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作者：Else, Holly
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作者：Pasham, Dheeraj R.; Zajacek, Michal; Nixon, C. J.; Coughlin, Eric R.; Sniegowska, Marzena; Janiuk, Agnieszka; Czerny, Bozena; Wevers, Thomas; Guolo, Muryel; Ajay, Yukta; Loewenstein, Michael
作者单位：Massachusetts Institute of Technology (MIT); Masaryk University; University of Leeds; Syracuse University; Tel Aviv University; Polish Academy of Sciences; Center for Theoretical Physics - Polish Academy of Sciences; Space Telescope Science Institute; European Southern Observatory; Johns Hopkins University; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
摘要：An accretion disk formed around a supermassive black hole after it disrupts a star is expected to be initially misaligned with respect to the equatorial plane of the black hole. This misalignment induces relativistic torques (the Lense-Thirring effect) on the disk, causing the disk to precess at early times, whereas at late times the disk aligns with the black hole and precession terminates(1,2). Here we report, using high-cadence X-ray monitoring observations of a tidal disruption event (TDE)...
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作者：Hu, Jinhong; Park, Sung Jin; Walter, Tyler; Orozco, Ian J.; O'Dea, Garrett; Ye, Xinyu; Du, Juan; Lue, Wei
作者单位：Van Andel Institute; Zoetis
摘要：Temperature profoundly affects macromolecular function, particularly in proteins with temperature sensitivity(1,2). However, its impact is often overlooked in biophysical studies that are typically performed at non-physiological temperatures, potentially leading to inaccurate mechanistic and pharmacological insights. Here we demonstrate temperature-dependent changes in the structure and function of TRPM4, a temperature-sensitive Ca2+-activated ion channel(3-7). By studying TRPM4 prepared at ph...
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作者：Zhao, Yanyu; Huang, Gaoxingyu; Wu, Qiurong; Wu, Kun; Li, Ruiqi; Lei, Jianlin; Pan, Xiaojing; Yan, Nieng
作者单位：Westlake University; Westlake University; Tsinghua University; Capital Medical University; Tsinghua University; Princeton University
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作者：Li, Linsen; De Santis, Lorenzo; Harris, Isaac B. W.; Chen, Kevin C.; Gao, Yihuai; Christen, Ian; Choi, Hyeongrak; Trusheim, Matthew; Song, Yixuan; Errando-Herranz, Carlos; Du, Jiahui; Hu, Yong; Clark, Genevieve; Ibrahim, Mohamed I.; Gilbert, Gerald; Han, Ruonan; Englund, Dirk
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Delft University of Technology; United States Department of Defense; US Army Research, Development & Engineering Command (RDECOM); US Army Research Laboratory (ARL); United States Army; University of Munster; MITRE Corporation; Cornell University; MITRE Corporation
摘要：Colour centres in diamond have emerged as a leading solid-state platform for advancing quantum technologies, satisfying the DiVincenzo criteria1 and recently achieving quantum advantage in secret key distribution2. Blueprint studies3-5 indicate that general-purpose quantum computing using local quantum communication networks will require millions of physical qubits to encode thousands of logical qubits, presenting an open scalability challenge. Here we introduce a modular quantum system-on-chi...
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作者：Zhang, Shouyue; Sun, Ao; Qian, Jing-Mei; Lin, Shuo; Xing, Wenjing; Yang, Yun; Zhu, Han-Zhou; Zhou, Xin-Yi; Guo, Yan-Shuo; Liu, Yun; Meng, Yu; Jin, Shu-Lin; Song, Wenhao; Li, Cheng-Ping; Li, Zhaofu; Jin, Shuai; Wang, Jian-Hua; Dong, Meng-Qiu; Gao, Caixia; Chen, Chunlai; Bai, Yang; Liu, Jun-Jie Gogo
作者单位：Tsinghua University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; National Institute of Biological Sciences, Beijing; Tsinghua University; Peking University
摘要：The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA(1). As part of the ongoing struggle between phages and the bacterial immune system, the CRISPR system has evolved into various types, each with distinct functionalities(2). Type II Cas9 is the most extensively studied of these systems and has diverse subtypes. It remains uncertain whether members of this family can evolve additional mechanisms to counter viral invasio...
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作者：Brown, Jane
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作者：Munoz, Kristen A.; Ulrich, Rebecca J.; Vasan, Archit K.; Sinclair, Matt; Wen, Po-Chao; Holmes, Jessica R.; Lee, Hyang Yeon; Hung, Chien-Che; Fields, Christopher J.; Tajkhorshid, Emad; Lau, Gee W.; Hergenrother, Paul J.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Infections caused by Gram-negative pathogens are increasingly prevalent and are typically treated with broad-spectrum antibiotics, resulting in disruption of the gut microbiome and susceptibility to secondary infections(1-3). There is a critical need for antibiotics that are selective both for Gram-negative bacteria over Gram-positive bacteria, as well as for pathogenic bacteria over commensal bacteria. Here we report the design and discovery of lolamicin, a Gram-negative-specific antibiotic t...
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作者：Yamada-Hunter, Sean A.; Theruvath, Johanna; McIntosh, Brianna J.; Freitas, Katherine A.; Lin, Frank; Radosevich, Molly T.; Leruste, Amaury; Dhingra, Shaurya; Martinez-Velez, Naiara; Xu, Peng; Huang, Jing; Delaidelli, Alberto; Desai, Moksha H.; Good, Zinaida; Polak, Roel; May, Audre; Labanieh, Louai; Bjelajac, Jeremy; Murty, Tara; Ehlinger, Zach; Mount, Christopher W.; Chen, Yiyun; Heitzeneder, Sabine; Marjon, Kristopher D.; Banuelos, Allison; Khan, Omair; Wasserman, Savannah L.; Spiegel, Jay Y.; Fernandez-Pol, Sebastian; Kuo, Calvin J.; Sorensen, Poul H.; Monje, Michelle; Majzner, Robbie G.; Weissman, Irving L.; Sahaf, Bita; Sotillo, Elena; Cochran, Jennifer R.; Mackall, Crystal L.
作者单位：Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; British Columbia Cancer Agency; Stanford University; Stanford University; Princess Maxima Center; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford Cancer Institute; University of Miami; Stanford University; Stanford University; Stanford University; Stanford University
摘要：Adoptively transferred T cells and agents designed to block the CD47-SIRP alpha axis are promising cancer therapeutics that activate distinct arms of the immune system(1,2). Here we administered anti-CD47 antibodies in combination with adoptively transferred T cells with the goal of enhancing antitumour efficacy but observed abrogated therapeutic benefit due to rapid macrophage-mediated clearance of T cells expressing chimeric antigen receptors (CARs) or engineered T cell receptors. Anti-CD47-...
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作者：Kozlov, Max; Wolf, Lauren
摘要：Long-awaited testimony ends in fireworks as US lawmakers spar over the former infectious-disease official's pandemic actions.
