作者：Baughn, Michael W.; Melamed, Ze'ev; Lopez-Erauskin, Jone; Beccari, Melinda S.; Ling, Karen; Zuberi, Aamir; Presa, Maximilliano; Gonzalo-Gil, Elena; Maimon, Roy; Vazquez-Sanchez, Sonia; Chaturvedi, Som; Bravo-Hernandez, Mariana; Taupin, Vanessa; Moore, Stephen; Artates, Jonathan W.; Acks, Eitan; Ndayambaje, I. Sandra; Quadros, Ana R. Agra de Almeida; Jafar-Nejad, Paayman; Rigo, Frank; Bennett, C. Frank; Lutz, Cathleen; Lagier-Tourenne, Clotilde; Cleveland, Don W.
作者单位：University of California System; University of California San Diego; Ludwig Institute for Cancer Research; University of California System; University of California San Diego; Hebrew University of Jerusalem; Ionis Pharmaceuticals, Inc.; Jackson Laboratory; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Loss of nuclear TDP-43 is a hallmark of neurodegeneration in TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 mislocalization results in cryptic splicing and polyadenylation of pre-messenger RNAs (pre-mRNAs) encoding stathmin-2 (also known as SCG10), a protein that is required for axonal regeneration. We found that TDP-43 binding to a GU-rich region sterically blocked recognition of the cryptic 3 ' splice site in STMN2 pre-mRNA. Ta...
作者：Krypotou, Emilia; Townsend, Guy E.; Gao, Xiaohui; Tachiyama, Shoichi; Liu, Jun; Pokorzynski, Nick D.; Goodman, Andrew L.; Groisman, Eduardo A.
作者单位：Yale University; Yale University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health
摘要：Therapeutic manipulation of the gut microbiota holds great potential for human health. The mechanisms bacteria use to colonize the gut therefore present valuable targets for clinical intervention. We now report that bacteria use phase separation to enhance fitness in the mammalian gut. We establish that the intrinsically disordered region (IDR) of the broadly and highly conserved transcription termination factor Rho is necessary and sufficient for phase separation in vivo and in vitro in the h...
