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作者：Zhu, Ziai; Sun, Xin
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：The respiratory tract is essential for breathing but is also important for detecting and responding to inhaled harmful (noxious) stimuli, such as pollutants, pathogens, water, and acid. Neuroendocrine cells (NECs)-rare epithelial cells that share characteristics with neurons-are an integral component of this sensory surveillance system ( 1 ). Although NECs have been proposed to act as airway sentinels capable of perceiving chemical and mechanical cues and can secrete signals to relay informati...
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作者：Avdellidou, Chrysa; Delbo', Marco; Nesvorny, David; Walsh, Kevin J.; Morbidelli, Alessandro
作者单位：Universite Cote d'Azur; Observatoire de la Cote d'Azur; University of Leicester; Southwest Research Institute; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; College de France
摘要：The giant planets of the Solar System formed on initially compact orbits, which transitioned to the current wider configuration by means of an orbital instability. The timing of that instability is poorly constrained. In this work, we use dynamical simulations to demonstrate that the instability implanted planetesimal fragments from the terrestrial planet region into the asteroid main belt. We use meteorite data to show that the implantation occurred >60 million years (Myr) after the Solar Sys...
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作者：Wen, Tai-Hao; Hung, Je-Min; Huang, Wei-Hsing; Jhang, Chuan-Jia; Lo, Yun-Chen; Hsu, Hung-Hsi; Ke, Zhao-En; Chen, Yu-Chiao; Chin, Yu-Hsiang; Su, Chin-, I; Khwa, Win-San; Lo, Chung-Chuan; Liu, Ren-Shuo; Hsieh, Chih-Cheng; Tang, Kea-Tiong; Ho, Mon-Shu; Chou, Chung-Cheng; Chih, Yu-Der; Chang, Tsung-Yung Jonathan; Chang, Meng-Fan
作者单位：Taiwan Semiconductor Manufacturing Company
摘要：Artificial intelligence (AI) edge devices prefer employing high-capacity nonvolatile compute-in-memory (CIM) to achieve high energy efficiency and rapid wakeup-to-response with sufficient accuracy. Most previous works are based on either memristor-based CIMs, which suffer from accuracy loss and do not support training as a result of limited endurance, or digital static random-access memory (SRAM)-based CIMs, which suffer from large area requirements and volatile storage. We report an AI edge p...
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作者：Casanova, Jean-Laurent; MacMicking, John D.; Nathan, Carl F.
作者单位：Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Yale University; Yale University; Yale University; Yale University; Howard Hughes Medical Institute; Cornell University; Weill Cornell Medicine
摘要：Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon-gamma (IFN-gamma), a protein secreted by lymphocytes. Forty years ago, IFN-gamma was identified as a macrophage-activating factor, and, in recent years, there has been...
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作者：Lemaire, Patrick; Massol, Francois
摘要：France is at a crossroads, facing environmental and social challenges that are profoundly altering its society. Yet, the French government keeps prioritizing short-term political gains over long-term evidence-based planning for major transitions that France, like most countries, will undergo over the next 20 years. There is an urgent need for France to implement long-term science-informed policy-making.
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作者：Peng, Yangfan; Bjelde, Antje; Aceituno, Pau Vilimelis; Mittermaier, Franz X.; Planert, Henrike; Grosser, Sabine; Onken, Julia; Faust, Katharina; Kalbhenn, Thilo; Simon, Matthias; Radbruch, Helena; Fidzinski, Pawel; Schmitz, Dietmar; Alle, Henrik; Holtkamp, Martin; Vida, Imre; Grewe, Benjamin F.; Geiger, Joerg R. P.
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Evangelical Hospital Bethel (EvKB) - House Gilead I; University of Bielefeld; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
摘要：The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies of cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to the evolutionarily expanded human cortex is unclear. We studied network properties within the human temporal cortex using samples obtained from brain surgery. We analyzed multineuron patch-clamp recordings in layer 2-3 pyramidal neurons and ide...
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作者：Ellis, Erle C.
作者单位：University System of Maryland; University of Maryland Baltimore County; University of Oxford
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作者：Foutty, Benjamin A.; Kometter, Carlos R.; Devakul, Trithep; Reddy, Aidan P.; Watanabe, Kenji; Taniguchi, Takashi; Fu, Liang; Feldman, Benjamin E.
作者单位：Stanford University; Massachusetts Institute of Technology (MIT); National Institute for Materials Science; National Institute for Materials Science; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory
摘要：Semiconductor moire superlattices have been shown to host a wide array of interaction-driven ground states. However, twisted homobilayers have been difficult to study in the limit of large moire wavelengths, where interactions are most dominant. In this study, we conducted local electronic compressibility measurements of twisted bilayer WSe2 (tWSe(2)) at small twist angles. We demonstrated multiple topological bands that host a series of Chern insulators at zero magnetic field near a magic ang...
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作者：Zhang, Liming; Wang, Daxi; Shi, Peibo; Li, Juzhen; Niu, Jichen; Chen, Jielong; Wang, Gang; Wu, Linjuan; Chen, Lu; Yang, Zhenxing; Li, Susheng; Meng, Jinxin; Ruan, Fangchao; He, Yuwen; Zhao, Hailong; Ren, Zirui; Wang, Yibaina; Liu, Yang; Shi, Xiaolu; Wang, Yunfu; Liu, Qiyong; Li, Junhua; Wang, Penghua; Wang, Jinglin; Zhu, Yibin; Cheng, Gong
作者单位：Tsinghua University; Shenzhen Bay Laboratory; Shenzhen Center for Disease Control & Prevention (SZCDC); Beijing Genomics Institute (BGI); Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Kunming Medical University; Hubei University of Medicine; Chinese Center for Disease Control & Prevention; National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention; University of Connecticut
摘要：The commensal microbiota of the mosquito gut plays a complex role in determining the vector competence for arboviruses. In this study, we identified a bacterium from the gut of field Aedes albopictus mosquitoes named Rosenbergiella sp. YN46 (Rosenbergiella_YN46) that rendered mosquitoes refractory to infection with dengue and Zika viruses. Inoculation of 1.6 x 10(3) colony forming units (CFUs) of Rosenbergiella_YN46 into A. albopictus mosquitoes effectively prevents viral infection. Mechanisti...
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作者：Cohen, Jon
摘要：Moderna's pause on Kenya project highlights difficulties in creating a competitive vaccine sector on the continent
