8009期

最新文章

• Valleytronics in bulk MoS2 with a topologic optical field AI翻译
  作者：[Anonymous]
  摘要：The valley degree of freedom(1-4) of electrons in materials promises routes towards energy-efficient information storage with enticing prospects for quantum information processing(5-7). Current challenges in utilizing valley polarization are symmetry conditions that require monolayer structures(8,9) or specific material engineering(10-13), non-resonant optical control to avoid energy dissipation and the ability to switch valley polarization at optical speed. We demonstrate all-optical and non-...
• Any plan to make smoking obsolete is the right step AI翻译
  作者：[Anonymous]
  摘要：The United Kingdom is correct to attempt to end the single largest preventable cause of illness and death, as was New Zealand before its government changed its mind.
• Taiwan earthquake's devastating impacts AI翻译
  作者：Fung, Fun Man; Liu, Yi-Hsin
  作者单位：National University of Singapore; National Taiwan Normal University
• Retractions are part of science - misconduct isnt AI翻译
  作者：[Anonymous]
• Ecologists: don't lose touch with the joy of fieldwork AI翻译
  作者：Mantegna, Chris
  作者单位：University of Washington; University of Washington Seattle
  摘要：Amid the data deluge provided by lab-based techniques, such as environmental-DNA analysis, true connection still comes only in the outdoors.
• Emergence of fractal geometries in the evolution of a metabolic enzyme AI翻译
  作者：Sendker, Franziska L.; Lo, Yat Kei; Heimerl, Thomas; Bohn, Stefan; Persson, Louise J.; Mais, Christopher-Nils; Sadowska, Wiktoria; Paczia, Nicole; Nussbaum, Eva; Olmos, Maria del Carmen Sanchez; Forchhammer, Karl; Schindler, Daniel; Erb, Tobias J.; Benesch, Justin L. P.; Marklund, Erik G.; Bange, Gert; Schuller, Jan M.; Hochberg, Georg K. A.
  作者单位：Max Planck Society; Philipps University Marburg; Uppsala University; Philipps University Marburg; University of Oxford; Max Planck Society; Eberhard Karls University of Tubingen; Max Planck Society; Philipps University Marburg; Max Planck Society
  摘要：Fractals are patterns that are self-similar across multiple length-scales(1). Macroscopic fractals are common in nature(2-4); however, so far, molecular assembly into fractals is restricted to synthetic systems(5-12). Here we report the discovery of a natural protein, citrate synthase from the cyanobacterium Synechococcus elongatus, which self-assembles into Sierpinski triangles. Using cryo-electron microscopy, we reveal how the fractal assembles from a hexameric building block. Although diffe...
• NEW BENCHMARKS NEEDED TO KEEP PACE WITH AI'S ADVANCE AI翻译
  作者：Jones, Nicola
• Proteome-scale discovery of protein degradation and stabilization effectors AI翻译
  作者：Poirson, Juline; Cho, Hanna; Dhillon, Akashdeep; Haider, Shahan; Imrit, Ahmad Zoheyr; Lam, Mandy Hiu Yi; Alerasool, Nader; Lacoste, Jessica; Mizan, Lamisa; Wong, Cassandra; Gingras, Anne-Claude; Schramek, Daniel; Taipale, Mikko
  作者单位：University of Toronto; University of Toronto; University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute
  摘要：Targeted protein degradation and stabilization are promising therapeutic modalities because of their potency, versatility and their potential to expand the druggable target space(1,2). However, only a few of the hundreds of E3 ligases and deubiquitinases in the human proteome have been harnessed for this purpose, which substantially limits the potential of the approach. Moreover, there may be other protein classes that could be exploited for protein stabilization or degradation(3-5), but there...
• Necroptosis blockade prevents lung injury in severe influenza AI翻译
  作者：Gautam, Avishekh; Boyd, David F.; Nikhar, Sameer; Zhang, Ting; Siokas, Ioannis; Van de Velde, Lee-Ann; Gaevert, Jessica; Meliopoulos, Victoria; Thapa, Bikash; Rodriguez, Diego A.; Cai, Kathy Q.; Yin, Chaoran; Schnepf, Daniel; Beer, Julius; Deantoneo, Carly; Williams, Riley M.; Shubina, Maria; Livingston, Brandi; Zhang, Dingqiang; Andrake, Mark D.; Lee, Seungheon; Boda, Raghavender; Duddupudi, Anantha L.; Crawford, Jeremy Chase; Vogel, Peter; Loch, Christian; Schwemmle, Martin; Fritz, Lawrence C.; Schultz-Cherry, Stacey; Green, Douglas R.; Cuny, Gregory D.; Thomas, Paul G.; Degterev, Alexei; Balachandran, Siddharth
  作者单位：Fox Chase Cancer Center; St Jude Children's Research Hospital; St Jude Children's Research Hospital; University of California System; University of California Santa Cruz; University of Houston System; University of Houston; Tufts University; University of Freiburg; St Jude Children's Research Hospital; Reaction Biology
  摘要：Severe influenza A virus (IAV) infections can result in hyper-inflammation, lung injury and acute respiratory distress syndrome1-5 (ARDS), for which there are no effective pharmacological therapies. Necroptosis is an attractive entry point for therapeutic intervention in ARDS and related inflammatory conditions because it drives pathogenic lung inflammation and lethality during severe IAV infection6-8 and can potentially be targeted by receptor interacting protein kinase 3 (RIPK3) inhibitors. ...
• Will AI accelerate or delay the race to net-zero emissions? AI翻译
  作者：Luers, Amy; Koomey, Jonathan; Masanet, Eric; Gaffney, Owen; Creutzig, Felix; Ferres, Juan Lavista; Horvitz, Eric
  作者单位：Microsoft; University of California System; University of California Santa Barbara; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Technical University of Berlin; Technical University of Berlin; Microsoft
  摘要：As artificial intelligence transforms the global economy, researchers need to explore scenarios to assess how it can help, rather than harm, the climate.