8033期

最新文章

• Revolutionary drug for schizophrenia wins US approval AI翻译
  作者：Dolgin, Elie
• GPS tracking reveals how hares shape lynx populations AI翻译
  作者：Klopper, Abigail
• The genetic architecture of protein stability AI翻译
  作者：Faure, Andre J.; Marti-Aranda, Aina; Hidalgo-Carcedo, Cristina; Beltran, Antoni; Schmiedel, Joern M.; Lehner, Ben
  作者单位：Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Wellcome Trust Sanger Institute; Pompeu Fabra University
  摘要：There are more ways to synthesize a 100-amino acid (aa) protein (20100) than there are atoms in the universe. Only a very small fraction of such a vast sequence space can ever be experimentally or computationally surveyed. Deep neural networks are increasingly being used to navigate high-dimensional sequence spaces1. However, these models are extremely complicated. Here, by experimentally sampling from sequence spaces larger than 1010, we show that the genetic architecture of at least some pro...
• Stem cells reverse woman's diabetes - a world first AI翻译
  作者：Mallapaty, Smriti
• Nobel prizes are globally unrepresentative - the nomination process must be opened up AI翻译
  作者：[Anonymous]
  摘要：The geography of science is changing. As a result, a big push is needed to broaden the pool of scientists eligible to nominate their peers for Nobel prizes.
• Which is the fairest electoral system? Mega-election year sparks debate AI翻译
  作者：Skibba, Ramin
  摘要：Proportional representation or winner takes all? Here's how researchers compare the merits of contrasting voting methods.
• A γδ T cell-IL-3 axis controls allergic responses through sensory neurons AI翻译
  作者：Flayer, Cameron H.; Kernin, Isabela J.; Matatia, Peri R.; Zeng, Xiangsunze; Yarmolinsky, David A.; Han, Cai; Naik, Parth R.; Buttaci, Dean R.; Aderhold, Pamela A.; Camire, Ryan B.; Zhu, Xueping; Tirard, Alice J.; McGuire, John T.; Smith, Neal P.; McKimmie, Clive S.; McAlpine, Cameron S.; Swirski, Filip K.; Woolf, Clifford J.; Villani, Alexandra-Chloe; Sokol, Caroline L.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; University of York - UK; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：In naive individuals, sensory neurons directly detect and respond to allergens, leading to both the sensation of itch and the activation of local innate immune cells, which initiate the allergic immune response1,2. In the setting of chronic allergic inflammation, immune factors prime sensory neurons, causing pathologic itch3-7. Although these bidirectional neuroimmune circuits drive responses to allergens, whether immune cells regulate the set-point for neuronal activation by allergens in the ...
• A population code for spatial representation in the zebrafish telencephalon AI翻译
  作者：Yang, Chuyu; Mammen, Lorenz; Kim, Byoungsoo; Li, Meng; Robson, Drew N.; Li, Jennifer M.
  作者单位：Max Planck Society; Eberhard Karls University of Tubingen; Cornell University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS
  摘要：Spatial learning in teleost fish requires an intact telencephalon(1), a brain region that contains putative analogues to components of the mammalian limbic system (for example, hippocampus)(2-4). However, cells fundamental to spatial cognition in mammals-for example, place cells (PCs)(5,6)-have yet to be established in any fish species. In this study, using tracking microscopy to record brain-wide calcium activity in freely swimming larval zebrafish(7), we compute the spatial information conte...
• Drosophila immune cells transport oxygen through PPO2 protein phase transition (Vol 631, pg 350, 2024) AI翻译
  作者：Shin, Mingyu; Chang, Eunji; Lee, Daewon; Kim, Nayun; Cho, Bumsik; Cha, Nuri; Koranteng, Ferdinand; Song, Ji-Joon; Shim, Jiwon
  作者单位：Hanyang University; Korea Advanced Institute of Science & Technology (KAIST); Hanyang University; Hanyang University; Hanyang University
• A virally encoded tRNA neutralizes the PARIS antiviral defence system AI翻译
  作者：Burman, Nathaniel; Belukhina, Svetlana; Depardieu, Florence; Wilkinson, Royce A.; Skutel, Mikhail; Santiago-Frangos, Andrew; Graham, Ava B.; Livenskyi, Alexei; Chechenina, Anna; Morozova, Natalia; Zahl, Trevor; Henriques, William S.; Buyukyoruk, Murat; Rouillon, Christophe; Saudemont, Baptiste; Shyrokova, Lena; Kurata, Tatsuaki; Hauryliuk, Vasili; Severinov, Konstantin; Groseille, Justine; Thierry, Agnes; Koszul, Romain; Tesson, Florian; Bernheim, Aude; Bikard, David; Wiedenheft, Blake; Isaev, Artem
  作者单位：Montana State University System; Montana State University Bozeman; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Russian Academy of Sciences; Institute of Gene Biology (IGB) of Russian Academy of Sciences; Lomonosov Moscow State University; Peter the Great St. Petersburg Polytechnic University; Lund University; Lund University; Rutgers University System; Rutgers University New Brunswick
  摘要：Viruses compete with each other for limited cellular resources, and some deliver defence mechanisms that protect the host from competing genetic parasites1. The phage antirestriction induced system (PARIS) is a defence system, often encoded in viral genomes, that is composed of a 55 kDa ABC ATPase (AriA) and a 35 kDa TOPRIM nuclease (AriB)2. However, the mechanism by which AriA and AriB function in phage defence is unknown. Here we show that AriA and AriB assemble into a 425 kDa supramolecular...