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作者：Chen, Hsiao-Chi; He, Peihao; McDonald, Malcolm; Williamson, Michael R.; Varadharajan, Srinidhi; Lozzi, Brittney; Woo, Junsung; Choi, Dong-Joo; Sardar, Debosmita; Huang-Hobbs, Emmet; Sun, Hua; Ippagunta, Siri M.; Jain, Antrix; Rao, Ganesh; Merchant, Thomas E.; Ellison, David W.; Noebels, Jeffrey L.; Bertrand, Kelsey C.; Mack, Stephen C.; Deneen, Benjamin
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; St Jude Children's Research Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Baylor College of Medicine; Baylor College of Medicine; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital
摘要：Bidirectional communication between tumours and neurons has emerged as a key facet of the tumour microenvironment that drives malignancy(1,2). Another hallmark feature of cancer is epigenomic dysregulation, in which alterations in gene expression influence cell states and interactions with the tumour microenvironment(3). Ependymoma (EPN) is a paediatric brain tumour that relies on epigenomic remodelling to engender malignancy(4,5); however, how these epigenetic mechanisms intersect with extrin...
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作者：Ma, Shoucai; An, Chunpeng; Lawson, Aaron W.; Cao, Yu; Sun, Yue; Tan, Eddie Yong Jun; Pan, Jinheng; Jirschitzka, Jan; Kuemmel, Florian; Mukhi, Nitika; Han, Zhifu; Feng, Shan; Wu, Bin; Schulze-Lefert, Paul; Chai, Jijie
作者单位：Westlake Laboratory; Westlake University; Xianghu Laboratory; Max Planck Society; Nanyang Technological University; University of Cologne; Max Planck Society
摘要：Nucleotide-binding leucine-rich repeat (NLR) proteins play a pivotal role in plant immunity by recognizing pathogen effectors1,2. Maintaining a balanced immune response is crucial, as excessive NLR expression can lead to unintended autoimmunity3,4. Unlike most NLRs, the plant NLR required for cell death 2 (NRC2) belongs to a small NLR group characterized by constitutively high expression without self-activation5. The mechanisms underlying NRC2 autoinhibition and activation are not yet understo...
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作者：Chen, Yuyang; Dawes, Ruebena; Kim, Hyung Chul; Ljungdahl, Alicia; Stenton, Sarah L.; Walker, Susan; Lord, Jenny; Lemire, Gabrielle; Martin-Geary, Alexandra C.; Ganesh, Vijay S.; Ma, Jialan; Ellingford, Jamie M.; Delage, Erwan; D'Souza, Elston N.; Dong, Shan; Adams, David R.; Allan, Kirsten; Bakshi, Madhura; Baldwin, Erin E.; Berger, Seth I.; Bernstein, Jonathan A.; Bhatnagar, Ishita; Blair, Ed; Brown, Natasha J.; Burrage, Lindsay C.; Chapman, Kimberly; Coman, David J.; Compton, Alison G.; Cunningham, Chloe A.; D'Souza, Precilla; Danecek, Petr; Delot, Emmanuele C.; Dias, Kerith-Rae; Elias, Ellen R.; Elmslie, Frances; Evans, Care-Anne; Ewans, Lisa; Ezell, Kimberly; Fraser, Jamie L.; Gallacher, Lyndon; Genetti, Casie A.; Goriely, Anne; Grant, Christina L.; Haack, Tobias; Higgs, Jenny E.; Hinch, Anjali G.; Hurles, Matthew E.; Kuechler, Alma; Lachlan, Katherine L.; Lalani, Seema R.; Lecoquierre, Francois; Leitao, Elsa; Le Fevre, Anna; Leventer, Richard J.; Liebelt, Jan E.; Lindsay, Sarah; Lockhart, Paul J.; Ma, Alan S.; Macnamara, Ellen F.; Mansour, Sahar; Maurer, Taylor M.; Mendez, Hector R.; Metcalfe, Kay; Montgomery, Stephen B.; Moosajee, Mariya; Nassogne, Marie-Cecile; Neumann, Serena; O'Donoghue, Michael; O'Leary, Melanie; Palmer, Elizabeth E.; Pattani, Nikhil; Phillips, John; Pitsava, Georgia; Pysar, Ryan; Rehm, Heidi L.; Reuter, Chloe M.; Revencu, Nicole; Riess, Angelika; Rius, Rocio; Rodan, Lance; Roscioli, Tony; Rosenfeld, Jill A.; Sachdev, Rani; Shaw-Smith, Charles J.; Simons, Cas; Sisodiya, Sanjay M.; Snell, Penny; St Clair, Laura; Stark, Zornitza; Stewart, Helen S.; Tan, Tiong Yang; Tan, Natalie B.; Temple, Suzanna E. L.; Thorburn, David R.; Tifft, Cynthia J.; Uebergang, Eloise; VanNoy, Grace E.; Vasudevan, Pradeep; Vilain, Eric; Viskochil, David H.; Wedd, Laura; Wheeler, Matthew T.; White, Susan M.; Wojcik, Monica; Wolfe, Lynne A.; Wolfenson, Zoe; Wright, Caroline F.; Xiao, Changrui; Zocche, David; Rubenstein, John L.; Markenscoff-Papadimitriou, Eirene; Fica, Sebastian M.; Baralle, Diana; Depienne, Christel; MacArthur, Daniel G.; Howson, Joanna M. M.; Sanders, Stephan J.; O'Donnell-Luria, Anne; Whiffin, Nicola
