2023

最新文章

• Evolutionary-scale prediction of atomic-level protein structure with a language model AI翻译
  作者：Lin, Zeming; Akin, Halil; Rao, Roshan; Hie, Brian; Zhu, Zhongkai; Lu, Wenting; Smetanin, Nikita; Verkuil, Robert; Kabeli, Ori; Shmueli, Yaniv; Costa, Allan dos Santos; Fazel-Zarandi, Maryam; Sercu, Tom; Candido, Salvatore; Rives, Alexander
  作者单位：New York University; Stanford University; Massachusetts Institute of Technology (MIT)
  摘要：Recent advances in machine learning have leveraged evolutionary information in multiple sequence alignments to predict protein structure. We demonstrate direct inference of full atomic-level protein structure from primary sequence using a large language model. As language models of protein sequences are scaled up to 15 billion parameters, an atomic-resolution picture of protein structure emerges in the learned representations. This results in an order-of-magnitude acceleration of high-resoluti...
• Biden backs science in 2024 spending blueprint But Congress will have its own views on setting funding levels for research agencies AI翻译
  作者：Mervis, Jeffrey
• Let's change what's possible AI翻译
  作者：Prabhakar, Arati
• Outdated cap on NIH research grant budgets AI翻译
  作者：Hawk, Larry W.
  作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY
• Dance about materials wins prize AI翻译
  作者：Brainard, Jeffrey
  摘要：NEUTRON RESEARCH | This week, regulators gave the go-ahead to restart a small U.S. research reactor, 2 years after an accident shut it down and cut almost by half the nation's capacity to use neutrons to study materials. The February 2021 incident at the 20-megawatt, neutrongenerating reactor at the National Institute of Standards and Technology (NIST) in Gaithersburg, Maryland, occurred when one of its 30 rodlike, uranium-filled fuel pins popped out of place, overheated, and partially melted....
• Straight from the heart AI翻译
  作者：Leslie, Mitch
• A cryptic clue to neurodegeneration? Antisense oligonucleotides rescue cryptic RNA splicing and neuron regeneration AI翻译
  作者：O'Brien, Niamh; Mizielinska, Sarah
  作者单位：University of London; King's College London
• Schizophrenia pinpointed as a key factor in heat deaths The mental illness tripled the risk of death during a searing 2021 heat wave, researchers find AI翻译
  作者：Cornwall, Warren
• Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex AI翻译
  作者：Ehrmann, Julian F.; Grabarczyk, Daniel B.; Heinke, Maria; Deszcz, Luiza; Kurzbauer, Robert; Hudecz, Otto; Shulkina, Alexandra; Gogova, Rebeca; Meinhart, Anton; Versteeg, Gijs A.; Clausen, Tim
  作者单位：Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Medical University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); Medical University of Vienna
  摘要：Inhibitor of apoptosis proteins (IAPs) bind to pro-apoptotic proteases, keeping them inactive and preventing cell death. The atypical ubiquitin ligase BIRC6 is the only essential IAP, additionally functioning as a suppressor of autophagy. We performed a structure-function analysis of BIRC6 in complex with caspase-9, HTRA2, SMAC, and LC3B, which are critical apoptosis and autophagy proteins. Cryo-electron microscopy structures showed that BIRC6 forms a megadalton crescent shape that arcs around...
• Mitigate diseases to protect biodiversity AI翻译
  作者：Plewnia, Amadeus; Boening, Philipp; Loetters, Stefan
  作者单位：Universitat Trier