2024

最新文章

• I strive to make the Great Barrier Reef more resilient to heat stress AI翻译
  作者：Crow, James Mitchell; Nitschke, Matthew
  作者单位：Australian Institute of Marine Science; Victoria University Wellington
• Support those who will lose out in the energy transition AI翻译
  作者：[Anonymous]
• FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy AI翻译
  作者：Chan, Jack D.; Scheffler, Christina M.; Munoz, Isabelle; Sek, Kevin; Lee, Joel N.; Huang, Yu-Kuan; Yap, Kah Min; Saw, Nicole Y. L.; Li, Jasmine; Chen, Amanda X. Y.; Chan, Cheok Weng; Derrick, Emily B.; Todd, Kirsten L.; Tong, Junming; Dunbar, Phoebe A.; Li, Jiawen; Hoang, Thang X.; de Menezes, Maria N.; Petley, Emma V.; Kim, Joelle S.; Nguyen, Dat; Leung, Patrick S. K.; So, Joan; Deguit, Christian; Zhu, Joe; House, Imran G.; Kats, Lev M.; Scott, Andrew M.; Solomon, Benjamin J.; Harrison, Simon J.; Oliaro, Jane; Parish, Ian A.; Quinn, Kylie M.; Neeson, Paul J.; Slaney, Clare Y.; Lai, Junyun; Beavis, Paul A.; Darcy, Phillip K.
  作者单位：Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; University of Melbourne; Royal Melbourne Institute of Technology (RMIT); La Trobe University; Olivia Newton-John Cancer Research Institute; La Trobe University; University of Melbourne; Peter Maccallum Cancer Center; Melbourne Health; Royal Melbourne Hospital; Monash University; Monash University
  摘要：Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma 1-4 , but the efficacy of CAR T cell therapy in solid tumours has been limited 5 . This is owing to a number of factors, including the immunosuppressive tumour microenvironment that gives rise to poorly persisting and metabolically dysfunctional T cells. Analysis of anti-CD19 CAR T cells used clinically has shown...
• How volcanoes shaped our planet - and why we need to be ready for the next big eruption AI翻译
  作者：Handley, Heather
  作者单位：University of Twente
  摘要：The world should learn from past disasters and prepare for the effects of future, inevitable volcanic catastrophes, a wide-reaching book teaches us. The world should learn from past disasters and prepare for the effects of future, inevitable volcanic catastrophes, a wide-reaching book teaches us.
• Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia AI翻译
  作者：Koeberl, Dwight; Schulze, Andreas; Sondheimer, Neal; Lipshutz, Gerald S.; Geberhiwot, Tarekegn; Li, Lerong; Saini, Rajnish; Luo, Junxiang; Sikirica, Vanja; Jin, Ling; Liang, Min; Leuchars, Mary; Grunewald, Stephanie
  作者单位：Duke University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of California System; University of California Los Angeles; University of Birmingham; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of London; University College London
  摘要：Propionic acidaemia is a rare disorder caused by defects in the propionyl-coenzyme A carboxylase alpha or beta (PCCA or PCCB) subunits that leads to an accumulation of toxic metabolites and to recurrent, life-threatening metabolic decompensation events. Here we report interim analyses of a first-in-human, phase 1/2, open-label, dose-optimization study and an extension study evaluating the safety and efficacy of mRNA-3927, a dual mRNA therapy encoding PCCA and PCCB. As of 31 May 2023, 16 partic...
• Targeting RNA opens therapeutic avenues for Timothy syndrome AI翻译
  作者：Velasco, Silvia
  作者单位：Murdoch Children's Research Institute
  摘要：A therapeutic strategy that alters gene expression in a rare and severe neurodevelopmental condition has been tested in stem-cell-based models of the disease, and has been shown to correct genetic and cellular defects.
• Nature exhibits scientist portraits AI翻译
  作者：Leeming, Jack
• Macromolecular condensation buffers intracellular water potential (vol 623, pg 842, 2023) AI翻译
  作者：Watson, Joseph L.; Seinkmane, Estere; Styles, Christine T.; Mihut, Andrei; Kruger, Lara K.; McNally, Kerrie E.; Planelles-Herrero, Vicente Jose; Dudek, Michal; McCall, Patrick M.; Barbiero, Silvia; Oever, Michael Vanden; Peak-Chew, Sew Yeu; Porebski, Benjamin T.; Zeng, Aiwei; Rzechorzek, Nina M.; Wong, David C. S.; Beale, Andrew D.; Stangherlin, Alessandra; Riggi, Margot; Iwasa, Janet; Morf, Jorg; Miliotis, Christos; Guna, Alina; Inglis, Alison J.; Brugues, Jan; Voorhees, Rebecca M.; Chambers, Joseph E.; Meng, Qing-Jun; O'Neill, John S.; Edgar, Rachel S.; Derivery, Emmanuel
• Robust optical clocks promise stable timing in a portable package AI翻译
  作者：Marlow, Bonnie L. S.; Hirschauer, Jonathan
  作者单位：MITRE Corporation
  摘要：A highly precise timekeeping instrument has been adapted for the real world. The compact and robust device is smaller than its commercial counterparts and performs comparably in the laboratory and aboard a naval ship.
• The Middle East's largest hypersaline lake risks turning into an environmental disaster zone AI翻译
  作者：Mohammadi, Alireza; Azareh, Ali; Khanjani, Mohammad Hossein; Sharifinia, Moslem
  摘要：Letter to the Editor