2023

最新文章

• Droplet-based forward genetic screening of astrocyte-microglia cross-talk AI翻译
  作者：Wheeler, Michael A.; Clark, Iain C.; Lee, Hong-Gyun; Li, Zhaorong; Linnerbauer, Mathias; Rone, Joseph M.; Blain, Manon; Akl, Camilo Faust; Piester, Gavin; Giovannoni, Federico; Charabati, Marc; Lee, Joon-Hyuk; Kye, Yoon-Chul; Choi, Joshua; Sanmarco, Liliana M.; Srun, Lena; Chung, Elizabeth N.; Flausino, Lucas E.; Andersen, Brian M.; Rothhammer, Veit; Yano, Hiroshi; Illouz, Tomer; Zandee, Stephanie E. J.; Daniel, Carolin; Artis, David; Prinz, Marco; Abate, Adam R.; Kuchroo, Vijay K.; Antel, Jack P.; Prat, Alexandre; Quintana, Francisco J.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Berkeley; McGill University; University of Rochester; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Erlangen Nuremberg; Cornell University; Universite de Montreal; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; Cornell University; Weill Cornell Medicine; University of Freiburg; University of Freiburg; University of Freiburg; University of Freiburg; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI)
  摘要：Cell-cell interactions in the central nervous system play important roles in neurologic diseases. However, little is known about the specific molecular pathways involved, and methods for their systematic identification are limited. Here, we developed a forward genetic screening platform that combines CRISPR-Cas9 perturbations, cell coculture in picoliter droplets, and microfluidic-based fluorescence-activated droplet sorting to identify mechanisms of cell-cell communication. We used SPEAC-seq ...
• Research ships retire and debut AI翻译
  作者：Brainard, Jeffrey
• Deep-sea impacts of climate interventions AI翻译
  作者：Levin, Lisa A.; Alfaro-Lucas, Joan M.; Colaco, Ana; Cordes, Erik E.; Craik, Neil; Danovaro, Roberto; Hoving, Henk-Jan; Ingels, Jeroen; Mestre, Nelia C.; Seabrook, Sarah; Thurber, Andrew R.; Vivian, Chris; Yasuhara, Moriaki
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Victoria; Universidade dos Acores; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Waterloo; Marche Polytechnic University; National Biodiversity Future Center; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; State University System of Florida; Florida State University; Universidade do Algarve; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Oregon State University; Oregon State University; University of Hong Kong; University of Hong Kong; University of Hong Kong; City University of Hong Kong
• Nations agree on long-sought high seas biodiversity treaty Pact sets framework for creating reserves and sharing profits AI翻译
  作者：Stokstad, Erik
• It sort of contradicts everything I would expect of hydrides. AI翻译
  作者：Boeri, Lilia
  作者单位：Sapienza University Rome
• Dwarfism and gigantism drive human-mediated extinctions on islands AI翻译
  作者：Rozzi, Roberto; Lomolino, Mark, V; van der Geer, Alexandra A. E.; Silvestro, Daniele; Lyons, S. Kathleen; Bover, Pere; Alcover, Josep A.; Benitez-Lopez, Ana; Tsai, Cheng-Hsiu; Fujita, Masaki; Kubo, Mugino O.; Ochoa, Janine; Scarborough, Matthew E.; Turvey, Samuel T.; Zizka, Alexander; Chase, Jonathan M.
  作者单位：German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leibniz Institut fur Evolutions und Biodiversitatsforschung; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry; Naturalis Biodiversity Center; University of Fribourg; Swiss Institute of Bioinformatics; University of Gothenburg; University of Gothenburg; University of Nebraska System; University of Nebraska Lincoln; University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); University of Granada; National Taiwan University; National Taiwan University; National Museum of Nature and Science; University of Tokyo; University of the Philippines System; University of the Philippines Diliman; University of Cape Town; Zoological Society of London; Naturalis Biodiversity Center; Philipps University Marburg; Martin Luther University Halle Wittenberg; Martin Luther University Halle Wittenberg
  摘要：Islands have long been recognized as distinctive evolutionary arenas leading to morphologically divergent species, such as dwarfs and giants. We assessed how body size evolution in island mammals may have exacerbated their vulnerability, as well as how human arrival has contributed to their past and ongoing extinctions, by integrating data on 1231 extant and 350 extinct species from islands and paleo islands worldwide spanning the past 23 million years. We found that the likelihood of extincti...
