2024

最新文章

• Boost French research through academic freedom AI翻译
  作者：Musselin, Christine
  作者单位：Centre National de la Recherche Scientifique (CNRS)
• Picturing the Mind AI翻译
  作者：Noble, Denis
  作者单位：University of Oxford
• SCIENTISTS EDIT THE GENES OF GUT BACTERIA IN LIVING MICE AI翻译
  作者：Conroy, Gemma
• Scientists need more time to think AI翻译
  作者：[Anonymous]
  摘要：E-mails and instant messaging are core to research - but also a distraction. Researchers should study their impact on science, and how they can claw back time to concentrate.
• The Tangle of Science AI翻译
  作者：Aganaba, Timiebi
  作者单位：Arizona State University; Arizona State University-Tempe
• An engineered enzyme embedded into PLA to make self-biodegradable plastic AI翻译
  作者：Guicherd, M.; Ben Khaled, M.; Gueroult, M.; Nomme, J.; Dalibey, M.; Grimaud, F.; Alvarez, P.; Kamionka, E.; Gavalda, S.; Noel, M.; Vuillemin, M.; Amillastre, E.; Labourdette, D.; Cioci, G.; Tournier, V.; Kitpreechavanich, V.; Dubois, P.; Andre, I.; Duquesne, S.; Marty, A.
  作者单位：INRAE; Centre National de la Recherche Scientifique (CNRS); Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; Institut National des Sciences Appliquees de Toulouse; Kasetsart University; University of Mons
  摘要：Plastic production reached 400 million tons in 2022 (ref. 1), with packaging and single-use plastics accounting for a substantial amount of this(2). The resulting waste ends up in landfills, incineration or the environment, contributing to environmental pollution(3). Shifting to biodegradable and compostable plastics is increasingly being considered as an efficient waste-management alternative(4). Although polylactide (PLA) is the most widely used biosourced polymer(5), its biodegradation rate...
• FIRST FOSSIL CHROMOSOMES FOUND IN MAMMOTH SKIN AI翻译
  作者：Guglielmi, Giorgia
• LONG COVID LUNG DAMAGE LINKED TO IMMUNE RESPONSE AI翻译
  作者：Kudiabor, Helena
• CryoET of β-amyloid and tau within postmortem Alzheimer's disease brain AI翻译
  作者：Gilbert, Madeleine A. G.; Fatima, Nayab; Jenkins, Joshua; O'Sullivan, Thomas J.; Schertel, Andreas; Halfon, Yehuda; Wilkinson, Martin; Morrema, Tjado H. J.; Geibel, Mirjam; Read, Randy J.; Ranson, Neil A.; Radford, Sheena E.; Hoozemans, Jeroen J. M.; Frank, Rene A. W.
  作者单位：University of Leeds; University of Leeds; Carl Zeiss AG; University of Leeds; University of Amsterdam; University of Cambridge
  摘要：A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures(1). In Alzheimer's disease, this is characterized by the deposition of beta-amyloid and tau with disease-specific conformations. The in situ structure of amyloid in the human brain is unknown. Here, using cryo-fluorescence microscopy-targeted cryo-sectioning, cryo-focused ion beam-scanning electron microscopy lift-out and cryo-electron tomography, we...
• A eukaryotic-like ubiquitination system in bacterial antiviral defence AI翻译
  作者：Chambers, Lydia R.; Ye, Qiaozhen; Cai, Jiaxi; Gong, Minheng; Ledvina, Hannah E.; Zhou, Huilin; Whiteley, Aaron T.; Suhandynata, Raymond T.; Corbett, Kevin D.
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of Colorado System; University of Colorado Boulder; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Ubiquitination pathways have crucial roles in protein homeostasis, signalling and innate immunity(1-3). In these pathways, an enzymatic cascade of E1, E2 and E3 proteins conjugates ubiquitin or a ubiquitin-like protein (Ubl) to target-protein lysine residues(4). Bacteria encode ancient relatives of E1 and Ubl proteins involved in sulfur metabolism(5,6), but these proteins do not mediate Ubl-target conjugation, leaving open the question of whether bacteria can perform ubiquitination-like protei...