作者单位：University of Oxford; University of Oxford; Wellcome Centre for Human Genetics; University of Oxford; University of California System; University of California San Francisco; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Sheffield; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Manchester University NHS Foundation Trust; University of Manchester; Wellcome Trust Sanger Institute; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Murdoch Children's Research Institute; Victorian Clinical Genetics Services; Liverpool Hospital; Utah System of Higher Education; University of Utah; Children's National Health System; Children's National Health System; Stanford University; Stanford University; Stanford University; Oxford University Hospitals NHS Foundation Trust; University of Melbourne; Baylor College of Medicine; Childrens Health Queensland Hospital & Health Service; Queensland Childrens Hospital; University of Queensland; Griffith University; Griffith University - Gold Coast Campus; Murdoch Children's Research Institute; Neuroscience Research Australia; University of New South Wales Sydney; Children's Hospital Colorado; University of Colorado System; University of Colorado Anschutz Medical Campus; University of New South Wales Sydney; Prince of Wales Hospital (POWH); University of New South Wales Sydney; NSW Health; Sydney Childrens Hospitals Network; Garvan Institute of Medical Research; Vanderbilt University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Oxford; University of Oxford; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; University of Liverpool; University of Duisburg Essen; University of Southampton; Universite de Rouen Normandie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Rouen Normandie; CHU de Rouen; Royal Children's Hospital Melbourne; Murdoch Children's Research Institute; NSW Health; Sydney Childrens Hospitals Network; University of Sydney; Stanford University; Stanford University; University of Manchester; Manchester University NHS Foundation Trust; Stanford University; University of London; University College London; Francis Crick Institute; University of London; University College London; Moorfields Eye Hospital NHS Foundation Trust; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Nottingham University Hospital NHS Trust; University of California System; University of California Irvine; University of Sydney; NSW Health; Sydney Childrens Hospitals Network; The Children's Hospital at Westmead; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Garvan Institute of Medical Research; University of New South Wales Sydney; Murdoch Children's Research Institute; University of London; University College London; University of New South Wales Sydney; University of Leicester; University of California System; University of California Irvine; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; University of Exeter; University of California System; University of California Irvine; Imperial College London; Imperial College London; University of California System; University of California San Francisco; University of Oxford; University of Southampton; University of Southampton; University Hospital Southampton NHS Foundation Trust
摘要：Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed after comprehensive genetic testing, primarily of protein-coding genes1. Large genome-sequenced cohorts are improving our ability to discover new diagnoses in the non-coding genome. Here we identify the non-coding RNA RNU4-2 as a syndromic NDD gene. RNU4-2 encodes the U4 small nuclear RNA (snRNA), which is a critical component of the U4/U6.U5 tri-snRNP complex of the major spliceosome2. We identify an 18 base ...
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作者：Liu, Chi; Wang, Xin-Zhe; Shen, Cong; Ma, Lai-Peng; Yang, Xu-Qi; Kong, Yue; Ma, Wei; Liang, Yan; Feng, Shun; Wang, Xiao-Yue; Wei, Yu-Ning; Zhu, Xi; Li, Bo; Li, Chang-Ze; Dong, Shi-Chao; Zhang, Li-Ning; Ren, Wen-Cai; Sun, Dong-Ming; Cheng, Hui-Ming
作者单位：Chinese Academy of Sciences; Institute of Metal Research, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS
摘要：Hot-carrier transistors are a class of devices that leverage the excess kinetic energy of carriers. Unlike regular transistors, which rely on steady-state carrier transport, hot-carrier transistors modulate carriers to high-energy states, resulting in enhanced device speed and functionality. These characteristics are essential for applications that demand rapid switching and high-frequency operations, such as advanced telecommunications and cutting-edge computing technologies(1-5). However, th...
