8009期

最新文章

• How volcanoes shaped our planet - and why we need to be ready for the next big eruption AI翻译
  作者：Handley, Heather
  作者单位：University of Twente
  摘要：The world should learn from past disasters and prepare for the effects of future, inevitable volcanic catastrophes, a wide-reaching book teaches us. The world should learn from past disasters and prepare for the effects of future, inevitable volcanic catastrophes, a wide-reaching book teaches us.
• Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia AI翻译
  作者：Koeberl, Dwight; Schulze, Andreas; Sondheimer, Neal; Lipshutz, Gerald S.; Geberhiwot, Tarekegn; Li, Lerong; Saini, Rajnish; Luo, Junxiang; Sikirica, Vanja; Jin, Ling; Liang, Min; Leuchars, Mary; Grunewald, Stephanie
  作者单位：Duke University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of California System; University of California Los Angeles; University of Birmingham; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of London; University College London
  摘要：Propionic acidaemia is a rare disorder caused by defects in the propionyl-coenzyme A carboxylase alpha or beta (PCCA or PCCB) subunits that leads to an accumulation of toxic metabolites and to recurrent, life-threatening metabolic decompensation events. Here we report interim analyses of a first-in-human, phase 1/2, open-label, dose-optimization study and an extension study evaluating the safety and efficacy of mRNA-3927, a dual mRNA therapy encoding PCCA and PCCB. As of 31 May 2023, 16 partic...
• Targeting RNA opens therapeutic avenues for Timothy syndrome AI翻译
  作者：Velasco, Silvia
  作者单位：Murdoch Children's Research Institute
  摘要：A therapeutic strategy that alters gene expression in a rare and severe neurodevelopmental condition has been tested in stem-cell-based models of the disease, and has been shown to correct genetic and cellular defects.
• Nature exhibits scientist portraits AI翻译
  作者：Leeming, Jack
• Macromolecular condensation buffers intracellular water potential (vol 623, pg 842, 2023) AI翻译
  作者：Watson, Joseph L.; Seinkmane, Estere; Styles, Christine T.; Mihut, Andrei; Kruger, Lara K.; McNally, Kerrie E.; Planelles-Herrero, Vicente Jose; Dudek, Michal; McCall, Patrick M.; Barbiero, Silvia; Oever, Michael Vanden; Peak-Chew, Sew Yeu; Porebski, Benjamin T.; Zeng, Aiwei; Rzechorzek, Nina M.; Wong, David C. S.; Beale, Andrew D.; Stangherlin, Alessandra; Riggi, Margot; Iwasa, Janet; Morf, Jorg; Miliotis, Christos; Guna, Alina; Inglis, Alison J.; Brugues, Jan; Voorhees, Rebecca M.; Chambers, Joseph E.; Meng, Qing-Jun; O'Neill, John S.; Edgar, Rachel S.; Derivery, Emmanuel
• Robust optical clocks promise stable timing in a portable package AI翻译
  作者：Marlow, Bonnie L. S.; Hirschauer, Jonathan
  作者单位：MITRE Corporation
  摘要：A highly precise timekeeping instrument has been adapted for the real world. The compact and robust device is smaller than its commercial counterparts and performs comparably in the laboratory and aboard a naval ship.
• The Middle East's largest hypersaline lake risks turning into an environmental disaster zone AI翻译
  作者：Mohammadi, Alireza; Azareh, Ali; Khanjani, Mohammad Hossein; Sharifinia, Moslem
  摘要：Letter to the Editor
• A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure AI翻译
  作者：Benevento, Marco; Alpar, Alan; Gundacker, Anna; Afjehi, Leila; Balueva, Kira; Hevesi, Zsofia; Hanics, Janos; Rehman, Sabah; Pollak, Daniela D.; Lubec, Gert; Wulff, Peer; Prevot, Vincent; Horvath, Tamas L.; Harkany, Tibor
  作者单位：Medical University of Vienna; Semmelweis University; Semmelweis University; Medical University of Vienna; Paracelsus Private Medical University; University of Kiel; Universite de Lille; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Lille; Yale University
  摘要：Empirical evidence suggests that heat exposure reduces food intake. However, the neurocircuit architecture and the signalling mechanisms that form an associative interface between sensory and metabolic modalities remain unknown, despite primary thermoceptive neurons in the pontine parabrachial nucleus becoming well characterized(1). Tanycytes are a specialized cell type along the wall of the third ventricle(2) that bidirectionally transport hormones and signalling molecules between the brain's...
• PHYSICISTS CLOSE IN ON UNIVERSE-EXPANSION MYSTERY AI翻译
  作者：Castelvecchi, Davide
• Machine learning reveals the control mechanics of an insect wing hinge AI翻译
  作者：Melis, Johan M.; Siwanowicz, Igor; Dickinson, Michael H.
  作者单位：California Institute of Technology; Howard Hughes Medical Institute
  摘要：Insects constitute the most species-rich radiation of metazoa, a success that is due to the evolution of active flight. Unlike pterosaurs, birds and bats, the wings of insects did not evolve from legs1, but are novel structures that are attached to the body via a biomechanically complex hinge that transforms tiny, high-frequency oscillations of specialized power muscles into the sweeping back-and-forth motion of the wings2. The hinge consists of a system of tiny, hardened structures called scl...