2024

最新文章

• Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain AI翻译
  作者：Kefauver, Jennifer M.; Hakala, Markku; Zou, Luoming; Alba, Josephine; Espadas, Javier; Tettamanti, Maria G.; Gajic, Jelena; Gabus, Caroline; Campomanes, Pablo; Estrozi, Leandro F.; Sen, Nesli E.; Vanni, Stefano; Roux, Aurelien; Desfosses, Ambroise; Loewith, Robbie
  作者单位：University of Geneva; University of Geneva; University of Fribourg; University of Geneva; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); University of Fribourg; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Investigacion en Nanomateriales y Nanotecnologia (CINN)
  摘要：Biological membranes are partitioned into functional zones termed membrane microdomains, which contain specific lipids and proteins1-3. The composition and organization of membrane microdomains remain controversial because few techniques are available that allow the visualization of lipids in situ without disrupting their native behaviour3,4. The yeast eisosome, composed of the BAR-domain proteins Pil1 and Lsp1 (hereafter, Pil1/Lsp1), scaffolds a membrane compartment that senses and responds t...
• Dissociable hindbrain GLP1R circuits for satiety and aversion AI翻译
  作者：Huang, Kuei-Pin; Acosta, Alisha A.; Ghidewon, Misgana Y.; Mcknight, Aaron D.; Almeida, Milena S.; Nyema, Nathaniel T.; Hanchak, Nicholas D.; Patel, Nisha; Gbenou, Yenoukoume S. K.; Adriaenssens, Alice E.; Bolding, Kevin A.; Alhadeff, Amber L.
  作者单位：Monell Chemical Senses Center; University of Pennsylvania; University of London; University College London
  摘要：The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R) agonists, cause aversive responses such as nausea and vomiting1,2, effects that may contribute to their efficacy. Here, we investigated the brain circuits that link satiety to aversion, and unexpectedly discovered that the neural circuits mediating these effects are functionally separable. Systematic investigation across drug-accessible GLP1R populations revealed that only hindbrain neurons are required for the ...
• Your nose has its own army of immune cells - here's how it protects you AI翻译
  作者：Kozlov, Max
  摘要：Detailed profile of the immune cells in the upper airway could help to improve nasal vaccines.
• Never underestimate RNA: how a molecule went from bit player to star of the show AI翻译
  作者：Mattick, John
  作者单位：University of New South Wales Sydney
  摘要：An insider's story of the discoveries that revealed the dazzling abilities of RNA, and the therapeutic possibilities that emerged.
• In vivo interaction screening reveals liver-derived constraints to metastasis AI翻译
  作者：Borrelli, Costanza; Roberts, Morgan; Eletto, Davide; Hussherr, Marie-Didiee; Fazilaty, Hassan; Valenta, Tomas; Lafzi, Atefeh; Kretz, Jonas A.; Vinzoni, Elena Guido; Karakatsani, Andromachi; Adivarahan, Srivathsan; Mannhart, Ardian; Kimura, Shoichiro; Meijs, Ab; Mhamedi, Farah Baccouche; Acar, Ilhan E.; Handler, Kristina; Ficht, Xenia; Platt, Randall J.; Piscuoglio, Salvatore; Moor, Andreas E.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; University of Basel
  摘要：It is estimated that only 0.02% of disseminated tumour cells are able to seed overt metastases1. While this suggests the presence of environmental constraints to metastatic seeding, the landscape of host factors controlling this process remains largely unclear. Here, combining transposon technology2 and fluorescence niche labelling3, we developed an in vivo CRISPR activation screen to systematically investigate the interactions between hepatocytes and metastatic cells. We identify plexin B2 as...