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作者：Gross, Nicolas; Maestre, Fernando T.; Liancourt, Pierre; Berdugo, Miguel; Martin, Raphael; Gozalo, Beatriz; Ochoa, Victoria; Delgado-Baquerizo, Manuel; Maire, Vincent; Saiz, Hugo; Soliveres, Santiago; Valencia, Enrique; Eldridge, David J.; Guirado, Emilio; Jabot, Franck; Asensio, Sergio; Gaitan, Juan J.; Garcia-Gomez, Miguel; Martinez, Paloma; Martinez-Valderrama, Jaime; Mendoza, Betty J.; Moreno-Jimenez, Eduardo; Pescador, David S.; Plaza, Cesar; Pijuan, Ivan Santaolaria; Abedi, Mehdi; Ahumada, Rodrigo J.; Amghar, Fateh; Arroyo, Antonio I.; Bahalkeh, Khadijeh; Bailey, Lydia; Ben Salem, Farah; Blaum, Niels; Boldgiv, Bazartseren; Bowker, Matthew A.; Branquinho, Cristina; van den Brink, Liesbeth; Bu, Chongfeng; Canessa, Rafaella; Castillo-Monroy, Andrea del P.; Castro, Helena; Castro, Patricio; Chibani, Roukaya; Conceicao, Abel Augusto; Darrouzet-Nardi, Anthony; Davila, Yvonne C.; Deak, Balazs; Donoso, David A.; Duran, Jorge; Espinosa, Carlos; Fajardo, Alex; Farzam, Mohammad; Ferrante, Daniela; Franzese, Jorgelina; Fraser, Lauchlan; Gonzalez, Sofia; Gusman-Montalvan, Elizabeth; Hernandez-Hernandez, Rosa Mary; Hoelzel, Norbert; Huber-Sannwald, Elisabeth; Jadan, Oswaldo; Jeltsch, Florian; Jentsch, Anke; Ju, Mengchen; Kaseke, Kudzai F.; Kindermann, Liana; le Roux, Peter; Linstaedter, Anja; Louw, Michelle A.; Mabaso, Mancha; Maggs-Koelling, Gillian; Makhalanyane, Thulani P.; Issa, Oumarou Malam; Manzaneda, Antonio J.; Marais, Eugene; Margerie, Pierre; Hughes, Frederic Mendes; Messeder, Joo Vitor S.; Mora, Juan P.; Moreno, Gerardo; Munson, Seth M.; Nunes, Alice; Oliva, Gabriel; Onatibia, Gaston R.; Peter, Guadalupe; Pueyo, Yolanda; Quiroga, R. Emiliano; Ramirez-Iglesias, Elizabeth; Reed, Sasha C.; Rey, Pedro J.; Reyes Gomez, Victor M.; Rodriguez, Alexandra; Rolo, Victor; Rubalcaba, Juan G.; Ruppert, Jan C.; Sala, Osvaldo; Salah, Ayman; Sebei, Phokgedi Julius; Stavi, Ilan; Stephens, Colton; Teixido, Alberto L.; Thomas, Andrew D.; Throop, Heather L.; Tielboerger, Katja; Travers, Samantha; Undrakhbold, Sainbileg; Val, James; Valko, Orsolya; Velbert, Frederike; Wamiti, Wanyoike; Wang, Lixin; Wang, Deli; Wardle, Glenda M.; Wolff, Peter; Yahdjian, Laura; Yari, Reza; Zaady, Eli; Zeberio, Juan Manuel; Zhang, Yuanling; Zhou, Xiaobing; Le Bagousse-Pinguet, Yoann
作者单位：VetAgro Sup; Universite Clermont Auvergne (UCA); INRAE; King Abdullah University of Science & Technology; Eberhard Karls University of Tubingen; Complutense University of Madrid; Swiss Federal Institutes of Technology Domain; ETH Zurich; Universitat d'Alacant; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); University of Quebec; University of Quebec Trois Rivieres; University of Zaragoza; Universitat d'Alacant; University of New South Wales Sydney; Instituto Nacional de Tecnologia Agropecuaria (INTA); Universidad Nacional de Lujan; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Universidad Politecnica de Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencias Agrarias (ICA); Universidad Rey Juan Carlos; Autonomous University of Madrid; Complutense University of Madrid; Tarbiat Modares University; Instituto Nacional de Tecnologia Agropecuaria (INTA); Universite de M'hammed Bougara Boumerdes; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Pirenaico de Ecologia (IPE); Northern Arizona University; Universite de Gabes; University of Potsdam; National University of Mongolia; Northern Arizona University; Universidade de Lisboa; Universidade de Lisboa; Universidad de Concepcion; Chinese Academy of Sciences; Institute of Soil & Water Conservation (ISWC), CAS; Northwest A&F University - China; Chinese Academy of Sciences; Institute of Soil & Water Conservation (ISWC), CAS; Ministry of Water Resources; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Martin Luther University Halle Wittenberg; Escuela Politecnica Nacional Ecuador; Universidade de Coimbra; Universidad de Cuenca; Universite de Gabes; Universidade Estadual de Feira de Santana; University of Texas