6765期

最新文章

• Include scorpions in global conservation plans AI翻译
  作者：Blasco-Arostegui, Javier; Moreno-Gonzalez, Jairo A.; Loria, Stephanie F.; Carvalho, Leonardo S.; Bird, Tharina L.; Nguyen, Ahn D.; Barahoei, Hossein; Haddad, Charles R.; Prendini, Lorenzo
  作者单位：Universidade de Lisboa; American Museum of Natural History (AMNH); American Museum of Natural History (AMNH); University of Central Oklahoma; Universidade Federal do Piaui; University of Pretoria; Vietnam Academy of Science & Technology (VAST); University of the Free State
• Florida plan to nix vaccine mandates raises alarm AI翻译
  作者：Cohen, Jon
• Harvard court victory leaves scientists feeling vindicated but uncertain AI翻译
  作者：Jacobs, Phie
• Did Great Britain's economy shrug off the end of Roman rule? AI翻译
  作者：Gibbons, Ann
• An ELSI for AI: Learning from genetics to govern algorithms AI翻译
  作者：Nelson, Alondra
  作者单位：Institute for Advanced Study - USA
• Burning questions on wildfire AI翻译
  作者：Qian, Yun
  作者单位：United States Department of Energy (DOE); Pacific Northwest National Laboratory
• New picture of Mars's interior emerges from lander data Studies identify a solid inner core and buried remnants of giant impacts PAUL VOOSEN AI翻译
  作者：Voosen, Paul
• Cries into ties AI翻译
  作者：Bellone, Camilla
  作者单位：University of Geneva
• Structural basis for LZTR1 recognition of RAS GTPases for degradation AI翻译
  作者：Dharmaiah, Srisathiyanarayanan; Bonsor, Daniel A.; Mo, Stephanie P.; Fernandez-Cabrera, Alvaro; Chan, Albert H.; Messing, Simon; Drew, Matthew; Vega, Martha; Nissley, Dwight V.; Esposito, Dominic; Castel, Pau; Simanshu, Dhirendra K.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
  摘要：The RAS family of small guanosine triphosphatases (GTPases) are tightly regulated signaling molecules that are further modulated by ubiquitination and proteolysis. Leucine Zipper-like Transcription Regulator 1 (LZTR1), a substrate adapter of the Cullin-3 RING E3 ubiquitin ligase, binds specific RAS GTPases and promotes their ubiquitination and proteasomal degradation. We present structures of LZTR1 Kelch domains bound to RIT1, MRAS, and KRAS, revealing interfaces that govern RAS isoform select...
• Noncanonical circuits, states, and computations of the hippocampus AI翻译
  作者：Farrell, Jordan S.; Soltesz, Ivan
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Stanford University; Stanford Medicine; Stanford University
  摘要：Traditional views of hippocampal function are largely based on the canonical flow of information from the entorhinal cortex through the trisynaptic loop-comprising the dentate gyrus and cornu ammonis regions CA3 and CA1-and back to cortex, where the hippocampus plays an important role in transforming relevant information into a usable storage system. This classic circuit has inspired current thinking on hippocampal functions related to learning, memory, and spatial navigation, but the potentia...