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作者：[Anonymous]
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作者：[Anonymous]
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作者：Tomar, A.; Gomez-Velazquez, M.; Gerlini, R.; Comas-Armangue, G.; Makharadze, L.; Kolbe, T.; Boersma, A.; Dahlhoff, M.; Burgstaller, J. P.; Lassi, M.; Darr, J.; Toppari, J.; Virtanen, H.; Kuehnapfel, A.; Scholz, M.; Landgraf, K.; Kiess, W.; Vogel, M.; Gailus-Durner, V.; Fuchs, H.; Marschall, S.; Hrabe de Angelis, M.; Kotaja, N.; Koerner, A.; Teperino, R.
作者单位：Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; German Center for Diabetes Research (DZD); University of Veterinary Medicine Vienna; BOKU University; University of Veterinary Medicine Vienna; BOKU University; University of Turku; University of Turku; University of Turku; Leipzig University; Leipzig University; Leipzig University; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Leipzig University; Leipzig University
摘要：Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs)(1), which influences offspring development and adult phenotypes(1-7). Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood(8). Here we used two distinct paradigms of preconception acute high-fat diet to dissect epididymal versus testicular contributions to the sperm sncRNA pool and offspring health. We show that epididymal spermatozoa, but not ...
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作者：Eisenstein, Michael
摘要：A steadily growing toolbox is giving researchers the ability to monitor and measure the physical forces that shape embryonic development.
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作者：Lewis, Dyani; Abbott, Alison
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作者：Nordling, Linda
摘要：Our first global survey of research group leaders and other hiring managers seeks to capture recruitment highs and lows in the current climate.
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作者：Alang, Sirry
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Racism is a systemic issue - one that we have the knowledge and tools to solve. But is there a will?
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作者：He, Guang; Loffler, Frank E.
作者单位：University of Tennessee System; University of Tennessee Knoxville
摘要：Innovative solutions are needed to decrease greenhouse-gas emissions. Field trials show that supplementing farm soil with a bacterium that consumes the greenhouse gas nitrous oxide can substantially lower harmful emissions.
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作者：Du, Gang; Healy, Liam B.; David, Liron; Walker, Caitlin; El-Baba, Tarick J.; Lutomski, Corinne A.; Goh, Byoungsook; Gu, Bowen; Pi, Xiong; Devant, Pascal; Fontana, Pietro; Dong, Ying; Ma, Xiyu; Miao, Rui; Balasubramanian, Arumugam; Puthenveetil, Robbins; Banerjee, Anirban; Luo, Hongbo R.; Kagan, Jonathan C.; Oh, Sungwhan F.; Robinson, Carol V.; Lieberman, Judy; Wu, Hao
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); University of Oxford; University of Oxford; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); Ben-Gurion University of the Negev; CSL
摘要：Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores after cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)1-10. Here we report that GSDMD Cys191 is S-palmitoylated and that palmitoylation is required for pore formation. S-palmitoylation, which does not affect GSDMD cleavage, is augmented by mitochondria-generated reactive oxygen speci...
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作者：Finkelstein-Zuta, Gal; Arnon, Zohar A.; Vijayakanth, Thangavel; Messer, Or; Lusky, Orr Simon; Wagner, Avital; Zilberman, Galit; Aizen, Ruth; Michaeli, Lior; Rencus-Lazar, Sigal; Gilead, Sharon; Shankar, Sudha; Pavan, Mariela Jorgelina; Goldstein, Dor Aaron; Kutchinsky, Shira; Ellenbogen, Tal; Palmer, Benjamin A.; Goldbourt, Amir; Sokol, Maxim; Gazit, Ehud
作者单位：Tel Aviv University; Tel Aviv University; Tel Aviv University; Ben-Gurion University of the Negev; Elbit Systems; California Institute of Technology; Tel Aviv University; Ben-Gurion University of the Negev; Tel Aviv University; Columbia University
摘要：Despite its disordered liquid-like structure, glass exhibits solid-like mechanical properties1. The formation of glassy material occurs by vitrification, preventing crystallization and promoting an amorphous structure2. Glass is fundamental in diverse fields of materials science, owing to its unique optical, chemical and mechanical properties as well as durability, versatility and environmental sustainability3. However, engineering a glassy material without compromising its properties is chall...
