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作者:Zelmanoff, Daniel D.; Bornstein, Rebecca; Kaufman, Menachem; Dine, Julien; Wietek, Jonas; Litvin, Anna; Abraham, Shaked; Cohen, Savanna; Atzmon, Ayelet; Porat, Ido; Yizhar, Ofer
作者单位:Weizmann Institute of Science; Weizmann Institute of Science; Boehringer Ingelheim; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin
摘要:Oxytocin is essential in shaping social behavior across the lifespan. Although the role of oxytocin signaling in parental care has been widely investigated, little is known about its function in social behavior during early life. We studied the role of oxytocin in mouse pup social behavior during acute separation from the mother as well as upon reunion. The activity of oxytocin neurons was increased by acute maternal separation. Behaviorally, maternally separated pups emitted more ultrasonic v...
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作者:Dietz, Maximilian; Protchenko, Andrey V.; Crumpton, Agamemnon E.; Karwasara, Surendar; Roy, Matthew M. D.; Stewart-Moreno, James; Timmel, Christiane; Aldridge, Simon
作者单位:University of Oxford
摘要:In contrast to transition elements, s- and p-block metal compounds that coordinate carbon monoxide (CO) under near-ambient conditions are elusive. Here, we report an isolable, crystalline main-group metal carbonyl complex and its isomerization to a carbene-stabilized metal atom. The stannylene (Boryl)2Sn [where Boryl is B(NDippCH)2] coordinates CO reversibly, affording an isolable adduct below 0 degrees C, which was characterized by x-ray crystallography. This complex rearranges at temperature...
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作者:Li, An; Zhou, Wenjianlong; Li, Huizeng; Fang, Wei; Luo, Yifei; Li, Zheng; Zhang, Qingrong; Liu, Quan; Xu, Qin; Xue, Luanluan; Li, Kaixuan; Yuan, Renxuan; Liu, Wanling; Jia, Wang; Chen, Xiaodong; Song, Yanlin
作者单位:Chinese Academy of Sciences; Institute of Chemistry, CAS; Capital Medical University; Tianjin University; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Materials Research & Engineering (IMRE); Army Medical University; Army Medical University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanyang Technological University
摘要:Bioelectronic interfaces demonstrate promising applications in health monitoring, medical treatment, and augmented reality. However, conformally wrapping these film devices onto three-dimensional surfaces often leads to stress-induced damage. We propose a drop-printing strategy that enables damage-free film transfer using a droplet. The droplet acts as a lubricating layer between the film and the target surface, facilitating local sliding during shape-adaptive deformation. This mechanism preve...
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作者:Zou, Yibiao; Crowther, Thomas W.; Smith, Gabriel Reuben; Ma, Haozhi; Mo, Lidong; Bialic-Murphy, Lalasia; Potapov, Peter; Gawecka, Klementyna A.; Xu, Chi; Negret, Pablo J.; Lauber, Thomas; Wu, Zhaofei; Rebindaine, Dominic; Zohner, Constantin M.
作者单位:Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Nankai University; University System of Maryland; University of Maryland College Park; University of Zurich; UK Centre for Ecology & Hydrology (UKCEH); Nanjing University; University of Bern; Western Sydney University; Beijing Normal University
摘要:Habitat fragmentation, in which contiguous forests are broken into smaller, isolated patches, threatens biodiversity by disrupting species movement, shrinking populations, and altering ecosystem dynamics. Past assessments suggested declining global fragmentation, but they relied on structure-based metrics that overlook ecological connectivity. We analyzed global forest fragmentation from 2000 to 2020 using complementary metrics that captured patch connectivity, aggregation, and structure. Conn...
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作者:Dietrich, Melanie H.; Chmielewski, Jill; Chan, Li-Jin; Tan, Li Lynn; Adair, Amy; Lyons, Frankie M. T.; Gabriela, Mikha; Lopaticki, Sash; Dite, Toby A.; Dagley, Laura F.; Pazzagli, Lucia; Gupta, Priya; Kamil, Mohd; Vaughan, Ashley M.; Rojrung, Rattanaporn; Abraham, Anju; Mazhari, Ramin; Longley, Rhea J.; Zeglinski, Kathleen; Gouil, Quentin; Mueller, Ivo; Fabb, Stewart A.; Shandre-Mugan, Rekha; Pouton, Colin W.; Glukhova, Alisa; Shakeel, Shabih; Tham, Wai-Hong
作者单位:Walter & Eliza Hall Institute; University of Melbourne; University of Melbourne; Peter Doherty Institute; Seattle Children's Hospital; University of Washington; University of Washington Seattle; Ehime University; Mahidol University; La Trobe University; Olivia Newton-John Cancer Research Institute; La Trobe University; Shanghai Jiao Tong University; Monash University; University of Melbourne; Monash University; Monash University; Australian National University
摘要:Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/45 proteins are critical for male fertility and transmission of the malaria parasite. They form a core fertilization complex, but it is unknown how they interact. We determined a cryo-electron microscopy structure of the endogenous Pfs230-Pfs48/45 complex showing that Pfs48/45 interacts with Pfs23...
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作者:Ma, Qihan; Wei, Linyi; Wang, Yong; Zhang, Guang J.; Zhou, Xinlin; Wang, Bin
作者单位:Fudan University; Tsinghua University; Chinese Academy of Sciences; Institute of Earth Environment, CAS; University of California System; University of California San Diego; Scripps Institution of Oceanography; Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要:Conventional wisdom suggests that wildfires in the western United States (WUS) degrade air quality nationwide as a result of aerosol emissions and eastward transport. However, we found that heat produced by wildfires, a commonly neglected effect, can reduce fine particle concentrations (PM2.5) in the eastern United States (EUS) by an amount comparable to the increases in the WUS during the fire season. This phenomenon arises from fire heat-induced convection in the WUS and subsequent downstrea...