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作者：Lewis, Kim; Lee, Richard E.; Broetz-Oesterhelt, Heike; Hiller, Sebastian; Rodnina, Marina V.; Schneider, Tanja; Weingarth, Markus; Wohlgemuth, Ingo
作者单位：Northeastern University; St Jude Children's Research Hospital; University of Basel; University of Bonn; German Center for Infection Research; Utrecht University
摘要：In this Review, we explore natural product antibiotics that do more than simply inhibit an active site of an essential enzyme. We review these compounds to provide inspiration for the design of much-needed new antibacterial agents, and examine the complex mechanisms that have evolved to effectively target bacteria, including covalent binders, inhibitors of resistance, compounds that utilize self-promoted entry, those that evade resistance, prodrugs, target corrupters, inhibitors of 'undruggabl...
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作者：Maddaloni, G.; Chang, Y. J.; Senft, R. A.; Dymecki, S. M.
作者单位：Harvard University; Harvard Medical School
摘要：Changes in the amount of daylight (photoperiod) alter physiology and behaviour(1,2). Adaptive responses to seasonal photoperiods are vital to all organisms-dysregulation associates with disease, including affective disorders(3) and metabolic syndromes(4). The circadian rhythm circuitry is implicated in such responses(5,6), yet little is known about the precise cellular substrates that underlie phase synchronization to photoperiod change. Here we identify a brain circuit and system of axon bran...
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作者：[Anonymous]
摘要：Observations of electron neutrinos could allow physicists to test theories about the particles' behaviour.
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作者：Bourzac, Katherine
摘要：Success with a new route to producing superheavy elements paves the way to making the elusive element 120.
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作者：Drew, Liam
摘要：It's a transformational time long neglected by neuroscience. That is starting to change.
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作者：[Anonymous]
摘要：A bouquet of genes involved in making volatile compounds helps to produce the flower's characteristic scent.
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作者：Wharton, Jack H.; Renoult, Martin; Gebbie, Geoffrey; Keigwin, Lloyd D.; Marchitto, Thomas M.; Maslin, Mark A.; Oppo, Delia W.; Thornalley, David J. R.
作者单位：University of London; University College London; Stockholm University; Woods Hole Oceanographic Institution; University of Colorado System; University of Colorado Boulder
摘要：Subtropical gyre (STG) depth and strength are controlled by wind stress curl and surface buoyancy forcing(1,2). Modern hydrographic data reveal that the STG extends to a depth of about 1 km in the Northwest Atlantic, with its maximum depth defined by the base of the subtropical thermocline. Despite the likelihood of greater wind stress curl and surface buoyancy loss during the Last Glacial Maximum (LGM)(3), previous work suggests minimal change in the depth of the glacial STG(4). Here we show ...
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作者：Tasfaout, Hichem; Halbert, Christine L.; McMillen, Timothy S.; Allen, James M.; Reyes, Theodore R.; Flint, Galina V.; Grimm, Dirk; Hauschka, Stephen D.; Regnier, Michael; Chamberlain, Jeffrey S.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; German Center for Infection Research; German Centre for Cardiovascular Research; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Gene replacement using adeno-associated virus (AAV) vectors is a promising therapeutic approach for many diseases(1,2). However, this therapeutic modality is challenged by the packaging capacity of AAVs (approximately 4.7 kilobases)(3), limiting its application for disorders involving large coding sequences, such as Duchenne muscular dystrophy, with a 14 kilobase messenger RNA. Here we developed a new method for expressing large dystrophins by utilizing the protein trans-splicing mechanism med...
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作者：Siegel, Joshua S.; Subramanian, Subha; Perry, Demetrius; Kay, Benjamin P.; Gordon, Evan M.; Laumann, Timothy O.; Reneau, T. Rick; Metcalf, Nicholas V.; Chacko, Ravi V.; Gratton, Caterina; Horan, Christine; Krimmel, Samuel R.; Shimony, Joshua S.; Schweiger, Julie A.; Wong, Dean F.; Bender, David A.; Scheidter, Kristen M.; Whiting, Forrest I.; Padawer-Curry, Jonah A.; Shinohara, Russell T.; Chen, Yong; Moser, Julia; Yacoub, Essa; Nelson, Steven M.; Vizioli, Luca; Fair, Damien A.; Lenze, Eric J.; Carhart-Harris, Robin; Raison, Charles L.; Raichle, Marcus E.; Snyder, Abraham Z.; Nicol, Ginger E.; Dosenbach, Nico U. F.
作者单位：Washington University (WUSTL); Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Washington University (WUSTL); Washington University (WUSTL); State University System of Florida; Florida State University; Washington University (WUSTL); University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of California System; University of California San Francisco; Imperial College London; University of Wisconsin System; University of Wisconsin Madison; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：A single dose of psilocybin, a psychedelic that acutely causes distortions of space-time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials(1-4). In animal models, psilocybin induces neuroplasticity in cortex and hippocampus(5-8). It remains unclear how human brain network changes relate to subjective and lasting effects of psychedelics. Here we tracked individual-specific brain changes with longitudinal precision functional mapping (roug...
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作者：Tollefson, Jeff
摘要：Virginia Burkett has filed a whistle-blower complaint, asking for an investigation and better policies to protect scientists against political interference.
