Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit
成果类型：
Article
署名作者：
Peng, Yangfan; Bjelde, Antje; Aceituno, Pau Vilimelis; Mittermaier, Franz X.; Planert, Henrike; Grosser, Sabine; Onken, Julia; Faust, Katharina; Kalbhenn, Thilo; Simon, Matthias; Radbruch, Helena; Fidzinski, Pawel; Schmitz, Dietmar; Alle, Henrik; Holtkamp, Martin; Vida, Imre; Grewe, Benjamin F.; Geiger, Joerg R. P.
署名单位：
Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Evangelical Hospital Bethel (EvKB) - House Gilead I; University of Bielefeld; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-8772
DOI：
10.1126/science.adg8828
发表日期：
2024-04-19
页码：
338-343
关键词：
computation
network
ORGANIZATION
neocortex
geometry
memory
state
摘要：
The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies of cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to the evolutionarily expanded human cortex is unclear. We studied network properties within the human temporal cortex using samples obtained from brain surgery. We analyzed multineuron patch-clamp recordings in layer 2-3 pyramidal neurons and identified substantial differences compared with rodents. Reciprocity showed random distribution, synaptic strength was independent from connection probability, and connectivity of the supragranular temporal cortex followed a directed and mostly acyclic graph topology. Application of these principles in neuronal models increased dimensionality of network dynamics, suggesting a critical role for cortical computation.