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作者:Burke, Katie L.
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作者:Prywes, Noam; Phillips, Naiya R.; Oltrogge, Luke M.; Lindner, Sebastian; Taylor-Kearney, Leah J.; Tsai, Yi-Chin Candace; de Pins, Benoit; Cowan, Aidan E.; Chang, Hana A.; Wang, Renee Z.; Hall, Laina N.; Bellieny-Rabelo, Daniel; Nisonoff, Hunter M.; Weissman, Rachel F.; Flamholz, Avi I.; Ding, David; Bhatt, Abhishek Y.; Mueller-Cajar, Oliver; Shih, Patrick M.; Milo, Ron; Savage, David F.
作者单位:University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; Ruprecht Karls University Heidelberg; University of California System; University of California Berkeley; Nanyang Technological University; University of Naples Federico II; United States Department of Energy (DOE); Joint BioEnergy Institute - JBEI; Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; California Institute of Technology; University of California System; University of California San Diego; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Joint BioEnergy Institute - JBEI; Weizmann Institute of Science
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作者:Amisaki, Masataka; Zebboudj, Abderezak; Yano, Hiroshi; Zhang, Siqi Linsey; Payne, George; Chandra, Adrienne Kaya; Yu, Rebecca; Guasp, Pablo; Sethna, Zachary M.; Ohmoto, Akihiro; Rojas, Luis A.; Cheng, Charlotte; Waters, Theresa; Solovyov, Alexander; Martis, Stephen; Doane, Ashley S.; Reiche, Charlotte; Bruno, Emmanuel M.; Milighetti, Martina; Soares, Kevin; Odgerel, Zagaa; Moral, John Alec; Zhao, Julia N.; Gonen, Mithat; Gardner, Rui; Tumanov, Alexei V.; Khan, Abdul G.; Vergnolle, Olivia; Nyakatura, Elisabeth K.; Lorenz, Ivo C.; Baca, Manuel; Patterson, Erin; Greenbaum, Benjamin; Artis, David; Merghoub, Taha; Balachandran, Vinod P.
作者单位:Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of Texas System; University of Texas at San Antonio; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
摘要:Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LT beta receptor (LT beta R) pathway1, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues2, induces TLSs. In mice, Il33 deficiency severely attenua...
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作者:Sowemimo, Annabel
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作者:Moon, Donghoon; Lee, Wonsik; Lim, Chaesung; Kim, Jinwoo; Kim, Jiwoo; Jung, Yeonjoon; Choi, Hyun-Young; Choi, Won Seok; Kim, Hangyel; Baek, Ji-Hwan; Kim, Changheon; Joo, Jaewoong; Oh, Hyun-Geun; Jang, Hajung; Watanabe, Kenji; Taniguchi, Takashi; Bae, Sukang; Son, Jangyup; Ryu, Huije; Kwon, Junyoung; Cheong, Hyeonsik; Han, Jeong Woo; Jang, Hyejin; Lee, Gwan-Hyoung
作者单位:Seoul National University (SNU); Seoul National University (SNU); Korea Institute of Science & Technology (KIST); Sogang University; National Institute for Materials Science; National Institute for Materials Science; Jeonbuk National University; Korea Institute of Science & Technology (KIST); University of Science & Technology (UST); Samsung; Samsung Electronics
摘要:Two-dimensional (2D) semiconductors, particularly transition metal dichalcogenides (TMDs), are promising for advanced electronics beyond silicon1, 2-3. Traditionally, TMDs are epitaxially grown on crystalline substrates by chemical vapour deposition. However, this approach requires post-growth transfer to target substrates, which makes controlling thickness and scalability difficult. Here we introduce a method called hypotaxy ('hypo' meaning downward and 'taxy' meaning arrangement), which enab...
