8052期

最新文章

• Combine AI with citizen science to fight poverty AI翻译
  作者：[Anonymous]
• Mapping cells through time and space with moscot AI翻译
  作者：Klein, Dominik; Palla, Giovanni; Lange, Marius; Klein, Michal; Piran, Zoe; Gander, Manuel; Meng-Papaxanthos, Laetitia; Sterr, Michael; Saber, Lama; Jing, Changying; Bastidas-Ponce, Aimee; Cota, Perla; Tarquis-Medina, Marta; Parikh, Shrey; Gold, Ilan; Lickert, Heiko; Bakhti, Mostafa; Nitzan, Mor; Cuturi, Marco; Theis, Fabian J.
  作者单位：Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Technical University of Munich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Hebrew University of Jerusalem; Alphabet Inc.; DeepMind; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; German Center for Diabetes Research (DZD); Technical University of Munich; University of Munich; Hebrew University of Jerusalem; Hebrew University of Jerusalem
  摘要：Single-cell genomic technologies enable the multimodal profiling of millions of cells across temporal and spatial dimensions. However, experimental limitations hinder the comprehensive measurement of cells under native temporal dynamics and in their native spatial tissue niche. Optimal transport has emerged as a powerful tool to address these constraints and has facilitated the recovery of the original cellular context1, 2, 3-4. Yet, most optimal transport applications are unable to incorporat...
• Sharing benefits of research is key to effective science communication AI翻译
  作者：Zanetta-Colombo, Nicolas C.
  作者单位：Ruprecht Karls University Heidelberg
• Reply to: Causal claims, causal assumptions and protected area impact AI翻译
  作者：Brodie, Jedediah F.; Mohd-Azlan, Jayasilan; Chen, Cheng; Wearn, Oliver R.; Deith, Mairin C. M.; Ball, James G. C.; Slade, Eleanor M.; Burslem, David F. R. P.; Teoh, Shu Woan; Williams, Peter J.; Nguyen, An; Moore, Jonathan H.; Goetz, Scott J.; Burns, Patrick; Jantz, Patrick; Hakkenberg, Christopher R.; Kaszta, Zaneta; Cushman, Sam; Coomes, David; Helmy, Olga E.; Reynolds, Glen; Rodriguez, Jon Paul; Jetz, Walter; Luskin, Matthew Scott
  作者单位：University of Montana System; University of Montana; University of Montana System; University of Montana; University of Malaysia Sarawak; University of British Columbia; University of British Columbia; University of British Columbia; University of Cambridge; University of Cambridge; Nanyang Technological University; University of Aberdeen; Leibniz Institut fur Zoo und Wildtierforschung; Southern University of Science & Technology; University of East Anglia; Northern Arizona University; Northern Arizona University; University of Oxford; Northern Arizona University; Yale University; Yale University; University of Queensland
• Targeting FOXM1 condensates reduces breast tumour growth and metastasis AI翻译
  作者：Xie, Feng; Zhou, Xiaoxue; Ran, Yu; Li, Ran; Zou, Jing; Wan, Shiyun; Su, Peng; Meng, Xuli; Yan, Haiyan; Lu, Huasong; Ru, Heng; Hu, Hai; Mao, Zhengwei; Yang, Bing; Zhou, Fangfang; Zhang, Long
  作者单位：Soochow University - China; Tianfu Jincheng Laboratory; Hangzhou City University; Zhejiang University; Zhejiang University; Hangzhou Medical College; Zhejiang Provincial People's Hospital; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS; Zhejiang Cancer Hospital; Zhejiang University; Nanchang University
  摘要：Identifying phase-separated structures remains challenging, and effective intervention methods are currently lacking1. Here we screened for phase-separated proteins in breast tumour cells and identified forkhead (FKH) box protein M1 (FOXM1) as the most prominent candidate. Oncogenic FOXM1 underwent liquid-liquid phase separation (LLPS) with FKH consensus DNA element, and compartmentalized the transcription apparatus in the nucleus, thereby sustaining chromatin accessibility and super-enhancer ...