8045期

最新文章

• Delivering protection against a pregnancy illness AI翻译
  作者：Thadhani, Ravi; Karumanchi, S. Ananth
  作者单位：Emory University; Cedars Sinai Medical Center
• Researchers: concentrate on bread-and-butter issues to get political buy-in AI翻译
  作者：Manning, Preston
• Giant study finds untrustworthy trials pollute gold-standard medical reviews AI翻译
  作者：Van Noorden, Richard
• Reinventing type 2 immunity in cancer AI翻译
  作者：Wagner, Marek; Nishikawa, Hiroyoshi; Koyasu, Shigeo
  作者单位：Nagoya University; National Cancer Center - Japan; RIKEN
  摘要：Our understanding of type 2 immunity has undergone a substantial transformation in recent years, revealing previously unknown functions. Beyond its canonical role in defence against parasitic helminth infections, type 2 immunity safeguards the host through additional mechanisms, including the suppression of excessive type 1 immune responses, regulation of tissue repair and maintenance of adipose tissue homeostasis. However, unlike type 1 immune responses, type 2 immunity is perceived as a pote...
• 'One of the last taboos': breaking the stigma of substance-use disorders in academia AI翻译
  作者：Wild, Sarah
• The global H5N1 influenza panzootic in mammals AI翻译
  作者：Peacock, Thomas P.; Moncla, Louise; Dudas, Gytis; VanInsberghe, David; Sukhova, Ksenia; Lloyd-Smith, James O.; Worobey, Michael; Lowen, Anice C.; Nelson, Martha I.
  作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Pirbright Institute; Imperial College London; University of Pennsylvania; Vilnius University; Emory University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of Arizona; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
  摘要：Influenza A viruses have caused more documented global pandemics in human history than any other pathogen(1,2). High pathogenicity avian influenza viruses belonging to the H5N1 subtype are a leading pandemic risk. Two decades after H5N1 'bird flu' became established in poultry in Southeast Asia, its descendants have resurged(3), setting off a H5N1 panzootic in wild birds that is fuelled by: (1) rapid intercontinental spread, reaching South America and Antarctica for the first time(4,5); (2) fa...
• Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD AI翻译
  作者：Garcia-Cabau, Carla; Bartomeu, Anna; Tesei, Giulio; Cheung, Kai Chit; Pose-Utrilla, Julia; Pico, Sara; Balaceanu, Andreea; Duran-Arque, Berta; Fernandez-Alfara, Marcos; Martin, Judit; De Pace, Cesare; Ruiz-Perez, Lorena; Garcia, Jesus; Battaglia, Giuseppe; Lucas, Jose J.; Hervas, Ruben; Lindorff-Larsen, Kresten; Mendez, Raul; Salvatella, Xavier
  作者单位：Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; University of Copenhagen; University of Hong Kong; Autonomous University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); Instituto de Salud Carlos III; University of London; University College London; University of London; University College London; Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; University of Barcelona; University of Barcelona; ICREA
  摘要：The inclusion of microexons by alternative splicing occurs frequently in neuronal proteins. The roles of these sequences are largely unknown, and changes in their degree of inclusion are associated with neurodevelopmental disorders(1). We have previously shown that decreased inclusion of a 24-nucleotide neuron-specific microexon in CPEB4, a RNA-binding protein that regulates translation through cytoplasmic changes in poly(A) tail length, is linked to idiopathic autism spectrum disorder (ASD)(2...
• Who built Europe's first cities? Clues about the urban revolution emerge AI翻译
  作者：Marris, Emma
• Self-organized patterning of crocodile head scales by compressive folding AI翻译
  作者：Santos-Duran, Gabriel N.; Cooper, Rory L.; Jahanbakhsh, Ebrahim; Timin, Grigorii; Milinkovitch, Michel C.
  作者单位：University of Geneva; Swiss Institute of Bioinformatics
  摘要：Amniote integumentary appendages constitute a diverse group of micro-organs, including feathers, hair and scales. These structures typically develop as genetically controlled units(1), the spatial patterning of which emerges from a self-organized chemical Turing system(2,3) with integrated mechanical feedback(4,5). The seemingly purely mechanical patterning of polygonal crocodile head scales provides an exception to this paradigm(6). However, the nature and origin of the mechanical stress fiel...
• Nonlinear receptive fields evoke redundant retinal coding of natural scenes AI翻译
  作者：Karamanlis, Dimokratis; Khani, Mohammad H.; Schreyer, Helene M.; Zapp, Soeren J.; Mietsch, Matthias; Gollisch, Tim
  作者单位：University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Leibniz Association; Deutsches Primatenzentrum (DPZ); German Centre for Cardiovascular Research; University of Gottingen; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Geneva
  摘要：The role of the vertebrate retina in early vision is generally described by the efficient coding hypothesis(1,2), which predicts that the retina reduces the redundancy inherent in natural scenes(3) by discarding spatiotemporal correlations while preserving stimulus information(4). It is unclear, however, whether the predicted decorrelation and redundancy reduction in the activity of ganglion cells, the retina's output neurons, hold under gaze shifts, which dominate the dynamics of the natural ...