2024

最新文章

• An enterococcal phage-derived enzyme suppresses graft-versus-host disease AI翻译
  作者：Fujimoto, Kosuke; Hayashi, Tetsuya; Yamamoto, Mako; Sato, Noriaki; Shimohigoshi, Masaki; Miyaoka, Daichi; Yokota, Chieko; Watanabe, Miki; Hisaki, Yuki; Kamei, Yukari; Yokoyama, Yuki; Yabuno, Takato; Hirose, Asao; Nakamae, Mika; Nakamae, Hirohisa; Uematsu, Miho; Sato, Shintaro; Yamaguchi, Kiyoshi; Furukawa, Yoichi; Akeda, Yukihiro; Hino, Masayuki; Imoto, Seiya; Uematsu, Satoshi
  作者单位：Osaka Metropolitan University; University of Tokyo; Osaka Metropolitan University; University of Tokyo; Osaka Metropolitan University; Wakayama Medical University; University of Tokyo; Japan Institute for Health Security (JIHS); National Institute of Infectious Diseases (NIID); University of Tokyo; Osaka Metropolitan University; Osaka Metropolitan University
  摘要：Changes in the gut microbiome have pivotal roles in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogenic haematopoietic cell transplantation (allo-HCT)(1-6). However, effective methods for safely resolving gut dysbiosis have not yet been established. An expansion of the pathogen Enterococcus faecalis in the intestine, associated with dysbiosis, has been shown to be a risk factor for aGVHD(7-10). Here we analyse the intestinal microbiome of patients with allo-HCT, and fin...
• Cheap light sources could make AI more energy efficient AI翻译
  作者：Luedge, Kathy; Jaurigue, Lina
  作者单位：Technische Universitat Ilmenau
  摘要：Light-based devices can reduce the energy consumption of computers, but most rely on lasers, which are expensive to integrate with other technologies. An approach that uses LEDs instead of lasers provides a path forwards.
• Guidelines on lab-grown embryo models are strong enough to meet ethical standards - and will build trust in science AI翻译
  作者：Sturmey, Roger
  作者单位：University of York - UK; University of Hull
  摘要：The UK code of practice for researchers working with stem-cell-based embryo models is designed to both reassure the public and provide valuable guidance to researchers.
• Three ways AI is changing the 2024 Olympics for athletes and fans AI翻译
  作者：Kulkarni, Sumeet
  摘要：From training to broadcasting, artificial intelligence will have an imprint on this year's event for the first time.
• Sources of gene expression variation in a globally diverse human cohort AI翻译
  作者：Taylor, Dylan J.; Chhetri, Surya B.; Tassia, Michael G.; Biddanda, Arjun; Yan, Stephanie M.; Wojcik, Genevieve L.; Battle, Alexis; McCoy, Rajiv C.
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
  摘要：Genetic variation that influences gene expression and splicing is a key source of phenotypic diversity1-5. Although invaluable, studies investigating these links in humans have been strongly biased towards participants of European ancestries, which constrains generalizability and hinders evolutionary research. Here to address these limitations, we developed MAGE, an open-access RNA sequencing dataset of lymphoblastoid cell lines from 731 individuals from the 1000 Genomes Project6, spread acros...
• Molecular mechanism of ligand gating and opening of NMDA receptor AI翻译
  作者：Chou, Tsung-Han; Epstein, Max; Fritzemeier, Russell G.; Akins, Nicholas S.; Paladugu, Srinu; Ullman, Elijah Z.; Liotta, Dennis C.; Traynelis, Stephen F.; Furukawa, Hiro
  作者单位：Cold Spring Harbor Laboratory; Emory University; Emory University; Emory University
  摘要：Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental means by which neurons control their excitability and neuroplasticity1. The N-methyl-d-aspartate receptor (NMDAR) is unique among all ligand-gated channels, requiring two ligands-glutamate and glycine-for activation. These receptors function as heterotetrameric ion channels, with the channel opening dependent on the simultaneous binding of glycine and glutamate to the extracellular ligand-binding domain...
• Wasted renewables deny households cheap energy AI翻译
  作者：Foteinis, Spyros
  作者单位：Heriot Watt University
• Are our rock-climbing shoes shedding plastics? AI翻译
  作者：Gewin, Virginia; Sherman, Anya
  作者单位：University of Vienna
  摘要：Environmental scientist Anya Sherman studies how microplastics can be taken up by crops and people.
• How to improve assessments of publication integrity AI翻译
  作者：Grey, Andrew; Avenell, Alison; Klein, Andrew A.; Byrne, Jennifer A.; Wilmshurst, Peter; Bolland, Mark J.
  作者单位：University of Auckland; University of Aberdeen; Papworth Hospital; University of Sydney
  摘要：Too often, journal assessments of potentially unreliable research are superficial, opaque and prolonged. Changes to the guidance given by the Committee on Publication Ethics could tighten up the process.
• THE 'PHD INFLUENCERS' AI翻译
  作者：Wong, Carissa