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作者：Marchesan, Silvia
作者单位：University of Trieste
摘要：A simple peptide has been found to make disordered interactions with water, forming a self-healing glass that can also be used as an adhesive coating. The findings point the way to sustainable alternatives to conventional glass.
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作者：Guan, Xiangnan; Hu, Ruozhen; Choi, Yoonha; Srivats, Shyam; Nabet, Barzin Y.; Silva, John; Mcginnis, Lisa; Hendricks, Robert; Nutsch, Katherine; Banta, Karl L.; Duong, Ellen; Dunkle, Alexis; Chang, Patrick S.; Han, Chia-Jung; Mittman, Stephanie; Molden, Nandini; Daggumati, Pallavi; Connolly, Wendy; Johnson, Melissa; Abreu, Delvys Rodriguez; Cho, Byoung Chul; Italiano, Antoine; Gil-Bazo, Ignacio; Felip, Enriqueta; Mellman, Ira; Mariathasan, Sanjeev; Shames, David S.; Meng, Raymond; Chiang, Eugene Y.; Johnston, Robert J.; Patil, Namrata S.
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作者：Chaudun, Fabrice; Python, Laurena; Liu, Yu; Hiver, Agnes; Cand, Jennifer; Kieffer, Brigitte L.; Valjent, Emmanuel; Luescher, Christian
作者单位：University of Geneva; Universite de Lorraine; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Geneva
摘要：Fentanyl is a powerful painkiller that elicits euphoria and positive reinforcement(1). Fentanyl also leads to dependence, defined by the aversive withdrawal syndrome, which fuels negative reinforcement(2,3) (that is, individuals retake the drug to avoid withdrawal). Positive and negative reinforcement maintain opioid consumption, which leads to addiction in one-fourth of users, the largest fraction for all addictive drugs(4). Among the opioid receptors, mu-opioid receptors have a key role(5), ...
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作者：Dowding, Ian; Schuh, Christopher A.
作者单位：Massachusetts Institute of Technology (MIT); Northwestern University
摘要：The strength of materials depends on the rate at which they are tested, as defects, for example dislocations, that move in response to applied strains have intrinsic kinetic limitations(1-4). As the deformation strain rate increases, more strengthening mechanisms become active and increase the strength(4-7). However, the regime in which this transition happens has been difficult to access with traditional micromechanical strength measurements. Here, with microballistic impact testing at strain...
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作者：Zhang, Heng; Yin, Yu-Ling; Dai, Antao; Zhang, Tianwei; Zhang, Chao; Wu, Canrong; Hu, Wen; He, Xinheng; Pan, Benxun; Jin, Sanshan; Yuan, Qingning; Wang, Ming-Wei; Yang, Dehua; Xu, H. Eric; Jiang, Yi
作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Lingang Laboratory; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; ShanghaiTech University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Hainan Medical University
摘要：The noradrenaline transporter has a pivotal role in regulating neurotransmitter balance and is crucial for normal physiology and neurobiology(1). Dysfunction of noradrenaline transporter has been implicated in numerous neuropsychiatric diseases, including depression and attention deficit hyperactivity disorder(2). Here we report cryo-electron microscopy structures of noradrenaline transporter in apo and substrate-bound forms, and as complexes with six antidepressants. The structures reveal a n...
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作者：Zhang, Yiwen; Li, Xiang; Ba, Zhaoqing; Lou, Jiangman; Gaertner, K. Elyse; Zhu, Tammie; Lin, Xin; Ye, Adam Yongxin; Alt, Frederick W.; Hu, Hongli
作者单位：Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School; National Institute of Biological Sciences, Beijing; University of Copenhagen; Georgetown University
摘要：In developing B cells, V(D)J recombination assembles exons encoding IgH and Ig kappa variable regions from hundreds of gene segments clustered across Igh and Igk loci. V, D and J gene segments are flanked by conserved recombination signal sequences (RSSs) that target RAG endonuclease(1). RAG orchestrates Igh V(D)J recombination upon capturing a J(H)-RSS within the J(H)-RSS-based recombination centre(1-3) (RC). J(H)-RSS orientation programmes RAG to scan upstream D- and V-H-containing chromatin...
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作者：Eldjarn, Grimur Hjorleifsson; Ferkingstad, Egil; Lund, Sigrun H.; Helgason, Hannes; Magnusson, Olafur Th.; Gunnarsdottir, Kristbjorg; Olafsdottir, Thorunn A.; Halldorsson, Bjarni V.; Olason, Pall I.; Zink, Florian; Gudjonsson, Sigurjon A.; Sveinbjornsson, Gardar; Magnusson, Magnus I.; Helgason, Agnar; Oddsson, Asmundur; Halldorsson, Gisli H.; Magnusson, Magnus K.; Saevarsdottir, Saedis; Eiriksdottir, Thjodbjorg; Masson, Gisli; Stefansson, Hreinn; Jonsdottir, Ingileif; Holm, Hilma; Rafnar, Thorunn; Melsted, Pall; Saemundsdottir, Jona; Norddahl, Gudmundur L.; Thorleifsson, Gudmar; Ulfarsson, Magnus O.; Gudbjartsson, Daniel F.; Thorsteinsdottir, Unnur; Sulem, Patrick; Stefansson, Kari
作者单位：Decode Genetics; University of Iceland; Reykjavik University; University of Iceland; University of Iceland; University of Iceland
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作者：Fan, Yandong; Huang, Weian; Zhu, Fei; Liu, Xingsi; Jin, Chunqi; Guo, Chenzi; An, Yang; Kivshar, Yuri; Qiu, Cheng-Wei; Li, Wei
作者单位：Chinese Academy of Sciences; Changchun Institute of Optics, Fine Mechanics & Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National University of Singapore; Australian National University; Harbin Engineering University
摘要：Intensity, polarization and wavelength are intrinsic characteristics of light. Characterizing light with arbitrarily mixed information on polarization and spectrum is in high demand(1-4). Despite the extensive efforts in the design of polarimeters(5-18) and spectrometers(19-27), concurrently yielding high-dimensional signatures of intensity, polarization and spectrum of the light fields is challenging and typically requires complicated integration of polarization- and/or wavelength-sensitive e...
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作者：Fairbank, Rachel
摘要：Semaglutide, the same compound in obesity drug Wegovy, slashes risk of kidney failure and death for people with diabetes.
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作者：Jin, Wenlong; Yang, Chi-Yuan; Pau, Riccardo; Wang, Qingqing; Tekelenburg, Eelco K.; Wu, Han-Yan; Wu, Ziang; Jeong, Sang Young; Pitzalis, Federico; Liu, Tiefeng; He, Qiao; Li, Qifan; Huang, Jun-Da; Kroon, Renee; Heeney, Martin; Woo, Han Young; Mura, Andrea; Motta, Alessandro; Facchetti, Antonio; Fahlman, Mats; Loi, Maria Antonietta; Fabiano, Simone
作者单位：Linkoping University; University of Groningen; University of Cagliari; Korea University; Linkoping University; Imperial College London; Imperial College London; Sapienza University Rome; University System of Georgia; Georgia Institute of Technology
摘要：Chemical doping is an important approach to manipulating charge-carrier concentration and transport in organic semiconductors (OSCs)(1-3) and ultimately enhances device performance(4-7). However, conventional doping strategies often rely on the use of highly reactive (strong) dopants(8-10), which are consumed during the doping process. Achieving efficient doping with weak and/or widely accessible dopants under mild conditions remains a considerable challenge. Here, we report a previously undes...
