作者:Xie, Guohui; Du, Xuan; Hu, Hongmiao; Li, Sisi; Cao, Xiaofeng; Jacobsen, Steven E.; Du, Jiamu
作者单位:Southern University of Science & Technology; Shenzhen University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Howard Hughes Medical Institute
摘要:In addition to the conserved RNA polymerases Ito III (Pols Ito III) in eukaryotes, two atypical polymerases, Pols IV and V, specifically produce noncoding RNA in the RNA-directed DNA methylation pathway in plants. Here, we report on the structures of cauliflower Pol V in the free and elongation conformations. A conserved tyrosine residue of NRPE2 stacks with a double -stranded DNA branch of the transcription bubble to potentially attenuate elongation by inducing transcription stalling. The non...
作者:Couzin-Frankel, Jennifer
作者:Johnson, Kirk R.; Owens, Ian F. P.
作者单位:Smithsonian Institution; Cornell University
作者:Williams, Brooke A.; Morgans, Courtney; Rhodes, Jonathan R.
作者单位:University of Queensland; University of Queensland
作者:DeAngelis, Ross S.; Hofmann, Hans A.
作者单位:University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin