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作者：Ceppi, Ilaria; Dello Stritto, Maria Rosaria; Muetze, Martin; Braunshier, Stefan; Mengoli, Valentina; Reginato, Giordano; Ho My Phuc Vo; Jimeno, Sonia; Acharya, Ananya; Roy, Megha; Sanchez, Aurore; Halder, Swagata; Howard, Sean Michael; Guerois, Raphael; Huertas, Pablo; Noordermeer, Sylvie M.; Seidel, Ralf; Cejka, Petr
作者单位：Universita della Svizzera Italiana; Leipzig University; Leiden University; Leiden University Medical Center (LUMC); University of Sevilla; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; CNRS - National Institute for Biology (INSB); Boise State University
摘要：DNA double-strand break (DSB) repair by homologous recombination is initiated by DNA end resection, a process involving the controlled degradation of the 5-terminated strands at DSB sites(1,2). The breast cancer suppressor BRCA1-BARD1 not only promotes resection and homologous recombination, but it also protects DNA upon replication stress(1,3-9). BRCA1-BARD1 counteracts the anti-resection and pro-non-homologous end-joining factor 53BP1, but whether it functions in resection directly has been ...
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作者：Yue, Wendy W. S.; Touhara, Kouki K.; Toma, Kenichi; Duan, Xin; Julius, David
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：After injury, mammalian spinal cords develop scars to confine the lesion and prevent further damage. However, excessive scarring can hinder neural regeneration and functional recovery1,2. These competing actions underscore the importance of developing therapeutic strategies to dynamically modulate scar progression. Previous research on scarring has primarily focused on astrocytes, but recent evidence has suggested that ependymal cells also participate. Ependymal cells normally form the epithel...
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作者：Aryal, Achyut
作者单位：Tribhuvan University; Institute of Forestry (IOF) - Nepal; University of Technology Sydney
摘要：Governments should encourage researchers to stay and boost the economies of their home countries rather than working overseas.
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作者：Francl, Michelle
作者单位：Bryn Mawr College; Vatican Observatory
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作者：Ozer, Emre; Kufel, Jedrzej; Prakash, Shvetank; Raisiardali, Alireza; Kindgren, Olof; Wong, Ronald; Ng, Nelson; Jausseran, Damien; Alkhalil, Feras; Kong, David; Hills, Gage; Price, Richard; Reddi, Vijay Janapa
作者单位：Harvard University
摘要：Semiconductors have already had a very profound effect on society, accelerating scientific research and driving greater connectivity. Future semiconductor hardware will open up new possibilities in quantum computing, artificial intelligence and edge computing, for applications such as cybersecurity and personalized healthcare. By nature of its ethos, open hardware provides opportunities for even greater collaboration and innovations across education, academic research and industry. Here we pre...
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作者：Callaway, Ewen
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作者：Poole, Danielle N.; Ranney, Megan L.
作者单位：Yale University
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作者：Yang, Lan; Ding, Guodong
作者单位：Shanghai Jiao Tong University
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作者：Takaoka, Minoru; Zhao, Xiaohui; Lim, Hwee Ying; Magnussen, Costan G.; Ang, Owen; Suffee, Nadine; Schrank, Patricia R.; Ong, Wei Siong; Tsiantoulas, Dimitrios; Sommer, Felix; Mohanta, Sarajo K.; Harrison, James; Meng, Yaxing; Laurans, Ludivine; Wu, Feitong; Lu, Yuning; Masters, Leanne; Newland, Stephen A.; Denti, Laura; Hong, Mingyang; Chajadine, Mouna; Juonala, Markus; Koskinen, Juhani S.; Kaehoenen, Mika; Pahkala, Katja; Rovio, Suvi P.; Mykkaenen, Juha; Thomson, Russell; Kaisho, Tsuneyasu; Habenicht, Andreas J. R.; Clement, Marc; Tedgui, Alain; Ait-Oufella, Hafid; Zhao, Tian X.; Nus, Meritxell; Ruhrberg, Christiana; Taleb, Soraya; Williams, Jesse W.; Raitakari, Olli T.; Angeli, Veronique; Mallat, Ziad
作者单位：University of Cambridge; National University of Singapore; National University of Singapore; University of Turku; University of Turku; University of Turku; Baker Heart and Diabetes Institute; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Minnesota System; University of Minnesota Twin Cities; Medical University of Vienna; University of Kiel; University of Kiel; Schleswig Holstein University Hospital; University of Munich; University of London; University College London; University of Turku; University of Turku; Satakunta Central Hospital; Tampere University; Tampere University; Tampere University; Wakayama Medical University; University of Turku
摘要：Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk1. Furthermore, LDL-C fluctuations are associated with ASCVD outcomes2-4. However, the precise mechanisms behind this increased ASCVD risk are not understood. Here we find tha...
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作者：Finkelstein, Ran; Tsai, Richard Bing-Shiun; Sun, Xiangkai; Scholl, Pascal; Direkci, Su; Gefen, Tuvia; Choi, Joonhee; Shaw, Adam L.; Endres, Manuel
作者单位：California Institute of Technology; Stanford University
摘要：Enhancing the precision of measurements by harnessing entanglement is a long-sought goal in quantum metrology1,2. Yet attaining the best sensitivity allowed by quantum theory in the presence of noise is an outstanding challenge, requiring optimal probe-state generation and read-out strategies3-7. Neutral-atom optical clocks8, which are the leading systems for measuring time, have shown recent progress in terms of entanglement generation9-11 but at present lack the control capabilities for real...
