8045期

最新文章

• We need to talk about human genome editing AI翻译
  作者：[Anonymous]
  摘要：In a few decades, gene-editing technologies could reduce the likelihood of common human diseases. Societies must use this time to prepare for their arrival. In a few decades, gene-editing technologies could reduce the likelihood of common human diseases. Societies must use this time to prepare for their arrival.
• The skin's 'surprise' power: it has its very own immune system AI翻译
  作者：Guglielmi, Giorgia
• Electrochemical synthesis goes wireless AI翻译
  作者：O'Brien, Thomas M.; Lennox, Alastair J. J.
  作者单位：University of Bristol
• What do people eat and why do they eat it? AI翻译
  作者：O'Brien, Thomas M.; Lennox, Alastair J. J.
  作者单位：University of Bristol
  摘要：A 1975 report sparks a debate about the place of sociology in human nutrition research, and a crystal-clear lecture on chemical morphology, in our weekly dip into Nature's archive. Snippets from Nature's past.
• Tracking transcription-translation coupling in real time AI翻译
  作者：Qureshi, Nusrat Shahin; Duss, Olivier
  作者单位：European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL)
  摘要：A central question in biology is how macromolecular machines function cooperatively. In bacteria, transcription and translation occur in the same cellular compartment, and can be physically and functionally coupled1-4. Although high-resolution structures of the ribosome-RNA polymerase (RNAP) complex have provided initial mechanistic insights into the coupling process5-10, we lack knowledge of how these structural snapshots are placed along a dynamic reaction trajectory. Here we reconstitute a ...
• HRG-9 homologues regulate haem trafficking from haem-enriched compartments (vol 610, pg 768, 2022) AI翻译
  作者：Sun, Fengxiu; Zhao, Zhenzhen; Willoughby, Mathilda M.; Shen, Shuaiqi; Zhou, Yu; Shao, Yiyan; Kang, Jing; Chen, Yongtian; Chen, Mengying; Yuan, Xiaojing; Hamza, Iqbal; Reddi, Amit R.; Chen, Caiyong
• How to ensure only dying cells rupture AI翻译
  作者：Bernard, Elliott M.; Broz, Petr
  作者单位：University of Lausanne
• Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture AI翻译
  作者：Pourmal, Sergei; Truong, Melissa E.; Johnson, Matthew C.; Yang, Ying; Zhou, Lijuan; Alegre, Kamela; Stowe, Irma B.; Gupta, Shalini; Chen, Phoebe A.; Zhang, Yingnan; Rohou, Alexis; Newton, Kim; Kayagaki, Nobuhiko; Dixit, Vishva M.; Deshpande, Ishan
  作者单位：Roche Holding; Roche Holding USA; Genentech; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Genentech; Roche Holding USA
  摘要：Lytic cell death culminates in plasma membrane rupture, which releases large intracellular molecules to augment the inflammatory response. Plasma membrane rupture is mediated by the effector membrane protein ninjurin-1 (NINJ1)(1), which polymerizes and ruptures the membrane via its hydrophilic face(1-4). How NINJ1 is restrained under steady-state conditions to ensure cell survival remains unknown. Here we describe the molecular underpinnings of NINJ1 inhibition. Using cryogenic electron micros...
• Lipid-delivery system could treat life-threatening pregnancy complication AI翻译
  作者：Thadhani, Ravi; Karumanchi, S. Ananth
  作者单位：Emory University; Cedars Sinai Medical Center
  摘要：Pre-eclampsia is a common and dangerous pregnancy-related illness. Using tiny lipid particles to deliver messenger RNA directly to the placenta to boost blood-vessel function might prove to be an effective treatment. Testing lipid nanoparticles for pre-eclampsia treatment.
• Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation AI翻译
  作者：Chen, Jie; Ou, Yuhui; Liu, Ying
  作者单位：Peking University; Tsinghua University