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作者：Hung, King L.; Jones, Matthew G.; Wong, Ivy Tsz-Lo; Curtis, Ellis J.; Lange, Joshua T.; He, Britney Jiayu; Luebeck, Jens; Schmargon, Rachel; Scanu, Elisa; Brueckner, Lotte; Yan, Xiaowei; Li, Rui; Gnanasekar, Aditi; Gonzalez, Rocio Chamorro; Belk, Julia A.; Liu, Zhonglin; Melillo, Bruno; Bafna, Vineet; Doerr, Jan R.; Werner, Benjamin; Huang, Weini; Cravatt, Benjamin F.; Henssen, Anton G.; Mischel, Paul S.; Chang, Howard Y.
作者单位：Stanford University; Stanford University; Stanford University; University of California System; University of California San Diego; University of California System; University of California San Diego; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; University of London; Queen Mary University London; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Scripps Research Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of London; Queen Mary University London; Sun Yat Sen University; Helmholtz Association; German Cancer Research Center (DKFZ); Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Stanford University; Howard Hughes Medical Institute; Stanford University
摘要：The chromosomal theory of inheritance dictates that genes on the same chromosome segregate together while genes on different chromosomes assort independently1. Extrachromosomal DNAs (ecDNAs) are common in cancer and drive oncogene amplification, dysregulated gene expression and intratumoural heterogeneity through random segregation during cell division2,3. Distinct ecDNA sequences, termed ecDNA species, can co-exist to facilitate intermolecular cooperation in cancer cells4. How multiple ecDNA ...
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作者：Reardon, Sara
摘要：Models suggest societal upheaval from anti-obesity medicines - but impacts are hard to predict.
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作者：Choi, Gyohun; Sullivan, Patrick; Lv, Xiu-Liang; Li, Wenjie; Lee, Kwanpyung; Kong, Haoyu; Gessler, Sam; Schmidt, J. R.; Feng, Dawei
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Aqueous redox flow batteries with halide-based catholytes (where the halogen atom (X) is Br or I) are promising for sustainable grid energy storage. However, the formation of polyhalides during electrochemical charging and the associated phase separation into X2 limits the operable state of charge (SoC), results in vaporization and self-discharge inefficiencies, and spurs complete device failure1-3. Here we introduce soft-hard zwitterionic trappers (SH-ZITs) as complexing agents composed of a ...
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作者：Zhou, Hao; Hu, Jiashun; Zilio, Luca Dal; Tang, Ming; Li, Keqing; Hu, Xiumian
作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Nanyang Technological University; Nanyang Technological University; Peking University; Nanjing University
摘要：The fast increase of convergence rate between India and Eurasia around 65 million years ago (Ma)-from approximately 8 cm yr(-1) to a peak rate of approximately 18 cm yr(-1)-remains a complex geological event to explain(1-8), given the inherent uncertainty surrounding the tectonic history and the intricate interplay of forces influencing plate speed(9-11). Here we use a combination of geochemical analysis and geodynamic modelling to propose that this rapid convergence can be explained by sedime...
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作者：[Anonymous]
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作者：Ran, Jiangjun; Ditmar, Pavel; van den Broeke, Michiel R.; Liu, Lin; Klees, Roland; Khan, Shfaqat Abbas; Moon, Twila; Li, Jiancheng; Bevis, Michael; Zhong, Min; Fettweis, Xavier; Liu, Junguo; Noel, Brice; Shum, C. K.; Chen, Jianli; Jiang, Liming; van Dam, Tonie
作者单位：Southern University of Science & Technology; Delft University of Technology; Utrecht University; Chinese University of Hong Kong; Technical University of Denmark; University of Colorado System; University of Colorado Boulder; Central South University; Wuhan University; Wuhan University; University System of Ohio; Ohio State University; Sun Yat Sen University; University of Liege; North China University of Water Resources & Electric Power; North China University of Water Resources & Electric Power; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Utah System of Higher Education; University of Utah
摘要：The Greenland ice sheet (GrIS) is at present the largest single contributor to global-mass-induced sea-level rise, primarily because of Arctic amplification on an increasingly warmer Earth(1-5). However, the processes of englacial water accumulation, storage and ultimate release remain poorly constrained. Here we show that a noticeable amount of the summertime meltwater mass is temporally buffered along the entire GrIS periphery, peaking in July and gradually reducing thereafter. Our results a...
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作者：Matthews, David
摘要：Anti-immigration parties are pushing policies that are hostile or indifferent towards science.
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作者：Kozlov, Max
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作者：Reardon, Sara
摘要：Tools such as Rosetta and AlphaFold have redefined the protein-engineering landscape. But some problems remain out of reach - for now.
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作者：Michilli, Daniele
作者单位：Massachusetts Institute of Technology (MIT)
摘要：Powerful bursts of radio waves from distant galaxies are typically linked to young celestial objects. But observations reveal that they are more likely to occur in rarer, more massive galaxies, offering clues to their enigmatic origins.
