作者：Smith, Michael; Cacucciolo, Vito; Shea, Herbert
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Politecnico di Bari
摘要：Incorporating pressurized fluidic circuits into textiles can enable muscular support, thermoregulation, and haptic feedback in a convenient wearable form factor. However, conventional rigid pumps, with their associated noise and vibration, are unsuitable for most wearables. We report fluidic pumps in the form of stretchable fibers. This allows pressure sources to be integrated directly into textiles, enabling untethered wearable fluidics. Our pumps consist of continuous helical electrodes embe...
作者：Taylor, William Timothy Treal; Librado, Pablo; Icu, Mila Hunska Tasunke; Gover, Carlton Shield Chief; Arterberry, Jimmy; Win, Anpetu Luta; Nujipi, Akil; Omniya, Tanka; Gonzalez, Mario; Means, Bill; Crane, Sam High; Mazasu; Knife, Barbara Dull; Win, Wakihyala; Collin, Cruz Tecumseh; Ward, Chance; Pasqual, Theresa A.; Chauvey, Lorelei; Tonasso-Calviere, Laure; Schiavinato, Stephanie; Seguin-Orlando, Andaine; Fages, Antoine; Khan, Naveed; Der Sarkissian, Clio; Liu, Xuexue; Wagner, Stefanie; Leonard, Beth Ginondidoy; Manzano, Bruce L.; O'Malley, Nancy; Leonard, Jennifer A.; Bernaldez-Sanchez, Eloisa; Barrey, Eric; Charliquart, Lea; Robbe, Emilie; Denoblet, Thibault; Gregersen, Kristian; Vershinina, Alisa O.; Weinstock, Jaco; Sikanjic, Petra Rajit; Mashkour, Marjan; Shingiray, Irina; Aury, Jean-Marc; Perdereau, Aude; Alquraishi, Saleh; Alfarhan, Ahmed H.; Al-Rasheid, Khaled A. S.; Vukicevit, Tajana Trbojevit; Buric, Marcel; Sauer, Eberhard; Lucas, Mary; Brenner-Coltrain, Joan; Bozell, John R.; Thornhill, Cassidee A.; Monagle, Victoria; Perri, Angela; Newton, Cody; Hall, W. Eugene; Conver, Joshua L.; Le Roux, Petrus; Buckser, Sasha G.; Gabe, Caroline; Belardi, Juan Bautista; Barron-Ortiz, Christina I.; Hart, Isaac A.; Ryder, Christina; Sponheimer, Matthew; Shapiro, Beth; Southon, John; Hibbs, Joss; Faulkner, Charlotte; Outram, Alan; Rosa, Laura Patterson; Palermo, Katelyn; Sole, Marina; William, Alice; McCrory, Wayne; Lindgren, Gabriella; Brooks, Samantha; Eche, Camille; Donnadieu, Cecile; Bouchez, Olivier; Wincker, Patrick; Hodgins, Gregory; Trabert, Sarah; Bethke, Brandi; Roberts, Patrick; Jones, Emily Lena; Collin, Yvette Running Horse; Orlando, Ludovic
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Universite de Toulouse; Universite Toulouse III - Paul Sabatier; University of Basel; Abdul Wali Khan University; Alaska Pacific University; Western Kentucky University; University of Kentucky; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Universite Paris Saclay; INRAE; AgroParisTech; University of California System; University of California Santa Cruz; University of Southampton; Institute for Anthropological Research Zagreb; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); University of Oxford; University of Oxford; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CEA; Taif University; King Saud University; Princess Nourah bint Abdulrahman University; Almaarefa University; University of Zagreb; University of Zagreb; University of Edinburgh; Max Planck Society; Utah System of Higher Education; University of Utah; University of Wyoming; University of New Mexico; Texas A&M University System; Texas A&M University College Station; University of Arizona; University of Colorado System; University of Colorado Boulder; University of Cape Town; Adams State University; Adams State University; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad Nacional de la Patagonia San Juan Bosco; University of California System; University of California Santa Cruz; Howard Hughes Medical Institute; University of California System; University of California Santa Cruz; University of California System; University of California Irvine; University of Exeter; Texas State University System; Sul Ross State University; Florida Department of Health; Swedish University of Agricultural Sciences; KU Leuven; State University System of Florida; University of Florida; INRAE; University of Arizona; University of Oklahoma System; University of Oklahoma - Norman; University of Oklahoma System; University of Oklahoma - Norman; Max Planck Society
摘要：The horse is central to many Indigenous cultures across the American Southwest and the Great Plains. However, when and how horses were first integrated into Indigenous lifeways remain contentious, with extant models derived largely from colonial records. We conducted an interdisciplinary study of an assemblage of historic archaeological horse remains, integrating genomic, isotopic, radiocarbon, and paleopathological evidence. Archaeological and modern North American horses show strong Iberian ...
作者：Palmer, Duncan S.; Zhou, Wei; Abbott, Liam; Wigdor, Emilie M.; Baya, Nikolas; Churchhouse, Claire; Seed, Cotton; Poterba, Tim; King, Daniel; Kanai, Masahiro; Bloemendal, Alex; Neale, Benjamin M.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Wellcome Trust Sanger Institute; University of Oxford
摘要：Classical statistical genetics theory defines dominance as any deviation from a purely additive, or dosage, effect of a genotype on a trait, which is known as the dominance deviation. Dominance is well documented in plant and animal breeding. Outside of rare monogenic traits, however, evidence in humans is limited. We systematically examined common genetic variation across 1060 traits in a large population cohort (UK Biobank, N = 361,194 samples analyzed) for evidence of dominance effects. We ...
作者：Nolan, Trevor M.; Vukasinovic, Nemanja; Hsu, Che-Wei; Zhang, Jingyuan; Vanhoutte, Isabelle; Shahan, Rachel; Taylor, Isaiah W.; Greenstreet, Laura; Heitz, Matthieu; Afanassiev, Anton; Wang, Ping; Szekely, Pablo; Brosnan, Aiden; Yin, Yanhai; Schiebinger, Geoffrey; Ohler, Uwe; Russinova, Eugenia; Benfey, Philip N.
作者单位：Duke University; Ghent University; Flanders Institute for Biotechnology (VIB); Humboldt University of Berlin; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Howard Hughes Medical Institute; Duke University; University of British Columbia; Iowa State University; Humboldt University of Berlin
摘要：Brassinosteroids are plant steroid hormones that regulate diverse processes, such as cell division and cell elongation, through gene regulatory networks that vary in space and time. By using time series single-cell RNA sequencing to profile brassinosteroid-responsive gene expression specific to different cell types and developmental stages of the Arabidopsis root, we identified the elongating cortex as a site where brassinosteroids trigger a shift from proliferation to elongation associated wi...
作者：Laboute, Thibaut; Zucca, Stefano; Holcomb, Matthew; Patil, Dipak N.; Garza, Chris; Wheatley, Brittany A.; Roy, Raktim N.; Forli, Stefano; Martemyanov, Kirill A.
作者单位：State University System of Florida; University of Florida; Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology; Scripps Research Institute; State University System of Florida; University of Florida; Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology; Eli Lilly
摘要：Glycine is a major neurotransmitter involved in several fundamental neuronal processes. The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine is unknown. We identified an orphan G protein-coupled receptor, GPR158, as a metabotropic glycine receptor (mGlyR). Glycine and a related modulator, taurine, directly bind to a Cache domain of GPR158, and this event inhibits the activity of the intracellular signaling complex regulator of G protein signaling 7-G prot...
