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作者：Service, Robert F.
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作者：Feuerborn, T. R.; Appelt, M.; Bougiouri, K.; Bachmann, L.; Nielsen, I. Broman; Buckley, R. M.; Egevang, C.; Diaz-Maroto, P. Fernandez; Gopalakrishnan, S.; Gotfredsen, A. B.; Gregersen, K. M.; Gronnow, B.; Jensen, M. Lund; Madsen, C. K.; Markussen, U.; Midtdal, A.; Schmidt, A. L.; Armero, A. Serres; Vitale, E.; Wiig, O.; Zhang, G.; Dalen, L.; Frantz, L. A. F.; Gilbert, M. T. P.; Meldgaard, M.; Ostrander, E. A.; Sinding, M. -h. s.; Hansen, A. J.
作者单位：National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Copenhagen; University of Copenhagen; Swedish Museum of Natural History; University of Copenhagen; University of Oslo; Zhejiang University; University of Copenhagen; Swedish Museum of Natural History; Stockholm University; University of Munich; University of Copenhagen
摘要：The Qimmeq (Greenland sled dog) has worked continuously with the Inuit in Greenland for more than 800 years. However, they now face drastic population declines caused by climate change, urbanization, and competition from snowmobiles. This study sequenced 92 modern and ancient genomes to investigate how centuries of isolation shaped the regional Qimmeq populations and the impact of European contact. We found distinct regional populations and evidence for two migrations of dogs into Greenland wi...
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作者：Fisher, Lee
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
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作者：Lin, Hsiu-Chuan; Janssens, Jasper; Eisinger, Benedikt; Hornauer, Philipp; Kroell, Ann-Sophie; Santel, Malgorzata; Pascual-Garcia, Maria; Okamoto, Ryoko; Karava, Kyriaki; He, Zhisong; Priouret, Marthe; Schroeter, Manuel; Camp, J. Gray; Treutlein, Barbara
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Roche Holding; University of Basel
摘要：Human neurons programmed through transcription factor (TF) overexpression model neuronal differentiation and disease. However, the diversity of neuronal subtypes programmable in vitro remains unresolved. We modulated developmental signaling pathways combined with TF overexpression to explore the spectrum of neuron subtypes generated from pluripotent stem cells. We screened 480 morphogen signaling modulations coupled with TF induction using a multiplexed single-cell transcriptomic readout. Anal...
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作者：Greshko, Michael
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作者：Hoagland, Daisy A.; Rodriguez-Morales, Patricia; Mann, Alexander O.; Baez Vazquez, Alan Y.; Yu, Shuang; Lai, Alicia; Kane, Harry; Dang, Susanna M.; Lin, Yunkang; Thorens, Louison; Begum, Shahinoor; Castro, Martha A.; Pope, Scott D.; Lim, Jaechul; Li, Shun; Zhang, Xian; Li, Ming O.; Kim, Carla F.; Jackson, Ruaidhri; Medzhitov, Ruslan; Franklin, Ruth A.
作者单位：Harvard University; Harvard University; Harvard Medical School; Yale University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Northeastern University; Memorial Sloan Kettering Cancer Center; Harvard University; Howard Hughes Medical Institute; Yale University
摘要：Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the pathological effects of type I interferon (IFN-I) during infection and damage in mice. At baseline, OSM-deficient mice exhibited altered alveolar type II (ATII) epithelial cell states. In response to influenza or viral mimic challenge, mice lacking OSM exhibited heightened IFN-I responses and increased...
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作者：Charette, Andre B.
作者单位：Universite de Montreal
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作者：Giles, Cynthia; Coglianese, Cary
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
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作者：Du, Siling; Kipnis, Jonathan
作者单位：Washington University (WUSTL); Washington University (WUSTL)
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作者：Keil, Samantha A.; Jansson, Deidre; Braun, Molly; Iliff, Jeffrey J.
作者单位：University of Washington; University of Washington Seattle; US Department of Veterans Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound Health Care System; Cornell University; Weill Cornell Medicine; University System of Georgia; Augusta University; University of Washington; University of Washington Seattle
摘要：Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer's disease (AD). Our understanding of glymphatic function and its involvement in the pathogenesis of AD derives primarily from correlative clinical data and rodent studies. A causal role for glymphatic dysfunction in AD has not yet been established in humans. We review current approaches to assess glymphatic function clinically, which capture different f...
