects, we pr...
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作者:Wood, Brian M.; Negrey, Jacob D.; Brown, Janine L.; Deschner, Tobias; Thompson, Melissa Emery; Gunter, Sholly; Mitani, John C.; Watts, David P.; Langergraber, Kevin E.
作者单位:University of California System; University of California Los Angeles; Max Planck Society; University of Arizona; Smithsonian Institution; Smithsonian National Zoological Park & Conservation Biology Institute; Max Planck Society; University Osnabruck; University of New Mexico; Yale University; University of Michigan System; University of Michigan; Arizona State University; Arizona State University-Tempe
摘要:Among mammals, post-reproductive life spans are currently documented only in humans and a few species of toothed whales. Here we show that a post-reproductive life span exists among wild chimpanzees in the Ngogo community of Kibale National Park, Uganda. Post-reproductive representation was 0.195, indicating that a female who reached adulthood could expect to live about one-fifth of her adult life in a post-reproductive state, around half as long as human hunter-gatherers. Post-reproductive fe...
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作者:Adamantidis, Antoine R.; de Lecea, Luis
作者单位:University of Bern; University Hospital of Bern; University of Bern; Stanford University
摘要:Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS (NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with cellular networks that support physiological and behavioral homeostasis. Here, we review the roles of sleep neurons of the hypothalamus in the homeostatic control of thermoregulation or goal-oriented behaviors during wakefulness. We address how hypothalamic circuits involved in opposing behaviors such as core body temperature and ...
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作者:Azevedo-Santos, Valter M.; Daga, Vanessa S.; Tonella, Livia H.; Ruaro, Renata; Arcifa, Marlene S.; Fearnside, Philip M.; Giarrizzo, Tommaso
作者单位:Universidade Federal do Tocantins (UFT); Universidade Federal do Parana; Universidade Tecnologica Federal do Parana; Pontificia Universidade Catolica do Parana; Universidade de Sao Paulo; Institute Nacional de Pesquisas da Amazonia; Universidade Federal do Ceara
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作者:Cant, Michael
作者单位:University of Exeter
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作者:Mohammadi, Alireza; Ranjbaran, Ali; Farhadinia, Mohammad S.; Vicente Lopez-Bao, Jose; Clevenger, Anthony Paul
作者单位:University of Kent; University of Oxford; Consejo Superior de Investigaciones Cientificas (CSIC)
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作者:Tyree, Timothy J.; Metke, Michael; Miller, Cory T.
作者单位:University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要:Faces and voices are the dominant social signals used to recognize individuals among primates. Yet, it is not known how these signals are integrated into a cross-modal representation of individual identity in the primate brain. We discovered that, although single neurons in the marmoset hippocampus exhibited selective responses when presented with the face or voice of a specific individual, a parallel mechanism for representing the cross-modal identities for multiple individuals was evident wi...