System; University of Texas El Paso; University of Technology Sydney; HUN-REN; HUN-REN Centre for Ecological Research; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Mision Biologica de Galicia (MBG); Universidad Tecnica Particular de Loja; Universidad de Talca; Ferdowsi University Mashhad; Universidad Nacional de la Patagonia San Juan Bosco; Universidad Nacional del Comahue; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Thompson Rivers University; University of Munster; Instituto Potosino Investigacion Cientifica y Tecnologica; University of Bayreuth; University of California System; University of California Santa Barbara; University of Potsdam; University of Pretoria; University of Bonn; University of Pretoria; Stellenbosch University; Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Sorbonne Universite; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); INRAE; Universite Paris Cite; Universidad de Jaen; Universite de Rouen Normandie; INRAE; Universidade Estadual de Santa Cruz; Universidade Estadual de Santa Cruz; Universidade Federal de Minas Gerais; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Universidad de Extremadura; United States Department of the Interior; United States Geological Survey; University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); United States Department of the Interior; United States Geological Survey; Universidad de Cordoba; Universidad de Jaen; University of Granada; Instituto Interuniversitario de Investigacion del Sistema Tierra en Andalucia; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Al-Quds University; Aberystwyth University; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of New South Wales Sydney; Northeast Normal University - China; University of Sydney; Chinese Academy of Sciences; Xinjiang Institute of Ecology & Geography, CAS; Avignon Universite; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD)
摘要：Earth harbours an extraordinary plant phenotypic diversity(1) that is at risk from ongoing global changes(2,3). However, it remains unknown how increasing aridity and livestock grazing pressure-two major drivers of global change(4-6)-shape the trait covariation that underlies plant phenotypic diversity(1,7). Here we assessed how covariation among 20 chemical and morphological traits responds to aridity and grazing pressure within global drylands. Our analysis involved 133,769 trait measurement...
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作者：Forrester, Nikki
摘要：Geophysicist Natalia Cisternas embarked on a 37-day voyage to document microbes in a low-oxygen region of the Pacific Ocean.
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作者：Garisto, Dan
摘要：Whistleblowers raise questions about the processing and sharing of raw data.
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作者：Crow, James Mitchell
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作者：Courellis, Hristos S.; Minxha, Juri; Cardenas, Araceli R.; Kimmel, Daniel L.; Reed, Chrystal M.; Valiante, Taufik A.; Salzman, C. Daniel; Mamelak, Adam N.; Fusi, Stefano; Rutishauser, Ueli
作者单位：Cedars Sinai Medical Center; California Institute of Technology; Columbia University; Krembil Research Institute; University of Toronto; University Health Network Toronto; University of Toronto; University Health Network Toronto; Columbia University; Cedars Sinai Medical Center; New York State Psychiatry Institute; Columbia University; Columbia University; Cedars Sinai Medical Center
摘要：Humans have the remarkable cognitive capacity to rapidly adapt to changing environments. Central to this capacity is the ability to form high-level, abstract representations that take advantage of regularities in the world to support generalization1. However, little is known about how these representations are encoded in populations of neurons, how they emerge through learning and how they relate to behaviour2,3. Here we characterized the representational geometry of populations of neurons (si...
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作者：Plackett, Benjamin
