2023

最新文章

• NIH ends funding for troubled monkey lab AI翻译
  作者：Brainard, Jeffrey
• Advancing equity and integrity in research AI翻译
  作者：McIntosh, Leslie; Vitale, Cynthia Hudson
• Recruited macrophages elicit atrial fibrillation AI翻译
  作者：Hulsmans, Maarten; Schloss, Maximilian J.; Lee, I-Hsiu; Bapat, Aneesh; Iwamoto, Yoshiko; Vinegoni, Claudio; Paccalet, Alexandre; Yamazoe, Masahiro; Grune, Jana; Pabel, Steffen; Momin, Noor; Seung, Hana; Kumowski, Nina; Pulous, Fadi E.; Keller, Daniel; Bening, Constanze; Green, Ursula; Lennerz, Jochen K.; Mitchell, Richard N.; Lewis, Andrew; Casadei, Barbara; Iborra-Egea, Oriol; Bayes-Genis, Antoni; Sossalla, Samuel; Ong, Chin Siang; Pierson, Richard N.; Aster, Jon C.; Rohde, David; Wojtkiewicz, Gregory R.; Weissleder, Ralph; Swirski, Filip K.; Tellides, George; Tolis, George, Jr.; Melnitchouk, Serguei; Milan, David J.; Ellinor, Patrick T.; Naxerova, Kamila; Nahrendorf, Matthias
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Regensburg; University of Wurzburg; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Oxford; University of Oxford; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; Justus Liebig University Giessen; German Centre for Cardiovascular Research; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Yale University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Wurzburg
  摘要：Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We deciphered how immune and stromal cells contribute to atrial fibrillation. Single-cell transcriptomes from human atria documented inflammatory monocyte and SPP1(+) macrophage expansion in atrial fibrillation. Combining hypertension, obesity, and mitral valve regurgitation (HOMER) in mice elicited enlarged, fibrosed, and fibrillation-prone atria. Single-cell transcriptomes from HOMER mouse atria recap...
• Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila AI翻译
  作者：Jacobs, Jelle; Pagani, Michaela; Wenzl, Christoph; Stark, Alexander
  作者单位：Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); Medical University of Vienna; Vienna Biocenter (VBC)
  摘要：Gene expression is controlled by the precise activation and repression of transcription. Repression is mediated by specialized transcription factors (TFs) that recruit co-repressors (CoRs) to silence transcription, even in the presence of activating cues. However, whether CoRs can dominantly silence all enhancers or display distinct specificities is unclear. In this work, we report that most enhancers in Drosophila can be repressed by only a subset of CoRs, and enhancers classified by CoR sens...
• Engineering ligand reactivity enables high-temperature operation of stable perovskite solar cells AI翻译
  作者：Park, So Min; Wei, Mingyang; Xu, Jian; Atapattu, Harindi R.; Eickemeyer, Felix T.; Darabi, Kasra; Grater, Luke; Yang, Yi; Liu, Cheng; Teale, Sam; Chen, Bin; Chen, Hao; Wang, Tonghui; Zeng, Lewei; Maxwell, Aidan; Wang, Zaiwei; Rao, Keerthan R.; Cai, Zhuoyun; Zakeeruddin, Shaik M.; Pham, Jonathan T.; Risko, Chad M.; Amassian, Aram; Kanatzidis, Mercouri G.; Graham, Kenneth R.; Gratzel, Michael; Sargent, Edward H.
  作者单位：University of Toronto; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Kentucky; North Carolina State University; North Carolina State University; Northwestern University; University of Kentucky; Northwestern University
  摘要：Perovskite solar cells (PSCs) consisting of interfacial two- and three-dimensional heterostructures that incorporate ammonium ligand intercalation have enabled rapid progress toward the goal of uniting performance with stability. However, as the field continues to seek ever-higher durability, additional tools that avoid progressive ligand intercalation are needed to minimize degradation at high temperatures. We used ammonium ligands that are nonreactive with the bulk of perovskites and investi...
• Lava outburst may have led to Snowball Earth AI翻译
  作者：Wei-Haas, Maya
  摘要：Eruption dates suggest chemical weathering of rocks triggered plunging temperatures
• Giant NSF grants aim to revitalize left-behind regions AI翻译
  作者：Mervis, Jeffrey
  摘要：34 teams make first cut for $160 million awards to drive economic and social change
• AI in search of human help AI翻译
  作者：Heim, Ashley Barbara; Bharani, Tina; Konstantinides, Nikos; Powell, Jackson Ross; Srivastava, Sudhakar; Cao, Xiangkun Elvis; Agarwal, Divyansh; Waiho, Khor; Lin, Teng-Jui; Virgueez, Edgar; Strielkowski, Wadim; Uzonyi, Anna
  作者单位：Cornell University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Universite Paris Cite; University of Pennsylvania; Banaras Hindu University (BHU); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Washington; University of Washington Seattle; Carnegie Institution for Science; University of California System; University of California Berkeley; Czech University of Life Sciences Prague; Weizmann Institute of Science
• The central role of density functional theory in the AI age AI翻译
  作者：Huang, Bing; von Rudorff, Guido Falk; von Lilienfeld, O. Anatole
  作者单位：University of Vienna; Universitat Kassel; Vector Institute for Artificial Intelligence; University of Toronto; University of Toronto; University of Toronto; Technical University of Berlin
  摘要：Density functional theory (DFT) plays a pivotal role in chemical and materials science because of its relatively high predictive power, applicability, versatility, and computational efficiency. We review recent progress in machine learning (ML) model developments, which have relied heavily on DFT for synthetic data generation and for the design of model architectures. The general relevance of these developments is placed in a broader context for chemical and materials sciences. DFT-based ML mo...
• Do we want less automation? AI翻译
  作者：Agrawal, Ajay; Gans, Joshua S.; Goldfarb, Avi
  作者单位：University of Toronto
  摘要：Impressive achievements made through artificial intelligence (AI) innovations in automating the tasks required in many jobs have reinforced concerns about labor market disruption and increased income inequality. This has motivated calls for change in the direction of AI innovation from being guided by task automation to instead focusing on labor augmentation (1). But task automation and labor augmentation are not polar opposites. Instead, automation of some tasks can lead to augmentation of la...