6693期

最新文章

• Generalized biomolecular modeling and design with RoseTTAFold All-Atom AI翻译
  作者：Krishna, Rohith; Wang, Jue; Ahern, Woody; Sturmfels, Pascal; Venkatesh, Preetham; Kalvet, Indrek; Lee, Gyu Rie; Morey-Burrows, Felix S.; Anishchenko, Ivan; Humphreys, Ian R.; Mchugh, Ryan; Vafeados, Dionne; Li, Xinting; Sutherland, George A.; Hitchcock, Andrew; Hunter, C. Neil; Kang, Alex; Brackenbrough, Evans; Bera, Asim K.; Baek, Minkyung; Dimaio, Frank; Baker, David
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Sheffield; Seoul National University (SNU)
  摘要：Deep-learning methods have revolutionized protein structure prediction and design but are presently limited to protein-only systems. We describe RoseTTAFold All-Atom (RFAA), which combines a residue-based representation of amino acids and DNA bases with an atomic representation of all other groups to model assemblies that contain proteins, nucleic acids, small molecules, metals, and covalent modifications, given their sequences and chemical structures. By fine-tuning on denoising tasks, we dev...
• Imagining other worlds AI翻译
  作者：Tasker, Elizabeth
  作者单位：Japan Aerospace Exploration Agency (JAXA); Institute of Space & Astronautical Science (ISAS)
  摘要：An astronomer offers a vivid portrait of exoplanet landscapes
• Exposing belowground plant communication AI翻译
  作者：Guerrieri, Emilio; Rasmann, Sergio
  作者单位：Consiglio Nazionale delle Ricerche (CNR); Istituto per la Protezione Sostenibile delle Piante (IPSP-CNR); University of Neuchatel
  摘要：Root exudation could be harnessed for ecological and applied research
• A national-scale assessment of land subsidence in China's major cities AI翻译
  作者：Ao, Zurui; Hu, Xiaomei; Tao, Shengli; Hu, Xie; Wang, Guoquan; Li, Mingjia; Wang, Fang; Hu, Litang; Liang, Xiuyu; Xiao, Jingfeng; Yusup, Asadilla; Qi, Wenhua; Ran, Qinwei; Fang, Jiayi; Chang, Jinfeng; Zeng, Zhenzhong; Fu, Yongshuo; Xue, Baolin; Wang, Ping; Zhao, Kefei; Li, Le; Li, Wenkai; Li, Yumei; Jiang, Mi; Yang, Yuanhe; Shen, Haihua; Zhao, Xia; Shi, Yue; Wu, Bo; Yan, Zhengbing; Wang, Mengjia; Su, Yanjun; Hu, Tianyu; Ma, Qin; Bai, Hao; Wang, Lijun; Yang, Ziyan; Feng, Yuhao; Zhang, Danhua; Huang, Erhan; Pan, Jiamin; Ye, Huiying; Yang, Chen; Qin, Yanwei; He, Chenqi; Guo, Yanpei; Cheng, Kai; Ren, Yu; Yang, Haitao; Zheng, Chengyang; Zhu, Jiangling; Wang, Shaopeng; Ji, Chengjun; Zhu, Biao; Liu, Hongyan; Tang, Zhiyao; Wang, Zhiheng; Zhao, Shuqing; Tang, Yanhong; Xing, Hanfa; Guo, Qinghua; Liu, Yu; Fang, Jingyun
  作者单位：South China Normal University; Peking University; Peking University; Peking University; University of Houston System; University of Houston; Southern University of Science & Technology; Peking University; Beijing Normal University; Southern University of Science & Technology; University System Of New Hampshire; University of New Hampshire; Hangzhou Normal University; Zhejiang University; Beijing Normal University; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Guangdong University of Technology; Sun Yat Sen University; Chinese Academy of Sciences; Institute of Zoology, CAS; Sun Yat Sen University; Chinese Academy of Sciences; Institute of Botany, CAS; Zhengzhou University; Nanjing Normal University; Nanjing Normal University; Nanjing Normal University; Southwest Jiaotong University; Beijing Forestry University; Peking University; Hainan University
  摘要：China's massive wave of urbanization may be threatened by land subsidence. Using a spaceborne synthetic aperture radar interferometry technique, we provided a systematic assessment of land subsidence in all of China's major cities from 2015 to 2022. Of the examined urban lands, 45% are subsiding faster than 3 millimeters per year, and 16% are subsiding faster than 10 millimeters per year, affecting 29 and 7% of the urban population, respectively. The subsidence appears to be associated with a ...
• Mars sample return faces redo AI翻译
  作者：Brainard, Jeffrey
• Phage predation, disease severity, and pathogen genetic diversity in cholera patients AI翻译
  作者：Madi, Naima; Cato, Emilee T.; Abu Sayeed, Md.; Creasy-Marrazzo, Ashton; Cuenod, Aline; Islam, Kamrul; Khabir, Md. Imam Ul; Bhuiyan, Md. Taufiqur R.; Begum, Yasmin A.; Freeman, Emma; Vustepalli, Anirudh; Brinkley, Lindsey; Kamat, Manasi; Bailey, Laura S.; Basso, Kari B.; Qadri, Firdausi; Khan, Ashraful I.; Shapiro, B. Jesse; Nelson, Eric J.
  作者单位：McGill University; McGill University; State University System of Florida; University of Florida; State University System of Florida; University of Florida; International Centre for Diarrhoeal Disease Research (ICDDR); International Centre for Diarrhoeal Disease Research (ICDDR); State University System of Florida; University of Florida; McGill University
  摘要：Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage)-bacterial interactions, we lack an understanding of how these interactions evolve and impact disease within patients. In this work, we report a year-long, nationwide study of diarrheal disease patients in Bangladesh. Among cholera patients, we quantified Vibrio cholerae (prey) and its virulent phages (predators) using metagenomics and quantitative polymerase chain reaction while accounting for antibio...
• Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need AI翻译
  作者：Tan, Bowen; Browne, Caleb J.; Nobauer, Tobias; Vaziri, Alipasha; Friedman, Jeffrey M.; Nestler, Eric J.
  作者单位：Howard Hughes Medical Institute; Rockefeller University; Icahn School of Medicine at Mount Sinai; University of Toronto; Centre for Addiction & Mental Health - Canada; Rockefeller University; Rockefeller University
  摘要：Drugs of abuse are thought to promote addiction in part by hijacking brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we found that drugs of abuse augment dopaminoceptive ensemble activity in the nucleus accumbens (NAc) and disorganize overlapping ensemble responses to natural rewards in a cell type-specific manner. Combining FOS-Seq, CRISPR-perturbation, and single-nucleus RNA sequencing, we identifi...
• Global plastics treaty needs trusted science AI翻译
  作者：Farrelly, Trisia; Gammage, Tom; Almroth, Bethanie Carney; Thompson, Richard
  作者单位：Massey University; James Cook University; University of Gothenburg; University of Plymouth
• Hiring ban disrupts research at Florida universities AI翻译
  作者：Mervis, Jeffrey
  摘要：Suit seeks to overturn state law targeting graduate and postdocs from China and other countries of concern
• Blinding reviewers reduces skew AI翻译
  作者：Brainard, Jeffrey