• peri-Fused polyaromatic molecular contacts for perovskite solar cells AI翻译
  作者：Zhao, Ke; Liu, Qingqing; Yao, Libing; Deger, Caner; Shen, Jiahui; Zhang, Xu; Shi, Pengju; Tian, Yuan; Luo, Yixin; Xu, Jiazhe; Zhou, Jingjing; Jin, Donger; Wang, Sisi; Fan, Wei; Zhang, Shaochen; Chu, Shenglong; Wang, Xiaonan; Tian, Liuwen; Liu, Ruzhang; Zhang, Li; Yavuz, Ilhan; Wang, Hong-fei; Yang, Deren; Wang, Rui; Xue, Jingjing
  作者单位：Zhejiang University; Zhejiang University; Westlake University; Westlake University; Marmara University; Yangzhou University; Westlake University; Baima Lake Laboratory; Westlake University; Westlake University; Westlake University
  摘要：Molecule-based selective contacts have become a crucial component to ensure high-efficiency inverted perovskite solar cells1-5. These molecules always consist of a conjugated core with heteroatom substitution to render the desirable carrier-transport capability6-9. So far, the design of successful conjugation cores has been limited to two N-substituted pi-conjugated structures, carbazole and triphenylamine, with molecular optimization evolving around their derivatives2,5,10-12. However, furthe...
• Highest ocean heat in four centuries places Great Barrier Reef in danger AI翻译
  作者：Henley, Benjamin J.; McGregor, Helen V.; King, Andrew D.; Hoegh-Guldberg, Ove; Arzey, Ariella K.; Karoly, David J.; Lough, Janice M.; DeCarlo, Thomas M.; Linsley, Braddock K.
  作者单位：University of Wollongong; University of Wollongong; University of Melbourne; University of Melbourne; University of Melbourne; University of Queensland; Australian Institute of Marine Science; University of Western Australia; University of Western Australia; Tulane University; Columbia University
  摘要：Mass coral bleaching on the Great Barrier Reef (GBR) in Australia between 2016 and 2024 was driven by high sea surface temperatures (SST)1. The likelihood of temperature-induced bleaching is a key determinant for the future threat status of the GBR2, but the long-term context of recent temperatures in the region is unclear. Here we show that the January-March Coral Sea heat extremes in 2024, 2017 and 2020 (in order of descending mean SST anomalies) were the warmest in 400 years, exceeding the ...
• Seventh patient 'cured' of HIV: why scientists are excited AI翻译
  作者：Mallapaty, Smriti
  摘要：A man in Germany is HIV-free after receiving stem cells that are not resistant to the virus.
• Genetic continuity and change among the Indigenous peoples of California (vol 624, pg 122, 2023) AI翻译
  作者：Nakatsuka, Nathan; Holguin, Brian; Sedig, Jakob; Langenwalter, Paul E.; Carpenter, John; Culleton, Brendan J.; Garcia-Moreno, Cristina; Harper, Thomas K.; Martin, Debra; Martinez-Ramirez, Jupiter; Porcayo-Michelini, Antonio; Tiesler, Vera; Villapando-Canchola, M. Elisa; Valdes Herrera, Alejandro; Callan, Kim; Curtis, Elizabeth; Kearns, Aisling; Iliev, Lora; Lawson, Ann Marie; Mah, Matthew; Mallick, Swapan; Micco, Adam; Michel, Megan; Workman, J. Noah; Oppenheimer, Jonas; Qiu, Lijun; Zalzala, Fatma; Rohland, Nadin; Diaz, Jose Luis Punzo; Johnson, John R.; Reich, David
  作者单位：Harvard University; Harvard Medical School; Harvard University; University of California System; University of California Santa Barbara; Harvard University; Biola University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Universidad Autonoma de Yucatan; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
• Mechanisms of actin filament severing and elongation by formins AI翻译
  作者：Palmer, Nicholas J.; Barrie, Kyle R.; Dominguez, Roberto
  作者单位：University of Pennsylvania; University of Pennsylvania
  摘要：Humans express 15 formins that play crucial roles in actin-based processes, including cytokinesis, cell motility and mechanotransduction1,2. However, the lack of structures bound to the actin filament (F-actin) has been a major impediment to understanding formin function. Whereas formins are known for their ability to nucleate and elongate F-actin3-7, some formins can additionally depolymerize, sever or bundle F-actin. Two mammalian formins, inverted formin 2 (INF2) and diaphanous 1 (DIA1, enc...