6756期

最新文章

• PEPFAR disruptions could cause HIV resurgence AI翻译
  作者：Powers, Kimberly A.; Lessler, Justin; Cole, Stephen R.; Cohen, Myron S.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
• Overturning circulation structures the microbial functional seascape of the South Pacific AI翻译
  作者：Kolody, Bethany C.; Sachdeva, Rohan; Zheng, Hong; Fuessy, Zoltan; Tsang, Eunice; Sonnerup, Rolf E.; Purkey, Sarah G.; Allen, Eric E.; Banfield, Jillian F.; Allen, Andrew E.
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; J. Craig Venter Institute; University of California System; University of California Berkeley; University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Monash University
  摘要：Global overturning circulation partitions the deep ocean into regions, each with different physicochemical characteristics, but the extent to which these water masses represent distinct ecosystems remains unknown. In this work, we integrate extensive genomic information with hydrography and water mass age to delineate microbial taxonomic and functional boundaries across the South Pacific. Prokaryotic richness steeply increases with depth in the surface ocean, which forms a so-called phylocline...
• The boundless energy, and ego, of Luis Alvarez AI翻译
  作者：Bhattacharya, Ananyo
• Atomic explosion AI翻译
  作者：Cho, Adrian
• Tissue-integrated bionic knee restores versatile legged movement after amputation AI翻译
  作者：Shu, Tony; Levine, Daniel; Yeon, Seong Ho; Chun, Ethan; Shallal, Christopher C.; McCullough, John; Branemark, Rickard; Carty, Matthew J.; Ferrone, Marco; Boerhout, Sean; Ko, Alexander; Sullivan, Corey L.; Zhu, Gloria; Nawrot, Michael; Carney, Matthew; Wieschhoff, Ged; Friedman, Gabriel; Herr, Hugh
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Gothenburg; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Lower-extremity prostheses have evolved through mechanical redesigns that prioritize improved cyclic locomotion. However, this limited approach to limb restoration has precluded necessary progress toward recovering the versatile acyclic movements that constitute the remainder of human athleticism. We present an osseointegrated mechanoneural prosthesis that incorporates modified hard and soft tissues along with permanently implanted hardware in a neuroembodied design. We developed a biomimetic ...
• Discrete spatiotemporal encoding of striatal dopamine transmission AI翻译
  作者：Yee, Andrew G.; Liao, Yini; Muntean, Brian S.; Ford, Christopher P.
  作者单位：University of Colorado System; University of Colorado Anschutz; University System of Georgia; Augusta University
  摘要：Dopamine (DA) transmission critically regulates diverse, basal ganglia-dependent behaviors by activating distinct subtypes of G protein-coupled receptors. Spatially broad DA release has been extensively characterized, but how DA transmission affects striatal function at a subcellular scale remains poorly understood. Using 2P imaging and whole-cell electrophysiology, we defined the spatiotemporal properties of DA transmission onto striatal indirect pathway spiny projection neurons. Sparse activ...
• A single theory for the evolution of sex chromosomes and the two rules of speciation AI翻译
  作者：Lenormand, Thomas; Roze, Denis
  作者单位：Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Sorbonne Universite
  摘要：Sex chromosomes are involved in three major empirical patterns: (i) Y (or W) chromosomes are often nonrecombining and degenerate; (ii) heterogametic offspring (XY or ZW) from interspecific crosses are more often sterile or inviable compared with homogametic offspring (Haldane's rule); and (iii) the X (or Z) has a disproportionately large effect on reproductive isolation between species compared with autosomes (the large X effect). Each observation has received its own tailored explanation invo...
• Compartmentalization reduces conflict in multipartner plant-insect symbioses AI翻译
  作者：Chomicki, Guillaume; Metzler, Dirk; Naikatini, Alivereti; Renner, Susanne S.
  作者单位：Durham University; University of Munich; University of the South Pacific; Washington University (WUSTL)
  摘要：Many symbioses involve one host species having several mutualist partners, yet theory predicts that unrelated symbionts lead to destabilizing conflict through competition for host resources. We combined isotope labeling, computed-tomography three-dimensional models, behavioral field experiments, and mathematical models to show that Squamellaria plant hosts reduce conflict among their multiple ant symbiont species by offering nesting sites (domatia) divided into compartments with separate entra...
• ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox AI翻译
  作者：DiGiovanni, Laura F.; Khroud, Prabhsimran K.; Carmichael, Ruth E.; Schrader, Tina A.; Gill, Shivneet K.; Germain, Kyla; Jomphe, Robert Y.; Wiesinger, Christoph; Boutry, Maxime; Kamoshita, Maki; Snider, Daniel; Stubbings, Garret; Hua, Rong; Garber, Noel; Hacker, Christian; Rutenberg, Andrew D.; Melnyk, Roman A.; Berger, Johannes; Schrader, Michael; Raught, Brian; Kim, Peter K.
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Exeter; University of Toronto; Hospital for Sick Children (SickKids); Medical University of Vienna; University of Osaka; Dalhousie University; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; Kyung Hee University
  摘要：Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmitochondrial antioxidant mechanisms is less well understood. We found a direct role for peroxisomes in maintaining mitochondrial redox homeostasis through contact-mediated reactive oxygen species (ROS) transfer. We found that ACBD5 and PTPIP51 form a contact between peroxisomes and mitochondria. The ...