8033期

最新文章

• Don't overshoot: why carbon dioxide removal will achieve too little, too late AI翻译
  作者：[Anonymous]
  摘要：Many climate scenarios bake in a temperature overshoot before technologies are used to scrub the atmosphere clean of emissions. Emerging science says that is probably a fool's errand.
• How a potent immune therapy loses its punch against a blood cancer AI翻译
  作者：[Anonymous]
  摘要：Therapeutic T cells used to treat acute myeloid leukaemia secrete proteins that impair the cells' own ability to attack cancer.
• The periosteum provides a stromal defence against cancer invasion into the bone AI翻译
  作者：Nakamura, Kazutaka; Tsukasaki, Masayuki; Tsunematsu, Takaaki; Yan, Minglu; Ando, Yutaro; Huynh, Nam Cong-Nhat; Hashimoto, Kyoko; Gou, Qiao; Muro, Ryunosuke; Itabashi, Ayumi; Iguchi, Takahiro; Okamoto, Kazuo; Nakamura, Takashi; Nakano, Kenta; Okamura, Tadashi; Ueno, Tomoya; Ito, Kosei; Ishimaru, Naozumi; Hoshi, Kazuto; Takayanagi, Hiroshi
  作者单位：University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; Tokushima University; University of Texas System; University of Texas Southwestern Medical Center; Hochiminh City University of Medicine & Pharmacy; Tokyo University of Science; Kanazawa University; Tokyo Dental College; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; Nagasaki University; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
  摘要：The periosteum is the layer of cells that covers nearly the entire surface of every bone. Upon infection, injury or malignancy the bone surface undergoes new growth-the periosteal reaction-but the mechanism and physiological role of this process remain unknown1,2. Here we show that the periosteal reaction protects against cancer invasion into the bone. Histological analyses of human lesions of head and neck squamous cell carcinomas (HNSCCs) show that periosteal thickening occurs in proximity t...
• I embrace traditional roots in Argentinian winemaking AI翻译
  作者：Austin, Alexia; Kuri, Micaela
  摘要：Working as an oenologist brings to life an important aspect of my country's cultural identity.
• South Korea's emissions-reduction plan declared unconstitutional in a landmark climate case AI翻译
  作者：Jon, WooJung
  作者单位：Korea Advanced Institute of Science & Technology (KAIST)
• Overconfidence in climate overshoot AI翻译
  作者：Schleussner, Carl-Friedrich; Ganti, Gaurav; Lejeune, Quentin; Zhu, Biqing; Pfleiderer, Peter; Pruetz, Ruben; Ciais, Philippe; Froelicher, Thomas L.; Fuss, Sabine; Gasser, Thomas; Gidden, Matthew J.; Kropf, Chahan M.; Lacroix, Fabrice; Lamboll, Robin; Martyr, Rosanne; Maussion, Fabien; McCaughey, Jamie W.; Meinshausen, Malte; Mengel, Matthias; Nicholls, Zebedee; Quilcaille, Yann; Sanderson, Benjamin; Seneviratne, Sonia I.; Sillmann, Jana; Smith, Christopher J.; Steinert, Norman J.; Theokritoff, Emily; Warren, Rachel; Price, Jeff; Rogelj, Joeri
  作者单位：International Institute for Applied Systems Analysis (IIASA); Humboldt University of Berlin; Humboldt University of Berlin; Universite Paris Saclay; University of Hamburg; Imperial College London; University of Bern; University of Bern; Potsdam Institut fur Klimafolgenforschung; Swiss Federal Institutes of Technology Domain; ETH Zurich; Federal Office of Meteorology & Climatology (MeteoSwiss); University of Bern; Imperial College London; University of Innsbruck; University of Bristol; University of Melbourne; Met Office - UK; Hadley Centre; University of Leeds; University of East Anglia; University of East Anglia
  摘要：Global emission reduction efforts continue to be insufficient to meet the temperature goal of the Paris Agreement1. This makes the systematic exploration of so-called overshoot pathways that temporarily exceed a targeted global warming limit before drawing temperatures back down to safer levels a priority for science and policy2-5. Here we show that global and regional climate change and associated risks after an overshoot are different from a world that avoids it. We find that achieving decli...
• The Israel-Hamas conflict one year on: researcher resilience in the face of war AI翻译
  作者：Glausiusz, Josie
  摘要：Scientists, tech entrepreneurs and educators on both sides of the border describe the devastation of lost homes, destroyed laboratories and slain colleagues. Scientists, tech entrepreneurs and educators on both sides of the border describe the devastation of lost homes, destroyed laboratories and slain colleagues.
• A roadmap for affordable genetic medicines AI翻译
  作者：Kliegman, Melinda; Zaghlula, Manar; Abrahamson, Susan; Esensten, Jonathan H.; Wilson, Ross C.; Urnov, Fyodor D.; Doudna, Jennifer A.
  作者单位：University of California System; University of California Berkeley; Tel Aviv University; Chaim Sheba Medical Center; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Twenty genetic therapies have been approved by the US Food and Drug Administration to date, a number that now includes the first CRISPR genome-editing therapy for sickle cell disease-CASGEVY (exagamglogene autotemcel, Vertex Pharmaceuticals). This extraordinary milestone is widely celebrated owing to the promise for future genome-editing treatments of previously intractable genetic disorders and cancers. At the same time, such genetic therapies are the most expensive drugs on the market, with ...
• Multi-qubit gates and Schrödinger cat states in an optical clock AI翻译
  作者：Cao, Alec; Eckner, William J.; Yelin, Theodor Lukin; Young, Aaron W.; Jandura, Sven; Yan, Lingfeng; Kim, Kyungtae; Pupillo, Guido; Ye, Jun; Oppong, Nelson Darkwah; Kaufman, Adam M.
  作者单位：University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC)
  摘要：Many-particle entanglement is a key resource for achieving the fundamental precision limits of a quantum sensor1. Optical atomic clocks2, the current state of the art in frequency precision, are a rapidly emerging area of focus for entanglement-enhanced metrology3-6. Augmenting tweezer-based clocks featuring microscopic control and detection7-10 with the high-fidelity entangling gates developed for atom-array information processing11,12 offers a promising route towards making use of highly ent...
• Architecture and activation mechanism of the bacterial PARIS defence system AI翻译
  作者：Deep, Amar; Liang, Qishan; Enustun, Eray; Pogliano, Joe; Corbett, Kevin D.
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Bacteria and their viruses (bacteriophages or phages) are engaged in an intense evolutionary arms race(1-5). While the mechanisms of many bacterial antiphage defence systems are known(1), how these systems avoid toxicity outside infection yet activate quickly after infection is less well understood. Here we show that the bacterial phage anti-restriction-induced system (PARIS) operates as a toxin-antitoxin system, in which the antitoxin AriA sequesters and inactivates the toxin AriB until trigg...