Interferon-γ and infectious diseases: Lessons and prospects

• 成果类型: Review
• 署名作者: Casanova, Jean-Laurent; MacMicking, John D.; Nathan, Carl F.
• 署名单位: Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Yale University; Yale University; Yale University; Yale University; Howard Hughes Medical Institute; Cornell University; Weill Cornell Medicine
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-8770
• DOI: 10.1126/science.adl2016
• 发表日期: 2024-04-19
• 关键词: human mononuclear phagocytes; bacille calmette-guerin; ifn-gamma; human macrophages; t-lymphocytes; i interferon; mycobacterial disease; transcription factor; effector mechanisms; toxoplasma-gondii

摘要

Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon-gamma (IFN-gamma), a protein secreted by lymphocytes. Forty years ago, IFN-gamma was identified as a macrophage-activating factor, and, in recent years, there has been a resurgent interest in IFN-gamma biology and its role in human defense. Here we assess the current understanding of IFN-gamma, revisit its designation as an interferon, and weigh its prospects as a therapeutic against globally pervasive microbial pathogens.