-
作者：Pillai, Arvind; Idris, Abbas; Philomin, Annika; Weidle, Connor; Skotheim, Rebecca; Leung, Philip J. Y.; Broerman, Adam; Demakis, Cullen; Borst, Andrew J.; Praetorius, Florian; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Institute of Science & Technology - Austria
摘要：Allosteric modulation of protein function, wherein the binding of an effector to a protein triggers conformational changes at distant functional sites, plays a central part in the control of metabolism and cell signalling1-3. There has been considerable interest in designing allosteric systems, both to gain insight into the mechanisms underlying such 'action at a distance' modulation and to create synthetic proteins whose functions can be regulated by effectors4-7. However, emulating the subtl...
-
作者：Newcombe, Patrick B.
作者单位：Princeton University
-
作者：Heyne, Henrike O.
作者单位：University of Potsdam
摘要：Genetic variants in RNU4-2, a gene in a part of the genome not usually in the spotlight, have been identified as the cause of a developmental disorder in a large number of individuals who previously lacked a diagnosis.
-
作者：Mathys, Hansruedi; Boix, Carles A.; Akay, Leyla Anne; Xia, Ziting; Davila-Velderrain, Jose; Ng, Ayesha P.; Jiang, Xueqiao; Abdelhady, Ghada; Galani, Kyriaki; Mantero, Julio; Band, Neil; James, Benjamin T.; Babu, Sudhagar; Galiana-Melendez, Fabiola; Louderback, Kate; Prokopenko, Dmitry; Tanzi, Rudolph E.; Bennett, David A.; Tsai, Li-Huei; Kellis, Manolis
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Human Technopole; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Rush University; Stanford University
摘要：Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways that underlie its pathological progression across brain regions remain poorly understood(1-3). Here we report a single-cell transcriptomic atlas of six different brain regions in the aged human brain, covering 1.3million cells from 283 post-mortem human brain samples across 48 individuals with and without Alzheimer's disease. We identify 76 cell types, including region-specific subtypes of astrocytes and ...
-
作者：Dohare, Shibhansh; Hernandez-Garcia, J. Fernando; Lan, Qingfeng; Rahman, Parash; Mahmood, A. Rupam; Sutton, Richard S.
作者单位：University of Alberta
摘要：Artificial neural networks, deep-learning methods and the backpropagation algorithm(1) form the foundation of modern machine learning and artificial intelligence. These methods are almost always used in two phases, one in which the weights of the network are updated and one in which the weights are held constant while the network is used or evaluated. This contrasts with natural learning and many applications, which require continual learning. It has been unclear whether or not deep learning m...
-
作者：Crease, Robert P.
作者单位：State University of New York (SUNY) System; Stony Brook University
-
作者：Mroz, Przemek; Udalski, Andrzej; Szymanski, Michal K.; Soszynski, Igor; Wyrzykowski, Lukasz; Pietrukowicz, Pawel; Kozlowski, Szymon; Poleski, Radoslaw; Skowron, Jan; Skowron, Dorota; Ulaczyk, Krzysztof; Gromadzki, Mariusz; Rybicki, Krzysztof; Iwanek, Patryk; Wrona, Marcin; Ratajczak, Milena
作者单位：University of Warsaw; University of Warwick; Weizmann Institute of Science
摘要：The gravitational wave detectors have shown a population of massive black holes that do not resemble those observed in the Milky Way1-3 and whose origin is debated4-6. According to a possible explanation, these black holes may have formed from density fluctuations in the early Universe (primordial black holes)7-9, and they should comprise several to 100% of dark matter to explain the observed black hole merger rates10-12. If these black holes existed in the Milky Way dark matter halo, they wou...
-
作者：Crew, Bec
-
作者：Kozlov, Max
摘要：The Africa Centres for Disease Control and Prevention also issued an emergency declaration as several countries see their first cases of the disease caused by the monkeypox virus.
-
作者：Driver, Taran; Mountney, Miles; Wang, Jun; Ortmann, Lisa; Al-Haddad, Andre; Berrah, Nora; Bostedt, Christoph; Champenois, Elio G.; DiMauro, Louis F.; Duris, Joseph; Garratt, Douglas; Glownia, James M.; Guo, Zhaoheng; Haxton, Daniel; Isele, Erik; Ivanov, Igor; Ji, Jiabao; Kamalov, Andrei; Li, Siqi; Lin, Ming-Fu; Marangos, Jon P.; Obaid, Razib; O'Neal, Jordan T.; Rosenberger, Philipp; Shivaram, Niranjan H.; Wang, Anna L.; Walter, Peter; Wolf, Thomas J. A.; Woerner, Hans Jakob; Zhang, Zhen; Bucksbaum, Philip H.; Kling, Matthias F.; Landsman, Alexandra S.; Lucchese, Robert R.; Emmanouilidou, Agapi; Marinelli, Agostino; Cryan, James P.
作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of London; University College London; Stanford University; University System of Ohio; Ohio State University; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; University of Connecticut; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Imperial College London; KLA Corporation; Institute for Basic Science - Korea (IBS); Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Munich; Max Planck Society; Purdue University System; Purdue University; Purdue University System; Purdue University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：The photoelectric effect is not truly instantaneous but exhibits attosecond delays that can reveal complex molecular dynamics(1-7). Sub-femtosecond-duration light pulses provide the requisite tools to resolve the dynamics of photoionization(8-12). Accordingly, the past decade has produced a large volume of work on photoionization delays following single-photon absorption of an extreme ultraviolet photon. However, the measurement of time-resolved core-level photoionization remained out of reach...
