8052期

最新文章

• Learned magnetic map cues and two mechanisms of magnetoreception in turtles AI翻译
  作者：Goforth, Kayla M.; Lohmann, Catherine M. F.; Gavin, Andrew; Henning, Reyco; Harvey, Andrew; Hinton, Tara L.; Lim, Dana S.; Lohmann, Kenneth J.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Texas A&M University System; Texas A&M University College Station
  摘要：Growing evidence indicates that migratory animals exploit the magnetic field of the Earth for navigation, both as a compass to determine direction and as a map to determine geographical position1. It has long been proposed that, to navigate using a magnetic map, animals must learn the magnetic coordinates of the destination2,3, yet the pivotal hypothesis that animals can learn magnetic signatures of geographical areas has, to our knowledge, yet to be tested. Here we report that an iconic navig...
• Move beyond 'publish or perish' by measuring behaviours that benefit academia AI翻译
  作者：Allen, Kelly-Ann
  作者单位：Monash University
  摘要：A standardized system to measure scientists' contributions in mentorship, collaboration and more could bring about systemic change.
• Discovery and engineering of the antibody response to a prominent skin commensal AI翻译
  作者：Bousbaine, Djenet; Bauman, Katherine D.; Chen, Y. Erin; Lalgudi, Pranav V.; Nguyen, Tam T. D.; Swenson, Joyce M.; Yu, Victor K.; Tsang, Eunice; Conlan, Sean; Li, David B.; Jbara, Amina; Zhao, Aishan; Naziripour, Arash; Veinbachs, Alessandra; Lee, Yu E.; Phung, Jennie L.; Dimas, Alex; Jain, Sunit; Meng, Xiandong; Pham, Thi Phuong Thao; Mclaughlin, Martin I.; Barkal, Layla J.; Gribonika, Inta; Van Rompay, Koen K. A.; Kong, Heidi H.; Segre, Julia A.; Belkaid, Yasmine; Barnes, Christopher O.; Fischbach, Michael A.
  作者单位：Stanford University; Stanford University; Stanford University; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of California System; University of California Davis; University of California System; University of California Davis; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
  摘要：The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of an infection1. However, the scope and purpose of this anticommensal immune programme are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable and specific antibody response that is conserved in humans and non-human primates. A series of S. epidermidis cell-wall mutants revealed that the cell surf...
• China's low-altitude economy needs to grow with more caution AI翻译
  作者：Wang, Yong; Ran, Dexin
  作者单位：Qingdao University of Technology
• Transcriptomic neuron types vary topographically in function and morphology AI翻译
  作者：Shainer, Inbal; Kappel, Johannes M.; Laurell, Eva; Donovan, Joseph C.; Schneider, Martin W.; Kuehn, Enrico; Arnold-Ammer, Irene; Stemmer, Manuel; Larsch, Johannes; Baier, Herwig
  作者单位：Technion Israel Institute of Technology; Friedrich Miescher Institute for Biomedical Research; University of Lausanne
  摘要：Neuronal phenotypic traits such as morphology, connectivity and function are dictated, to a large extent, by a specific combination of differentially expressed genes. Clusters of neurons in transcriptomic space correspond to distinct cell types and in some cases-for example, Caenorhabditis elegans neurons1 and retinal ganglion cells2, 3-4-have been shown to share morphology and function. The zebrafish optic tectum is composed of a spatial array of neurons that transforms visual inputs into mot...
• A cell atlas foundation model for scalable search of similar human cells AI翻译
  作者：Heimberg, Graham; Kuo, Tony; Depianto, Daryle J.; Salem, Omar; Heigl, Tobias; Diamant, Nathaniel; Scalia, Gabriele; Biancalani, Tommaso; Turley, Shannon J.; Rock, Jason R.; Bravo, Hector Corrada; Kaminker, Josh; Vander Heiden, Jason A.; Regev, Aviv
  作者单位：Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Roche Holding USA; Genentech
  摘要：Single-cell RNA sequencing has profiled hundreds of millions of human cells across organs, diseases, development and perturbations to date. Mining these growing atlases could reveal cell-disease associations, identify cell states in unexpected tissue contexts and relate in vivo biology to in vitro models. These require a common measure of cell similarity across the body and an efficient way to search. Here we develop SCimilarity, a metric-learning framework to learn a unified and interpretable...
• Learn COVID pandemic lessons - before it's too late AI翻译
  作者：[Anonymous]
• Does a cell's gene expression always reflect its function? AI翻译
  作者：Ozel, M. Neset; Desplan, Claude
  作者单位：Stowers Institute for Medical Research; New York University
• Synthetic lethality of mRNA quality control complexes in cancer AI翻译
  作者：Prindle, Vivian; Richardson, Adam E.; Sher, Kimberly R.; Kongpachith, Sarah; Kentala, Kaitlin; Petiwala, Sakina; Cheng, Dong; Widomski, Deborah; Le, Phuong; Torrent, Maricel; Chen, Anlu; Walker, Stephen; Palczewski, Marianne B.; Mitra, Diya; Manaves, Vlasios; Shi, Xu; Lu, Charles; Sandoval, Stephanie; Dezso, Zoltan; Buchanan, F. Gregory; Verduzco, Daniel; Bierie, Brian; Meulbroek, Jonathan A.; Pappano, William N.; Plotnik, Joshua P.
  作者单位：AbbVie
  摘要：Synthetic lethality exploits the genetic vulnerabilities of cancer cells to enable a targeted, precision approach to treat cancer1. Over the past 15 years, synthetic lethal cancer target discovery approaches have led to clinical successes of PARP inhibitors2 and ushered several next-generation therapeutic targets such as WRN3, USP14, PKMYT15, POLQ6 and PRMT57 into the clinic. Here we identify, in human cancer, a novel synthetic lethal interaction between the PELO-HBS1L and SKI complexes of the...
• Total synthesis of 25 picrotoxanes by virtual library selection AI翻译
  作者：Li, Chunyu; Shenvi, Ryan A.
  作者单位：Scripps Research Institute; Scripps Research Institute
  摘要：The synthesis of a complex molecule begins from an initial design stage1, 2, 3-4 in which possible routes are triaged by strategy and feasibility, on the basis of analogy to similar reactions2,3. However, as molecular complexity increases, predictability decreases5; inevitably, even experienced chemists resort to trial and error to identify viable intermediates en route to the target molecule. We encountered such a problem in the synthesis of picrotoxane sesquiterpenes in which pattern-recogni...