6756期

最新文章

• Microglia replacement halts the progression of microgliopathy in mice and humans AI翻译
  作者：Wu, Jingying; Wang, Yafei; Li, Xiaoyu; Ouyang, Pei; Cai, Yuanyuan; He, Yang; Zhang, Mengyuan; Luan, Xinghua; Jin, Yuxiao; Wang, Jie; Xiao, Yujie; Liang, Yuqing; Xie, Fang; Shu, Yousheng; Hu, Jiong; Chang, Chunkang; Jiang, Jieling; Wu, Dong; Zhao, Youshan; Liu, Taohui; Li, Yuxin; Huang, Xiaojun; Li, Yao; Zhang, Junfang; Cao, Yuwen; Cheng, Xin; Mao, Ying; Rao, Yanxia; Cao, Li; Peng, Bo
  作者单位：Shanghai Jiao Tong University; Fudan University; Fudan University; Fudan University; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan University
  摘要：Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and a fatal neurological disease without clinical cure. We developed mouse models harboring human hotspot mutations of CAMP and replaced CSF1R-deficient microglia with CSF1R-normal cells through microglia replacement by bone marrow transplantation ...
• Organelles share the load AI翻译
  作者：Fransen, Marc
  作者单位：KU Leuven
• AI challenge to find lost Amazonian cities draws critics AI翻译
  作者：Moutinho, Sofia
• Cryo-EM structure of human telomerase dimer reveals H/ACA RNP-mediated dimerization AI翻译
  作者：Balch, Sebastian; Sekne, Zala; Franco-Echevarria, Elsa; Ludzia, Patryk; Kretsch, Rachael C.; Sun, Wenqing; Yu, Haopeng; Ghanim, George E.; Thorkelsson, Sigurdur; Ding, Yiliang; Das, Rhiju; Nguyen, Thi Hoang Duong
  作者单位：MRC Laboratory Molecular Biology; Stanford University; Northeast Normal University - China; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Centre; Stanford University; Stanford Medicine; Stanford University; Howard Hughes Medical Institute; Stanford Medicine; University of Cambridge; Princeton University; Thermo Fisher Scientific
  摘要：Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showed that human telomerase is typically monomeric, containing a single copy of TERT and hTR. Evidence for dimeric complexes exists, although the composition, high-resolution structure, and function remain elusive. Here, we report the cryo-electron microscopy (cryo-EM) structure of a human telomerase ...
• Should grant applicants judge competitors' proposals? AI翻译
  作者：Brainard, Jeffrey
• Single- and multithread rivers originate from (im)balance between lateral erosion and accretion AI翻译
  作者：Chadwick, Austin J.; Greenberg, Evan; Ganti, Vamsi
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Columbia University; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL)
  摘要：Why river channels confine flow to a single pathway or divide flow into multiple interwoven pathways (threads) forms a long-standing fundamental question in river science, which to date remains poorly understood. In this study, we probed channel-pattern origins by mapping thread dynamics along 84 rivers from 36 years of global satellite imagery using particle image velocimetry. Results show that single-thread channels originate from a balance between lateral erosion and accretion, which enable...
• The forearc seismic belt: A fluid pathway constraining down-dip megathrust earthquake rupture AI翻译
  作者：Suzuki, Rintaroh; Uchida, Naoki; Zhu, Weiqiang; Beroza, Gregory C.; Nakayama, Takashi; Yoshida, Keisuke; Toyokuni, Genti; Takagi, Ryota; Azuma, Ryosuke; Hasegawa, Akira
  作者单位：Tohoku University; University of Tokyo; University of California System; University of California Berkeley; Stanford University
  摘要：A portion of fluids subducted in an oceanic plate is thought to return to Earth's surface and has the potential to influence faulting during that migration. We used machine learning to detect and locate earthquakes in the northeast Japan forearc using data from a cabled ocean-bottom seismic network. That seismicity shows vertical distributions extending from the subducted plate to near the sea floor. The forearc seismic belt corresponds to the seismicity assumed to result from fluid supply fro...
• China's antismog push faces challenges AI翻译
  作者：Qiang, Yi; Cao, Qiang; Xia, Liangjing; Chen, Yuquan; Wu, Xinyan; Chi, Hao
  作者单位：Kunming University of Science & Technology; Hong Kong Baptist University; Monash University; Southwest Medical University
• Integrated prostheses restore dynamic movement AI翻译
  作者：Fisher, Lee
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
• Human neuron subtype programming via single-cell transcriptome-coupled patterning screens AI翻译
  作者：Lin, Hsiu-Chuan; Janssens, Jasper; Eisinger, Benedikt; Hornauer, Philipp; Kroell, Ann-Sophie; Santel, Malgorzata; Pascual-Garcia, Maria; Okamoto, Ryoko; Karava, Kyriaki; He, Zhisong; Priouret, Marthe; Schroeter, Manuel; Camp, J. Gray; Treutlein, Barbara
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Roche Holding; University of Basel
  摘要：Human neurons programmed through transcription factor (TF) overexpression model neuronal differentiation and disease. However, the diversity of neuronal subtypes programmable in vitro remains unresolved. We modulated developmental signaling pathways combined with TF overexpression to explore the spectrum of neuron subtypes generated from pluripotent stem cells. We screened 480 morphogen signaling modulations coupled with TF induction using a multiplexed single-cell transcriptomic readout. Anal...