• High level of novelty under the hood of convergent evolution AI翻译
  作者：Belleghem, Steven M. Van; Ruggieri, Angelo A.; Concha, Carolina; Livraghi, Luca; Hebberecht, Laura; Rivera, Edgardo Santiago; Ogilvie, James G.; Hanly, Joseph J.; Warren, Ian A.; Planas, Silvia; Ortiz-Ruiz, Yadira; Reed, Robert; Lewis, James J.; Jiggins, Chris D.; Counterman, Brian A.; McMillan, W. Owen; Papa, Riccardo
  作者单位：University of Puerto Rico; University of Puerto Rico Medical Sciences Campus; KU Leuven; Smithsonian Institution; Smithsonian Tropical Research Institute; George Washington University; University of Bristol; University of Cambridge; University of Bayreuth; Auburn University System; Auburn University; University of Puerto Rico; Cornell University; Clemson University; University of Puerto Rico; University of Puerto Rico Medical Sciences Campus
  摘要：Little is known about the extent to which species use homologous regulatory architectures to achieve phenotypic convergence. By characterizing chromatin accessibility and gene expression in developing wing tissues, we compared the regulatory architecture of convergence between a pair of mimetic butterfly species. Although a handful of color pattern genes are known to be involved in their convergence, our data suggest that different mutational paths underlie the integration of these genes into ...
• Astronomy pioneer might have been near-sighted AI翻译
  作者：Brainard, Jeffrey
• Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase AI翻译
  作者：Hicks, Kevin G.; Cluntun, Ahmad A.; Schubert, Heidi L.; Hackett, Sean R.; Berg, Jordan A.; Leonard, Paul G.; Aleixo, Mariana A. Ajalla; Zhou, Youjia; Bott, Alex J.; Salvatore, Sonia R.; Chang, Fei; Blevins, Aubrie; Barta, Paige; Tilley, Samantha; Leifer, Aaron; Guzman, Andrea; Arok, Ajak; Fogarty, Sarah; Winter, Jacob M.; Ahn, Hee-Chul; Allen, Karen N.; Block, Samuel; Cardoso, Iara A.; Ding, Jianping; Dreveny, Ingrid; Gasper, William C.; Ho, Quinn; Matsuura, Atsushi; Palladino, Michael J.; Prajapati, Sabin; Sun, Pengkai; Tittmann, Kai; Tolan, Dean R.; Unterlass, Judith; VanDemark, Andrew P.; Vander Heiden, Matthew G.; Webb, Bradley A.; Yun, Cai-Hong; Zhao, Pengkai; Wang, Bei; Schopter, Francisco J.; Hill, Christopher P.; Nonato, Maria Cristina; Muller, Florian L.; Cox, James E.; Rutter, Jared
  作者单位：Utah System of Higher Education; University of Utah; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Universidade de Sao Paulo; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Howard Hughes Medical Institute; Utah System of Higher Education; University of Utah; Dongguk University; Boston University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Center for Excellence in Molecular Cell Science, CAS; University of Nottingham; Boston University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Gottingen; Max Planck Society; Karolinska Institutet; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; West Virginia University; Peking University; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; University of Texas Southwestern Medical Center; Scripps Research Institute; Baylor University
  摘要：Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the discovery of allostery systematically (MIDAS) to identify such interactions. Analysis of 33 enzymes from human carbohydrate metabolism identified 830 protein-metabolite interactions, including known regulat...
• AI tools can improve equity in science AI翻译
  作者：Berdejo-Espinola, Violeta; Amano, Tatsuya
  作者单位：University of Queensland; University of Queensland