Sleep and the hypothalamus

• 成果类型: Review
• 署名作者: Adamantidis, Antoine R.; de Lecea, Luis
• 署名单位: University of Bern; University Hospital of Bern; University of Bern; Stanford University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-13500
• DOI: 10.1126/science.adh8285
• 发表日期: 2023-10-27
• 页码: 405-412
• 关键词: ventrolateral preoptic nucleus; slow-wave sleep; lateral hypothalamus; rem-sleep; feedforward inhibition; gabaergic neurons; orexin neurons; mch neurons; hypocretin; histamine

摘要

Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS (NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with cellular networks that support physiological and behavioral homeostasis. Here, we review the roles of sleep neurons of the hypothalamus in the homeostatic control of thermoregulation or goal-oriented behaviors during wakefulness. We address how hypothalamic circuits involved in opposing behaviors such as core body temperature and sleep compute conflicting information and provide a coherent vigilance state. Finally, we highlight some of the key unresolved questions and challenges, and the promise of a more granular view of the cellular and molecular diversity underlying the integrative role of the hypothalamus in physiological and behavioral homeostasis.