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作者：Hollmann, Noah; Mueller, Samuel; Purucker, Lennart; Krishnakumar, Arjun; Koerfer, Max; Bin Hoo, Shi; Schirrmeister, Robin Tibor; Hutter, Frank
作者单位：University of Freiburg; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; University of Freiburg; University of Freiburg
摘要：Tabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science(1,2). The fundamental prediction task of filling in missing values of a label column based on the rest of the columns is essential for various applications as diverse as biomedical risk models, drug discovery and materials science. Although deep learning has revolutionized learning from raw data and led to numerous high-profile...
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作者：He, Zhisong; Dony, Leander; Fleck, Jonas Simon; Szalata, Artur; Li, Katelyn X.; Sliskovic, Irena; Lin, Hsiu-Chuan; Santel, Malgorzata; Atamian, Alexander; Quadrato, Giorgia; Sun, Jieran; Pasca, Sergiu P.; Camp, J. Gray; Theis, Fabian J.; Treutlein, Barbara
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作者：Chen-Liaw, Alice; Aggarwala, Varun; Mogno, Ilaria; Haifer, Craig; Li, Zhihua; Eggers, Joseph; Helmus, Drew; Hart, Amy; Wehkamp, Jan; Lamouse-Smith, Esi S. N.; Kerby, Robert L.; Rey, Federico E.; Colombel, Jean Frederic; Kamm, Michael A.; Olle, Bernat; Norman, Jason M.; Menon, Rajita; Watson, Andrea R.; Crossett, Emily; Terveer, Elisabeth M.; Keller, Josbert J.; Borody, Thomas J.; Grinspan, Ari; Paramsothy, Sudarshan; Kaakoush, Nadeem O.; Dubinsky, Marla C.; Faith, Jeremiah J.
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Sydney; University of New South Wales Sydney; Icahn School of Medicine at Mount Sinai; Johnson & Johnson; Janssen Pharmaceuticals; University of Wisconsin System; University of Wisconsin Madison; NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Haaglanden Medical Center; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Centre For Digestive Diseases; Macquarie University; University of New South Wales Sydney
摘要：Despite the fundamental role of bacterial strain variation in gut microbiota function(1-6), the number of unique strains of a species that can stably colonize the human intestine is still unknown for almost all species. Here we determine the strain richness (SR) of common gut species using thousands of sequenced bacterial isolates with paired metagenomes. We show that SR varies across species, is transferable by faecal microbiota transplantation, and is uniquely low in the gut compared with so...
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作者：Ramirez, Sydney I.; Faraji, Farhoud; Hills, L. Benjamin; Lopez, Paul G.; Goodwin, Benjamin; Stacey, Hannah D.; Sutton, Henry J.; Hastie, Kathryn M.; Saphire, Erica Ollmann; Kim, Hyun Jik; Mashoof, Sara; Yan, Carol H.; DeConde, Adam S.; Levi, Gina; Crotty, Shane
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作者：Foy, Brody H.; Petherbridge, Rachel; Roth, Maxwell T.; Zhang, Cindy; De Souza, Daniel C.; Mow, Christopher; Patel, Hasmukh R.; Patel, Chhaya H.; Ho, Samantha N.; Lam, Evie; Powe, Camille E.; Hasserjian, Robert P.; Karczewski, Konrad J.; Tozzo, Veronica; Higgins, John M.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of Washington; University of Washington Seattle; Adventist Health Services; AdventHealth; Mass General Brigham; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：The complete blood count (CBC) is an important screening tool for healthy adults and a common test at periodic exams. However, results are usually interpreted relative to one-size-fits-all reference intervals(1,2), undermining the precision medicine goal to tailor care for patients on the basis of their unique characteristics(3,4). Here we study thousands of diverse patients at an academic medical centre and show that routine CBC indices fluctuate around stable values or setpoints(5), and setp...
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作者：Bhardwaj, Abhishek; Panepinto, Maria C.; Ueberheide, Beatrix; Neel, Benjamin G.
作者单位：New York University; NYU Langone Medical Center; New York University; New York University; New York University
摘要：Hypoxic cancer cells resist many antineoplastic therapies and can seed recurrence(1,2). We previously found that either deficiency or inhibition of protein-tyrosine phosphatase (PTP1B) promotes human epidermal growth factor receptor 2-positive breast cancer cell death in hypoxia by activation of RNF213 (ref. 3), a large protein with multiple AAA-ATPase domains and two ubiquitin ligase domains (RING and RZ) implicated in Moyamoya disease, lipotoxicity and innate immunity(4). Here we report that...
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作者：Muindi, Fanuel
作者单位：Northeastern University
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作者：Nowogrodzki, Julian
摘要：Studies reveal how risky play can benefit child development. But encouraging it can be a challenge for parents. Studies reveal how risky play can benefit child development. But encouraging it can be a challenge for parents.
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作者：McElfresh, Duncan C.
作者单位：Stanford University; Stanford Medicine
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作者：[Anonymous]
