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作者：[Anonymous]
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作者：[Anonymous]
摘要：A century ago, physics had its Darwinian moment - a change in perspective that was as consequential for the physical sciences as the theory of evolution by natural selection was for biology. A century ago, physics had its Darwinian moment - a change in perspective that was as consequential for the physical sciences as the theory of evolution by natural selection was for biology.
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Williamson, Michael R.; Kwon, Wookbong; Woo, Junsung; Ko, Yeunjung; Maleki, Ehson; Yu, Kwanha; Murali, Sanjana; Sardar, Debosmita; Deneen, Benjamin
作者单位：Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine
摘要：The physical manifestations of memory formation and recall are fundamental questions that remain unresolved(1). At the cellular level, ensembles of neurons called engrams are activated by learning events and control memory recall(1-5). Astrocytes are found in close proximity to neurons and engage in a range of activities that support neurotransmission and circuit plasticity(6-10). Moreover, astrocytes exhibit experience-dependent plasticity(11-13), although whether specific ensembles of astroc...
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作者：Camilleri, Kristian
作者单位：University of Melbourne
摘要：It began with concerns about the orbits used to explain the motion of electrons in atoms - but quantum theory ended up upending reality itself. It began with concerns about the orbits used to explain the motion of electrons in atoms - but quantum theory ended up upending reality itself.
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作者：Gu, Li; Zhu, Yahui; Nandi, Shuvro P.; Lee, Maiya; Watari, Kosuke; Bareng, Breanna; Ohira, Masafumi; Liu, Yuxiao; Sakane, Sadatsugu; Carlessi, Rodrigo; Sauceda, Consuelo; Dhar, Debanjan; Ganguly, Souradipta; Hosseini, Mojgan; Teneche, Marcos G.; Adams, Peter D.; Gonzalez, David J.; Kisseleva, Tatiana; Tirnitz-Parker, Janina E. E.; Simon, M. Celeste; Alexandrov, Ludmil B.; Karin, Michael
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Sichuan University; Sichuan University; Chongqing University; Sichuan University; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Curtin University; University of Western Australia; Harry Perkins Institute of Medical Research; Queen Elizabeth II Medical Centre; University of Western Australia; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Sanford Burnham Prebys Medical Discovery Institute; University of Pennsylvania; University of Pennsylvania
摘要：Hepatocellular carcinoma (HCC) originates from differentiated hepatocytes undergoing compensatory proliferation in livers damaged by viruses or metabolic-dysfunction-associated steatohepatitis (MASH)(1). While increasing HCC risk(2), MASH triggers p53-dependent hepatocyte senescence(3), which we found to parallel hypernutrition-induced DNA breaks. How this tumour-suppressive response is bypassed to license oncogenic mutagenesis and enable HCC evolution was previously unclear. Here we identifie...
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作者：Miao, Jianwei
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：Microscopy and crystallography are two essential experimental methodologies for advancing modern science. They complement one another, with microscopy typically relying on lenses to image the local structures of samples, and crystallography using diffraction to determine the global atomic structure of crystals. Over the past two decades, computational microscopy, encompassing coherent diffractive imaging (CDI) and ptychography, has advanced rapidly, unifying microscopy and crystallography to o...
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作者：Chen, Mengying; Su, Qiang; Shi, Yigong
作者单位：Westlake University; Westlake Laboratory; Tsinghua University; Shenzhen Medical Academy of Research & Translation (SMART)
摘要：Allergic diseases affect more than a quarter of individuals in industrialized countries, and are a major public health concern(1,2). The high-affinity Fc receptor for immunoglobulin E (Fc epsilon RI), which is mainly present on mast cells and basophils, has a crucial role in allergic diseases(3-5). Monomeric immunoglobulin E (IgE) binding to Fc epsilon RI regulates mast cell survival, differentiation and maturation(6-8). However, the underlying molecular mechanism remains unclear. Here we demo...
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作者：Nowogrodzki, Julian