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作者:Rad, H. Aghaee; Ainsworth, T.; Alexander, R. N.; Altieri, B.; Askarani, M. F.; Baby, R.; Banchi, L.; Baragiola, B. Q.; Bourassa, J. E.; Chadwick, R. S.; Charania, I.; Chen, H.; Collins, M. J.; Contu, P.; D'Arcy, N.; Dauphinais, G.; De Prins, R.; Deschenes, D.; Di Luch, I.; Duque, S.; Edke, P.; Fayer, S. E.; Ferracin, S.; Ferretti, H.; Gefaell, J.; Glancy, S.; Gonzalez-Arciniegas, C.; Grainge, T.; Han, Z.; Hastrup, J.; Helt, L. G.; Hillmann, T.; Hundal, J.; Izumi, S.; Jaeken, T.; Jonas, M.; Kocsis, S.; Krasnokutska, I.; Larsen, M. V.; Laskowski, P.; Laudenbach, F.; Lavoie, J.; Li, M.; Lomonte, E.; Lopetegui, C. E.; Luey, B.; Lund, A. P.; Ma, C.; Madsen, L. S.; Mahler, D. H.; Mantilla Calderon, L.; Menotti, M.; Miatto, F. M.; Morrison, B.; Nadkarni, P. J.; Nakamura, T.; Neuhaus, L.; Niu, Z.; Noro, R.; Papirov, K.; Pesah, A.; Phillips, D. S.; Plick, W. N.; Rogalsky, T.; Rortais, F.; Sabines-Chesterking, J.; Safavi-Bayat, S.; Sazhaev, E.; Seymour, M.; Rezaei Shad, K.; Silverman, M.; Srinivasan, S. A.; Stephan, M.; Tang, Q. Y.; Tasker, J. F.; Teo, Y. S.; Then, R. B.; Tremblay, J. E.; Tzitrin, I.; Vaidya, V. D.; Vasmer, M.; Vernon, Z.; Villalobos, L. F. S. S. M.; Walshe, B. W.; Weil, R.; Xin, X.; Yan, X.; Yao, Y.; Zamani Abnili, M.; Zhang, Y.
摘要:Photonics offers a promising platform for quantum computing1, 2, 3-4, owing to the availability of chip integration for mass-manufacturable modules, fibre optics for networking and room-temperature operation of most components. However, experimental demonstrations are needed of complete integrated systems comprising all basic functionalities for universal and fault-tolerant operation5. Here we construct a (sub-performant) scale model of a quantum computer using 35 photonic chips to demonstrate...
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作者:Castelvecchi, Davide
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作者:Du, Zhanwen; Wang, Han; Luo, Shuqi; Yun, Zixi; Wu, Chen; Yang, Wangfei; Buck, Matthias; Zheng, Wenwei; Hansen, Alexandar L.; Kao, Hung-Ying; Yang, Sichun
作者单位:University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Arizona State University; University System of Ohio; Case Western Reserve University; University System of Ohio; Ohio State University
摘要:The oestrogen receptor (ER or ER alpha), a nuclear hormone receptor that drives most breast cancer1, is commonly activated by phosphorylation at serine 118 within its intrinsically disordered N-terminal transactivation domain2,3. Although this modification enables oestrogen-independent ER function, its mechanism has remained unclear despite ongoing clinical trials of kinase inhibitors targeting this region4, 5-6. By integration of small-angle X-ray scattering and nuclear magnetic resonance spe...
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作者:Guo, Tiannan; Steen, Judith A.; Mann, Matthias
作者单位:Westlake University; Westlake Laboratory; Westlake University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Max Planck Society; University of Copenhagen
摘要:Mass-spectrometry (MS)-based proteomics has evolved into a powerful tool for comprehensively analysing biological systems. Recent technological advances have markedly increased sensitivity, enabling single-cell proteomics and spatial profiling of tissues. Simultaneously, improvements in throughput and robustness are facilitating clinical applications. In this Review, we present the latest developments in proteomics technology, including novel sample-preparation methods, advanced instrumentatio...
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作者:[Anonymous]