8009期

最新文章

• ICE SPY: SOUTH POLE DETECTOR FINALLY SPOTS TAU NEUTRINO AI翻译
  作者：[Anonymous]
• Antisense oligonucleotide therapeutic approach for Timothy syndrome AI翻译
  作者：Chen, Xiaoyu; Birey, Fikri; Li, Min-Yin; Revah, Omer; Levy, Rebecca; Thete, Mayuri Vijay; Reis, Noah; Kaganovsky, Konstantin; Onesto, Massimo; Sakai, Noriaki; Hudacova, Zuzana; Hao, Jin; Meng, Xiangling; Nishino, Seiji; Huguenard, John; Pasca, Sergiu
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Emory University
  摘要：Timothy syndrome (TS) is a severe, multisystem disorder characterized by autism, epilepsy, long-QT syndrome and other neuropsychiatric conditions 1 . TS type 1 (TS1) is caused by a gain-of-function variant in the alternatively spliced and developmentally enriched CACNA1C exon 8A, as opposed to its counterpart exon 8. We previously uncovered several phenotypes in neurons derived from patients with TS1, including delayed channel inactivation, prolonged depolarization-induced calcium rise, impair...
• Charles Darwin investigates: the curious case of primrose punishment AI翻译
  作者：Darwin, Charles
• How ground glass might save crops from drought on this Caribbean island AI翻译
  作者：Powell, Kendall
  摘要：In Grenada, public-health researcher Lindonne Telesford tests a soil additive made from recycled glass that could help farmers adapt to climate change.
• Graphene nanoribbons grown in hBN stacks for high-performance electronics AI翻译
  作者：Lyu, Bosai; Chen, Jiajun; Wang, Sen; Lou, Shuo; Shen, Peiyue; Xie, Jingxu; Qiu, Lu; Mitchell, Izaac; Li, Can; Hu, Cheng; Zhou, Xianliang; Watanabe, Kenji; Taniguchi, Takashi; Wang, Xiaoqun; Jia, Jinfeng; Liang, Qi; Chen, Guorui; Li, Tingxin; Wang, Shiyong; Ouyang, Wengen; Hod, Oded; Ding, Feng; Urbakh, Michael; Shi, Zhiwen
  作者单位：Shanghai Jiao Tong University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Wuhan University; Wuhan University; Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); National Institute for Materials Science; National Institute for Materials Science; Shanghai Jiao Tong University; Tel Aviv University; Tel Aviv University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS
  摘要：Van der Waals encapsulation of two-dimensional materials in hexagonal boron nitride (hBN) stacks is a promising way to create ultrahigh-performance electronic devices(1-4). However, contemporary approaches for achieving van der Waals encapsulation, which involve artificial layer stacking using mechanical transfer techniques, are difficult to control, prone to contamination and unscalable. Here we report the transfer-free direct growth of high-quality graphene nanoribbons (GNRs) in hBN stacks. ...
• The rural wastewater challenge AI翻译
  作者：Huang, Jinlou; Li, Duo; Coulon, Frederic; Yang, Xiao Jin
  作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Qingdao University; Cranfield University; Peking University
  摘要：Letter to the Editor
• Optical clocks at sea AI翻译
  作者：Roslund, Jonathan D.; Cingoez, Arman; Lunden, William D.; Partridge, Guthrie B.; Kowligy, Abijith S.; Roller, Frank; Sheredy, Daniel B.; Skulason, Gunnar E.; Song, Joe P.; Abo-Shaeer, Jamil R.; Boyd, Martin M.
  摘要：Deployed optical clocks will improve positioning for navigational autonomy 1 , provide remote time standards for geophysical monitoring 2 and distributed coherent sensing 3 , allow time synchronization of remote quantum networks 4,5 and provide operational redundancy for national time standards. Although laboratory optical clocks now reach fractional inaccuracies below 10-18 (refs. 6,7 ), transportable versions of these high-performing clocks 8,9 have limited utility because of their size, env...
• WHALES TAKE TO THE SHALLOWS TO SAND DOWN PARASITES AI翻译
  作者：[Anonymous]
• Landscape-scale benefits of protected areas for tropical biodiversity (vol 620, pg 807, 2023) AI翻译
  作者：Brodie, Jedediah F.; Mohd-Azlan, Jayasilan; Chen, Cheng; Wearn, Oliver R.; Deith, Mairin C. M.; Ball, James G. C.; Slade, Eleanor M.; Burslem, David F. R. P.; Teoh, Shu Woan; Williams, Peter J.; Nguyen, An; Moore, Jonathan H.; Goetz, Scott J.; Burns, Patrick; Jantz, Patrick; Hakkenberg, Christopher R.; Kaszta, Zaneta M.; Cushman, Sam; Coomes, David; Helmy, Olga E.; Reynolds, Glen; Rodriguez, Jon Paul; Jetz, Walter; Luskin, Matthew Scott
• A brain-specific angiogenic mechanism enabled by tip cell specialization AI翻译
  作者：Schevenels, Giel; Cabochette, Pauline; America, Michelle; Vandenborne, Arnaud; De Grande, Line; Guenther, Stefan; He, Liqun; Dieu, Marc; Christou, Basile; Vermeersch, Marjorie; Germano, Raoul F. V.; Perez-Morga, David; Renard, Patricia; Martin, Maud; Vanlandewijck, Michael; Betsholtz, Christer; Vanhollebeke, Benoit
  作者单位：Max Planck Society; Uppsala University; University of Namur; Karolinska Institutet
  摘要：Vertebrate organs require locally adapted blood vessels 1,2 . The gain of such organotypic vessel specializations is often deemed to be molecularly unrelated to the process of organ vascularization. Here, opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operates under the control of Wnt7a/b ligands-well-known blood-brain barrier maturation signals 3-5 . The control mechanism relies on Wnt7a/b-dependent expression of Mmp25, which we find is enriched in b...