8054期

最新文章

• Exclusive: NIH to terminate hundreds of active research grants AI翻译
  作者：Kozlov, Max; Mallapaty, Smriti
• A framework for neural organoids, assembloids and transplantation studies AI翻译
  作者：Pasca, Sergiu P.; Arlotta, Paola; Bateup, Helen S.; Camp, J. Gray; Cappello, Silvia; Gage, Fred H.; Knoblich, Juergen A.; Kriegstein, Arnold R.; Lancaster, Madeline A.; Ming, Guo-Li; Novarino, Gaia; Okano, Hideyuki; Parmar, Malin; Park, In-Hyun; Reiner, Orly; Song, Hongjun; Studer, Lorenz; Takahashi, Jun; Temple, Sally; Testa, Giuseppe; Treutlein, Barbara; Vaccarino, Flora M.; Vanderhaeghen, Pierre; Young-Pearse, Tracy
  作者单位：Stanford University; Stanford University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Roche Holding; University of Basel; University of Munich; Max Planck Society; Salk Institute; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Austrian Academy of Sciences; Medical University of Vienna; University of California System; University of California San Francisco; University of California System; University of California San Francisco; MRC Laboratory Molecular Biology; University of Cambridge; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Institute of Science & Technology - Austria; Keio University; Lund University; Yale University; Yale University; Weizmann Institute of Science; Weizmann Institute of Science; University of Pennsylvania; Memorial Sloan Kettering Cancer Center; Kyoto University; University of Milan; Human Technopole; Yale University; Yale University; Flanders Institute for Biotechnology (VIB); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University
  摘要：As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human...
• Targeting protein-ligand neosurfaces with a generalizable deep learning tool AI翻译
  作者：Marchand, Anthony; Buckley, Stephen; Schneuing, Arne; Pacesa, Martin; Elia, Maddalena; Gainza, Pablo; Elizarova, Evgenia; Neeser, Rebecca M.; Lee, Pao-Wan; Reymond, Luc; Miao, Yangyang; Scheller, Leo; Georgeon, Sandrine; Schmidt, Joseph; Schwaller, Philippe; Maerkl, Sebastian J.; Bronstein, Michael; Correia, Bruno E.
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); University of Oxford; Austrian Academy of Sciences
  摘要：Molecular recognition events between proteins drive biological processes in living systems1. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules2, 3, 4-5. Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field6,7. Here we present a computational strategy for the design of proteins that target neosurfaces, that is,...
• Trump's nominee for NIH chief talks frozen grants and fostering 'scientific dissent' AI翻译
  作者：Nowogrodzki, Julian
• Metals squeezed to thickness of just two atoms AI翻译
  作者：Sanchez-Yamagishi, Javier
  作者单位：University of California System; University of California Irvine
• Emerging supersolidity in photonic-crystal polariton condensates AI翻译
  作者：Trypogeorgos, Dimitrios; Gianfrate, Antonio; Landini, Manuele; Nigro, Davide; Gerace, Dario; Carusotto, Iacopo; Riminucci, Fabrizio; Baldwin, Kirk W.; Pfeiffer, Loren N.; Martone, Giovanni I.; De Giorgi, Milena; Ballarini, Dario; Sanvitto, Daniele
  作者单位：Consiglio Nazionale delle Ricerche (CNR); Istituto di Nanotecnologia (NANOTEC-CNR); University of Innsbruck; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); University of Trento; University of Trento; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Princeton University
  摘要：A supersolid is a counter-intuitive phase of matter in which its constituent particles are arranged into a crystalline structure, yet they are free to flow without friction. This requires the particles to share a global macroscopic phase while being able to reduce their total energy by spontaneous, spatial self-organization. The existence of the supersolid phase of matter was speculated more than 50 years ago1, 2, 3-4. However, only recently has there been convincing experimental evidence, mai...
• Global biodiversity loss from outsourced deforestation AI翻译
  作者：Wiebe, R. Alex; Wilcove, David S.
  作者单位：Princeton University; Princeton University; Princeton University
  摘要：Globalization increasingly allows countries to externalize the environmental costs of land use, including biodiversity loss1. So far, we have a very incomplete understanding of how countries cause biodiversity loss outside their own borders through their demand for agricultural and forestry products grown in other countries2. Here we quantify the global range losses to forest vertebrates from 2001 to 2015 caused by deforestation attributable to 24 developed countries by means of their consumpt...
• Multi-interface licensing of protein import into a phage nucleus AI翻译
  作者：Kokontis, Claire; Klein, Timothy A.; Silas, Sukrit; Bondy-Denomy, Joseph
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Bacteriophages use diverse mechanisms to evade antiphage defence systems. Phi KZ-like jumbo phages assemble a proteinaceous, nucleus-like compartment that excludes antagonistic host nucleases and also internalizes DNA replication and transcription machinery1, 2, 3-4. The phage factors required for protein import and the mechanisms of selectivity remain unknown, however. Here we uncover an import system comprising proteins highly conserved across nucleus-forming phages, together with additional...
• 'Omg, did PubMed go dark?' Blackout stokes fears about database's future AI翻译
  作者：Mallapaty, Smriti
• Greenland genetic data can narrow health-care gaps AI翻译
  作者：Arbour, Laura
  作者单位：University of British Columbia
  摘要：A study involving 14% of the people in Greenland makes a case for including under-represented groups in population genomics data - which could reduce inequalities in genetics-based clinical care and personalized medicine.